ES8104403A1 - Procedimiento para purificar polisacaridos capsulares neumo-coccicos - Google Patents

Procedimiento para purificar polisacaridos capsulares neumo-coccicos

Info

Publication number
ES8104403A1
ES8104403A1 ES493128A ES493128A ES8104403A1 ES 8104403 A1 ES8104403 A1 ES 8104403A1 ES 493128 A ES493128 A ES 493128A ES 493128 A ES493128 A ES 493128A ES 8104403 A1 ES8104403 A1 ES 8104403A1
Authority
ES
Spain
Prior art keywords
pneumococcal
pneumococcal vaccine
multivalent pneumococcal
types
multivalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493128A
Other languages
English (en)
Other versions
ES493128A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES8104403A1 publication Critical patent/ES8104403A1/es
Publication of ES493128A0 publication Critical patent/ES493128A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PURIFICAR POLISACARIDOS CAPSULARES NEUMOCOCCICOS DE LOS TIPOS, 1, 2, 3, 4, 6A, 6B, 7F, 8, 9N, 12F, 14, 18C, 19F, 20, 23F Y 25, ADECUADOS PARA PREPARAR VACUNAS MULTIVALENTES. EL PROCEDIMIENTO DE PURIFICACION CONSISTE EN LA SEPARACION DEL POLISACARIDO NEUMOCOCCICO, A PARTIR DE UN LISATO DE FERMENTACION CLARIFICADO, A TRAVES DE UNA SERIE DE ETAPAS DE PRECIPITACION, REDISOLUCION, EXTRACCION Y TATAMIENTO CON CARBON ACTIVO, QUE VARIAN DEPENDIENDO DEL TIPO DE LISATO Y DEL POLISACARIDO A SEPARAR. LA DISOLUCION RESULTANTE DE SEPARAR EL CARBON ACTIVO POR FILTRACION SE DIAFILTRA Y EL PRODUCTO RESULTANTE SE CONGELA Y LIOFILIZA.
ES493128A 1979-08-08 1980-07-04 Procedimiento para purificar polisacaridos capsulares neumo-coccicos Granted ES493128A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/064,663 US4242501A (en) 1979-08-08 1979-08-08 Purification of pneumococcal capsular polysaccharides

Publications (2)

Publication Number Publication Date
ES8104403A1 true ES8104403A1 (es) 1981-04-01
ES493128A0 ES493128A0 (es) 1981-04-01

Family

ID=22057464

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493128A Granted ES493128A0 (es) 1979-08-08 1980-07-04 Procedimiento para purificar polisacaridos capsulares neumo-coccicos

Country Status (8)

Country Link
US (1) US4242501A (es)
EP (1) EP0024493B1 (es)
JP (1) JPS5629524A (es)
AR (1) AR228430A1 (es)
AU (1) AU534274B2 (es)
CA (1) CA1146862A (es)
DE (1) DE3070753D1 (es)
ES (1) ES493128A0 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324887A (en) * 1978-08-16 1982-04-13 President And Fellows Of Harvard College Type II group B Streptococci polysaccharide
US4367221A (en) * 1980-06-09 1983-01-04 President And Fellows Of Harvard College Immunization against Group B streptococci
US4367222A (en) * 1980-06-09 1983-01-04 President And Fellows Of Harvard College Immune globulin specific to Group B streptococci
US4367223A (en) * 1980-06-09 1983-01-04 President And Fellows Of Harvard College Vaccine against Group B streptococci
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
US5370871A (en) * 1983-01-24 1994-12-06 The Johns Hopkins University Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry
US4686102A (en) * 1984-04-12 1987-08-11 American Cyanamid Company Multivalent pneumococcal vaccine and preparation thereof
US4894332A (en) * 1985-03-27 1990-01-16 Biogen, Inc. DNA sequences coding for Mycoplasma hypopneumoniae surface antigens, methods of use to make the corresponding proteins
JPH05506984A (ja) * 1990-04-02 1993-10-14 サイナーゲン，インコーポレーテッド 動物におけるマイコプラズマ感染に対する診断と治療に有用なポリペプチド
CA2059692C (en) * 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
US5565204A (en) * 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
US5714354A (en) * 1995-06-06 1998-02-03 American Home Products Corporation Alcohol-free pneumococcal polysaccharide purification process
US6410025B1 (en) 1996-02-14 2002-06-25 Merck & Co., Inc. Polysaccharide precipitation process
US5989542A (en) * 1997-08-20 1999-11-23 Brigham And Women's Hospital, Inc. Capsular polysaccharides from enterococci
US6722062B2 (en) 1997-08-20 2004-04-20 The Brigham And Women's Hospital, Inc. Capsular polysaccharides from enterococci
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
JP3736750B2 (ja) 2001-12-21 2006-01-18 Ｙｋｋ株式会社 開離嵌挿具付きのスライドファスナーとその製造方法
JP4594298B2 (ja) * 2003-02-27 2010-12-08 グラクソ グループ リミテッド 高純度フォンダパリヌクスナトリウム組成物
DE602004025951D1 (de) * 2003-09-11 2010-04-22 Staat Der Nederlanden Vert Doo Verfahren zur herstellung eines kapselpolysaccharids zur verwendung in konjugat-impfstoffen
GB0502096D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Purification of streptococcal capsular polysaccharide
CN101155833B (zh) * 2005-04-08 2011-04-20 惠氏公司 通过pH操作将污染物与肺炎链球菌多糖分离
CN101663327B (zh) * 2007-03-23 2014-05-07 惠氏公司 产生肺炎链球菌(streptococcus pneumoniae)荚膜多糖的缩短的纯化方法
WO2008129559A2 (en) 2007-04-23 2008-10-30 Serum Institute Of India Ltd Antigenic polysaccharides and process for their preparation
ES2749952T3 (es) 2008-12-18 2020-03-24 Wyeth Llc Procedimiento de control del peso molecular de polisacáridos de Streptococcus pneumoniae usando carbono
BRPI0922981A8 (pt) 2008-12-18 2019-11-26 Wyeth Llc método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae
WO2011148382A1 (en) 2010-05-28 2011-12-01 Biological E Limited An improved process for the purification of capsular polysaccharides of haemophilus influenza - b, neisseria meningitis such as serotypes a, c, y and w-135, and other similar related capsular polysaccharides produced from both gram negative and gram positive microorganisms using aluminium phosphate with alcohol.
BR112013024322B1 (pt) 2011-03-22 2020-04-22 Serum Inst India Ltd processo para preparação de polissacarídeos
US11576958B2 (en) 2013-02-07 2023-02-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
WO2016174683A1 (en) 2015-04-28 2016-11-03 Biological E Limited Method for separation of protein and other impurities from microbial capsular polysaccharides
EP3436061A4 (en) 2016-03-31 2019-12-04 Liffey Biotech Limited Saccharide-polypeptide-conjugate compositions and methods of use thereof
US10702596B2 (en) 2017-07-05 2020-07-07 Inventprise, Llc Polysaccharide purification for vaccine production using lytic enzymes, tangential flow filtration, and multimode chromatography
JP7111799B2 (ja) 2017-07-05 2022-08-02 インベントプライズ リミテッド ライアビリティ カンパニー 溶菌酵素、接線流濾過、及びマルチモードクロマトグラフィを用いたワクチン生産のための多糖精製
WO2019070994A1 (en) 2017-10-04 2019-04-11 Liffey Biotech Limited SACCHARIDE-POLYPEPTIDE CONJUGATE COMPOSITIONS AND METHODS OF USE
CN114667157A (zh) * 2019-11-29 2022-06-24 龙沙有限公司 纯化多糖的方法
CN116942804A (zh) 2022-04-19 2023-10-27 上海瑞宙生物科技有限公司 多价肺炎球菌多糖结合疫苗的成分及其应用
CN120329458B (zh) * 2025-06-18 2026-04-03 北京智飞绿竹生物制药有限公司 肺炎球菌荚膜多糖的纯化方法及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2388563A1 (fr) * 1977-04-29 1978-11-24 Fabre Sa Pierre Vaccins acellulaires perfectionnes contenant des polysaccharides capsulaires
CA1115210A (en) * 1977-11-28 1981-12-29 Dennis J. Carlo Pneumococcal vaccine

Also Published As

Publication number Publication date
CA1146862A (en) 1983-05-24
JPS5629524A (en) 1981-03-24
AU6038580A (en) 1981-02-12
AU534274B2 (en) 1984-01-12
EP0024493B1 (en) 1985-06-12
EP0024493A2 (en) 1981-03-11
EP0024493A3 (en) 1981-10-21
ES493128A0 (es) 1981-04-01
AR228430A1 (es) 1983-03-15
US4242501A (en) 1980-12-30
DE3070753D1 (en) 1985-07-18

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