BRPI0922981A8 - método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae - Google Patents

método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae Download PDF

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Publication number
BRPI0922981A8
BRPI0922981A8 BRPI0922981A BRPI0922981A8 BR PI0922981 A8 BRPI0922981 A8 BR PI0922981A8 BR PI0922981 A BRPI0922981 A BR PI0922981A BR PI0922981 A8 BRPI0922981 A8 BR PI0922981A8
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Brazil
Prior art keywords
streptococcus pneumoniae
fermentation culture
molecular weight
weight control
addition
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English (en)
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Heather Crinean Jean
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Wyeth Llc
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Publication of BRPI0922981A2 publication Critical patent/BRPI0922981A2/pt
Publication of BRPI0922981A8 publication Critical patent/BRPI0922981A8/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

"método para o controle do peso molecular de polissacarídeo para o sorotipo 19a de streptococcus pneumoniae". a presente invenção refere-se a métodos melhorados para a produção de uma solução contendo polissacarídeos capsulares 19a de streptococcus pneumoniae isolado de alto peso molecular. em certos métodos, uma cultura de fermentação de células bacterianas de streptococcus pneumoniae que produzem polissacarídeos capsulares para o sorotipo 19a é fermentada durante menos do que 6 horas antes das células bacterianas serem submetidas à lise e os polissacarídeos capsulares são colhidos. em outros métodos, co2 é fornecido à cultura de fermentação. o fornecimento de co2 à cultura de fermentação inclui a adição de íons de bicarbonato na cultura de fermentação, a adição de íons de carbonato na cultura de fermentação, a adição de misturas de íons de bicarbonato e carbonato na cultura de fermentação, e sobreposição da cultura de fermentação com co2.
BRPI0922981-7 2008-12-18 2009-12-17 método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae BRPI0922981A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13856308P 2008-12-18 2008-12-18
PCT/US2009/068429 WO2010080486A2 (en) 2008-12-18 2009-12-17 Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight

Publications (2)

Publication Number Publication Date
BRPI0922981A2 BRPI0922981A2 (pt) 2015-08-25
BRPI0922981A8 true BRPI0922981A8 (pt) 2019-11-26

Family

ID=42266457

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0922981-7 BRPI0922981A8 (pt) 2008-12-18 2009-12-17 método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae

Country Status (18)

Country Link
US (1) US8795689B2 (pt)
EP (1) EP2379734B1 (pt)
JP (1) JP5843612B2 (pt)
KR (2) KR20110091546A (pt)
CN (1) CN102257155B (pt)
AU (1) AU2009335826B2 (pt)
BR (1) BRPI0922981A8 (pt)
CA (1) CA2743710C (pt)
DK (1) DK2379734T3 (pt)
ES (1) ES2666698T3 (pt)
HU (1) HUE037465T2 (pt)
IL (1) IL213169A (pt)
MX (1) MX2011006432A (pt)
PL (1) PL2379734T3 (pt)
PT (1) PT2379734T (pt)
RU (1) RU2511404C2 (pt)
SI (1) SI2379734T1 (pt)
WO (1) WO2010080486A2 (pt)

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ES2749952T3 (es) * 2008-12-18 2020-03-24 Wyeth Llc Procedimiento de control del peso molecular de polisacáridos de Streptococcus pneumoniae usando carbono
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MX2019007910A (es) 2016-12-30 2019-12-05 Sutrovax Inc Conjugados de polipeptido-antigeno con aminoacidos no naturales.
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
KR20240169144A (ko) 2017-01-31 2024-12-02 머크 샤프 앤드 돔 엘엘씨 다당류-단백질 접합체 제조 방법
KR20190121330A (ko) 2017-02-24 2019-10-25 머크 샤프 앤드 돔 코포레이션 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체의 면역원성의 증진
KR20240018698A (ko) 2017-06-10 2024-02-13 인벤트프라이즈 인크. 면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
US11389540B2 (en) * 2017-09-07 2022-07-19 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
WO2019050813A1 (en) 2017-09-07 2019-03-14 Merck Sharp & Dohme Corp. ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER
BR112020011414B8 (pt) 2017-12-06 2023-01-31 Merck Sharp & Dohme Composições imunogênicas multivalentes compreendendo conjugados de proteína carreadora e polissacarídeo de s. pneumoniae
EP3782642A4 (en) * 2018-04-18 2022-04-13 SK Bioscience Co., Ltd. CAPSULE POLYSACCHARIDES FROM STREPTOCOCCUS PNEUMONIAE AND CONJUGATES THEREOF
JP7397000B2 (ja) 2018-04-30 2023-12-12 メルク・シャープ・アンド・ドーム・エルエルシー 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法
US12144855B2 (en) 2018-04-30 2024-11-19 Merck Sharp & Dohme Llc Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres
US20210252125A1 (en) 2018-04-30 2021-08-19 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
EP3897705A2 (en) 2018-12-19 2021-10-27 Merck Sharp & Dohme Corp. Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
EP4192499A4 (en) 2020-08-10 2024-09-25 Inventprise, Inc. Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f

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Also Published As

Publication number Publication date
JP2012512660A (ja) 2012-06-07
WO2010080486A3 (en) 2010-11-04
WO2010080486A2 (en) 2010-07-15
KR20110091546A (ko) 2011-08-11
KR101593770B1 (ko) 2016-02-15
AU2009335826B2 (en) 2013-10-31
US8795689B2 (en) 2014-08-05
CA2743710A1 (en) 2010-07-15
HK1163750A1 (zh) 2012-09-14
SI2379734T1 (en) 2018-05-31
PL2379734T3 (pl) 2018-08-31
CA2743710C (en) 2017-01-24
RU2011128564A (ru) 2013-01-27
BRPI0922981A2 (pt) 2015-08-25
AU2009335826A1 (en) 2010-07-15
RU2511404C2 (ru) 2014-04-10
CN102257155A (zh) 2011-11-23
KR20130136011A (ko) 2013-12-11
ES2666698T3 (es) 2018-05-07
JP5843612B2 (ja) 2016-01-13
EP2379734A2 (en) 2011-10-26
PT2379734T (pt) 2018-04-27
HUE037465T2 (hu) 2018-09-28
IL213169A (en) 2015-02-26
CN102257155B (zh) 2016-03-02
MX2011006432A (es) 2011-09-29
DK2379734T3 (en) 2018-04-23
EP2379734B1 (en) 2018-03-21
IL213169A0 (en) 2011-07-31
US20100158953A1 (en) 2010-06-24

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B25G Requested change of headquarter approved

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