ES8105338A1 - Procedimiento para preparar derivados de di fosfonatos. - Google Patents

Procedimiento para preparar derivados de di fosfonatos.

Info

Publication number
ES8105338A1
ES8105338A1 ES488535A ES488535A ES8105338A1 ES 8105338 A1 ES8105338 A1 ES 8105338A1 ES 488535 A ES488535 A ES 488535A ES 488535 A ES488535 A ES 488535A ES 8105338 A1 ES8105338 A1 ES 8105338A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
diphosphonate
phosphate
compositions containing
phosphonate derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488535A
Other languages
English (en)
Other versions
ES488535A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symphar SA
Original Assignee
Symphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7904992A external-priority patent/GB2043073B/en
Application filed by Symphar SA filed Critical Symphar SA
Priority to ES498991A priority Critical patent/ES8201592A1/es
Publication of ES488535A0 publication Critical patent/ES488535A0/es
Publication of ES8105338A1 publication Critical patent/ES8105338A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE DIFOSFONATO. CONSISTE EN HACER REACCIONAR UN DIALQUIL-ACILFOSFONATO (I) CON UNA CANTIDAD EQUIMOLECULAR DE DIALQUILFOSFITO II EN PRESENCIA DE DIFERENTES CANTIDADES DE BASE CORRESPONDIENTE A 5 POR 100 DE LA CANTIDAD MOLAR DE CADA UNO DE LOS REACTIVOS UTILIZADOS, DICHA BASE ES UNA AMINA. LA REACCION SE EFECTUA EN DIETILETER COMO DISOLVENTE Y A UNA TEMPERATURA DE 0GC APROXIMADAMENTE. R ES CH3 O C2H5. *FORMULA*
ES488535A 1979-02-13 1980-02-13 Procedimiento para preparar derivados de di fosfonatos. Expired ES8105338A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES498991A ES8201592A1 (es) 1979-09-25 1981-01-30 Procedimiento para preparar derivados de gem-difosfonato

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7904992A GB2043073B (en) 1979-02-13 1979-02-13 Mono-and diphosphonate compounds
GB7933157A GB2043072B (en) 1979-02-13 1979-09-25 Diphosphonate compounds

Publications (2)

Publication Number Publication Date
ES488535A0 ES488535A0 (es) 1981-05-16
ES8105338A1 true ES8105338A1 (es) 1981-05-16

Family

ID=26270548

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488535A Expired ES8105338A1 (es) 1979-02-13 1980-02-13 Procedimiento para preparar derivados de di fosfonatos.

Country Status (7)

Country Link
US (2) US4309364A (es)
EP (1) EP0015370B1 (es)
AU (1) AU536326B2 (es)
CA (1) CA1148561A (es)
DE (1) DE3061551D1 (es)
ES (1) ES8105338A1 (es)
GB (1) GB2043072B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
DE3007764A1 (de) * 1980-02-29 1981-10-15 Boehringer Mannheim Gmbh Verfahren und reagens zur bestimmung der beta -lipoproteine
EP0084822B1 (de) 1982-01-27 1986-01-08 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
DE3365492D1 (en) * 1982-01-27 1986-10-02 Schering Ag Diphosphonic acid derivatives and pharmaceutical preparations containing them
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
IT1170214B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per la cura delle arteriopatie periferiche
IT1195993B (it) * 1984-01-12 1988-11-03 Gentili Ist Spa Forme farmaceutiche a base di difosfonati
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
HU190579B (en) * 1984-07-18 1986-09-29 Nitrokemia Ipartelepek,Hu Plant growth regulating compositions comprising etherified hydroxy-alkyl-phosphonic acid-derivatives as active substance
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
ATE60711T1 (de) * 1986-12-20 1991-02-15 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
US4822780A (en) * 1987-07-08 1989-04-18 Otsuka Pharmaceutical Factory, Inc. Carboxamide compounds
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (es) * 1988-03-31 1990-09-28 Symphar Sa
FI89364C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
CA2067974A1 (en) * 1991-05-13 1992-11-14 Scott A. Biller Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
CA2102303A1 (en) * 1991-06-19 1992-12-20 Roy Allen Johnson Dialkyl (dialkoxyphosphinyl) methyl phosphates as anti-inflammatory agents
US5213154A (en) * 1992-08-17 1993-05-25 Gas Research Institute Liquid desiccant regeneration system
HUT72307A (en) 1993-03-08 1996-04-29 Eisai Co Ltd Phosphonic acid derivatives
US20020128301A1 (en) * 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
FR2827289B1 (fr) * 2001-07-16 2004-07-23 Univ Paris 13 Nouveau derive d'acide diphosphonique, son application en therapeutique et procede de preparation
AU2003211109A1 (en) * 2002-02-19 2003-09-09 Ilex Products, Inc. Phosphonate-phosphate and diphosphonate apolipoprotein e modulators
AU2003228990A1 (en) * 2002-05-11 2003-11-11 Ilex Products, Inc. Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators
EP2493905B1 (en) * 2009-10-26 2016-11-30 Warner Chilcott Company, LLC Bisphosphonate compounds for treating bone metabolism disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2848475A (en) * 1953-04-20 1958-08-19 Ciba Ltd Substituted methylene bis
FR1394386A (fr) * 1963-04-09 1965-04-02 Monsanto Co Nouveaux acides organo-méthylène diphosphoniques, leurs sels et esters
DE1302557B (es) * 1963-04-09 1971-08-26
US3471406A (en) * 1965-09-07 1969-10-07 Plains Chem Dev Co Detergent compositions containing methane tri and tetra phosphonic acid compounds
US3463835A (en) * 1965-10-05 1969-08-26 Plains Chem Dev Co Aromatic polyphosphonic acids,salts and esters
FR8441M (es) * 1968-04-01 1971-07-15
GB1508772A (en) * 1975-04-04 1978-04-26 Shell Int Research Biologically active compositions
US4067971A (en) * 1976-05-13 1978-01-10 The Procter & Gamble Company Therapeutic composition
US4237165A (en) * 1976-06-04 1980-12-02 Science Union Et Cie Treatment of carbohydrate metabolism disorders
US4137309A (en) * 1976-10-14 1979-01-30 The Procter & Gamble Company Therapeutic treatment
US4113862A (en) * 1977-05-02 1978-09-12 The Procter & Gamble Company Carboxy phosphonate pharmaceutical composition
US4113861A (en) * 1977-05-02 1978-09-12 The Procter & Gamble Company Phosphonate pharmaceutical composition
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds

Also Published As

Publication number Publication date
EP0015370A1 (en) 1980-09-17
EP0015370B1 (en) 1983-01-12
GB2043072B (en) 1983-11-23
GB2043072A (en) 1980-10-01
AU5495180A (en) 1980-08-21
ES488535A0 (es) 1981-05-16
US4309364A (en) 1982-01-05
AU536326B2 (en) 1984-05-03
CA1148561A (en) 1983-06-21
US4371527A (en) 1983-02-01
DE3061551D1 (en) 1983-02-17

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