ES8200678A1 - Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas. - Google Patents

Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas.

Info

Publication number
ES8200678A1
ES8200678A1 ES495516A ES495516A ES8200678A1 ES 8200678 A1 ES8200678 A1 ES 8200678A1 ES 495516 A ES495516 A ES 495516A ES 495516 A ES495516 A ES 495516A ES 8200678 A1 ES8200678 A1 ES 8200678A1
Authority
ES
Spain
Prior art keywords
dibenzo
dihydro
procedure
tiazepinas
oxarepines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495516A
Other languages
English (en)
Other versions
ES495516A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8200678A1 publication Critical patent/ES8200678A1/es
Publication of ES495516A0 publication Critical patent/ES495516A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 10-(4-PIPERIDINIL)-10,11-DIHIDRO-DIBENZO (B,F) (1,4) OXACEPINAS; -TIAZEPINAS Y DIAZEPINAS DE FORMULA (I), EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADIALES Y Z ES -O-, -S- O -NR-, SIENDO R UNO DE VARIOS TIPOS DE RADIALES. CONSISTE EN LA REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1, R2, R3 Y Z TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), POR CUALQUIER METODO CONVENCIONAL, CON UN AGENTE REDUCTOR ADECUADO, EN UN DISOLVENTE INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE REFLUJO DE LA DISOLUCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES NEUROLEPTICA, ANTIDEPRESIVA E INDUCTORA DEL SUEÑO.
ES495516A 1979-10-01 1980-09-30 Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas. Granted ES495516A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH883679 1979-10-01
CH1132279 1979-12-20
CH26880 1980-01-14

Publications (2)

Publication Number Publication Date
ES8200678A1 true ES8200678A1 (es) 1981-11-16
ES495516A0 ES495516A0 (es) 1981-11-16

Family

ID=27171952

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495516A Granted ES495516A0 (es) 1979-10-01 1980-09-30 Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas.

Country Status (12)

Country Link
US (1) US4360525A (es)
EP (1) EP0026469B1 (es)
CA (1) CA1173829A (es)
DE (1) DE3069716D1 (es)
DK (1) DK414180A (es)
ES (1) ES495516A0 (es)
FI (1) FI803030A7 (es)
IE (1) IE50249B1 (es)
IL (1) IL61161A (es)
NZ (1) NZ195079A (es)
PH (1) PH16253A (es)
PT (1) PT71850B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH646696A5 (de) 1980-11-28 1984-12-14 Sandoz Ag Dibenzazepine, ihre herstellung und verwendung.
EP0343307A1 (en) * 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinealkanamine derivatives
US5312819A (en) * 1990-08-20 1994-05-17 Sandoz Ltd. Pharmaceutical compositions comprising clozapine and a radical scavenger
US5354747A (en) * 1993-06-16 1994-10-11 G. D. Searle & Co. 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5461047A (en) 1993-06-16 1995-10-24 G. D. Searle & Co. 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5420270A (en) * 1993-10-07 1995-05-30 G. D. Searle & Co. Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5488046A (en) * 1993-11-03 1996-01-30 G. D. Searle & Co. Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US6063779A (en) * 1997-05-15 2000-05-16 Meiji Seika Kaisha, Ltd. 5-(4-piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents
EP1569905A2 (en) * 2002-12-06 2005-09-07 Eli Lilly And Company Inhibitors of monoamine uptake

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL120551C (es) * 1959-09-22
IN108354B (es) * 1966-12-08 1975-08-16 Ciba Geigy
CA918659A (en) * 1969-07-31 1973-01-09 Yoshitomi Pharmaceutical Industries 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
US3676432A (en) * 1970-08-31 1972-07-11 Robins Co Inc A H 11,12-DIHYDRODIBENZ{8 b,f{9 AZOCIN-6(5H)-ONES
US3660406A (en) * 1970-10-26 1972-05-02 American Cyanamid Co 2-chloro-7-hydroxy-11-(1-piperazinyl)dibenz(b f)(1 4)oxazepines

Also Published As

Publication number Publication date
IL61161A (en) 1984-03-30
IE50249B1 (en) 1986-03-05
PH16253A (en) 1983-08-16
PT71850A (en) 1980-10-01
CA1173829A (en) 1984-09-04
EP0026469B1 (en) 1984-11-28
IL61161A0 (en) 1980-11-30
PT71850B (en) 1981-10-22
US4360525A (en) 1982-11-23
FI803030A7 (fi) 1981-01-01
IE802033L (en) 1981-04-01
DK414180A (da) 1981-04-02
EP0026469A1 (en) 1981-04-08
ES495516A0 (es) 1981-11-16
DE3069716D1 (en) 1985-01-10
NZ195079A (en) 1984-07-06

Similar Documents

Publication Publication Date Title
ES8402306A1 (es) Un procedimiento para la preparacion de nuevos derivados de oxabicicloalcano.
ES8304095A1 (es) Un procedimiento para la preparacion de derivados de quinazolina.
ES8303383A1 (es) Un procedimiento para la preparacion de derivados del 1,2,5-tiadiazol
ES8105001A1 (es) Procedimiento para la preparacion de nuevos bencimidazoles, sustituidos en posicion 5 o 6 con un anillo de piridazinona
ES8601170A1 (es) Procedimiento para la preparacion de nuevos derivados tiazolidinicos
ES8607924A1 (es) Un metodo de producir un derivado de 1-sulfo-2-oxoazetidina
ES8401031A1 (es) Una tetrahidroftalimida.
ES8507521A1 (es) Un procedimiento para preparar derivados de oxadiazol
ES8200389A1 (es) Procedimiento para preparar una composicion pigmentaria organica o unorganica conteniendo resina de metacrilato.
ES8706608A1 (es) Un procedimiento para preparar derivados de arilciclobutilalquilamina
ES8202855A1 (es) Procedimiento para preparar colorantes heterociclicos
ES8706654A1 (es) Un procedimiento para la preparacion de nuevos derivados de benzotiazina
ES8705453A1 (es) Un procedimiento para la preparacion de derivados de cefalosporina.
ES8604847A1 (es) Procedimiento para la preparacion de bencileteres sustitui- dos
ES8300677A1 (es) Un procedimiento para preparar compuestos de aminoetanol
ES8301883A1 (es) Procedimiento para la preparacion de derivados de ciclohexe-no
ES8405000A1 (es) Un procedimiento para la preparacion de un derivado de carbostirilo.
ES8304145A1 (es) "procedimiento para la preparacion de nuevas amidas de acidos carboxilicos".
ES8604604A1 (es) Un procedimiento para la produccion de 3,3",4"-tri-o-acilespiramicina i"-.
ES8308330A1 (es) "procedimiento para la preparacion de compuestos heterociclicos".
ES8606321A1 (es) Un procedimiento para preparar un derivado de 2-hidroxi-3- (4-fenilpiperazimil)propoxi-benzofurano
Kanda et al. Formation of a long-lived intramolecular radical ion pair from the singlet excited state of porphyrin-methylviologens combined with flexible chains
ES8601211A1 (es) Procedimiento para la preparacion de nuevos derivados de sinergistinas
ES8601089A1 (es) Procedimiento para la preparacion de compuestos antipsoria- ticos naftalenicos
ES8404851A1 (es) Un procedimiento para la preparacion de un derivado de piridoindol.