ES8308330A1 - "procedimiento para la preparacion de compuestos heterociclicos". - Google Patents
"procedimiento para la preparacion de compuestos heterociclicos".Info
- Publication number
- ES8308330A1 ES8308330A1 ES515413A ES515413A ES8308330A1 ES 8308330 A1 ES8308330 A1 ES 8308330A1 ES 515413 A ES515413 A ES 515413A ES 515413 A ES515413 A ES 515413A ES 8308330 A1 ES8308330 A1 ES 8308330A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compounds
- preparation
- heterocyclic compounds
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003326 anti-histaminergic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical group [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Lubricants (AREA)
- Gyroscopes (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS HETEROCICLICOS Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE X ES OXIGENO, AZUFRE O METILENO; LA LINEA DE TRAZOS INDICA ENLACE DOBLE O SENCILLO; Y R<1, R<2, R<3, R<4, R<5 Y R<6 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN EL CIERRE DE ANILLO MEDIANTE REACCION INTRAMOLECULAR DE UNA DIAMINA DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN HALOGENURO DE CIANOGENO; SEGUIDA DE LA EVENTUAL REACCION CON UN COMPUESTO DE FORMULA R<5-X, EN LA QUE X ES HALOGENO O SULFONILOXILO Y R<5 ES EL MISMO QUE EN LA FORMULA (I), EN UN DISOLVENTE POLAR Y EN PRESENCIA DE UNA BASE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO ANTIALERGICO, ANTIHISTAMINERGICO Y ANTISEROTOMINERGICO Y POR INHIBIR LA AGREGACION DE LAS PLAQUETAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813134672 DE3134672A1 (de) | 1981-09-02 | 1981-09-02 | Heterocyclische verbindungen, ihre herstellung und verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8308330A1 true ES8308330A1 (es) | 1983-08-16 |
| ES515413A0 ES515413A0 (es) | 1983-08-16 |
Family
ID=6140652
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515413A Granted ES515413A0 (es) | 1981-09-02 | 1982-09-01 | "procedimiento para la preparacion de compuestos heterociclicos". |
| ES521604A Expired ES8405017A1 (es) | 1981-09-02 | 1983-04-19 | Procedimiento para la preparacion de compuestos heterociclicos. |
| ES521605A Expired ES8405018A1 (es) | 1981-09-02 | 1983-04-19 | Procedimiento para la preparacion de compuestos heterociclicos. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES521604A Expired ES8405017A1 (es) | 1981-09-02 | 1983-04-19 | Procedimiento para la preparacion de compuestos heterociclicos. |
| ES521605A Expired ES8405018A1 (es) | 1981-09-02 | 1983-04-19 | Procedimiento para la preparacion de compuestos heterociclicos. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4503060A (es) |
| EP (1) | EP0073506B1 (es) |
| JP (1) | JPS5846089A (es) |
| KR (1) | KR880001988B1 (es) |
| AT (1) | ATE18049T1 (es) |
| AU (1) | AU550340B2 (es) |
| CA (1) | CA1169858A (es) |
| CS (1) | CS236680B2 (es) |
| DD (1) | DD204255A5 (es) |
| DE (2) | DE3134672A1 (es) |
| DK (1) | DK160047C (es) |
| ES (3) | ES515413A0 (es) |
| FI (1) | FI76089C (es) |
| GB (1) | GB2108112B (es) |
| GR (1) | GR77274B (es) |
| HU (1) | HU185110B (es) |
| IE (1) | IE54261B1 (es) |
| IL (1) | IL66694A0 (es) |
| NO (1) | NO160445C (es) |
| NZ (1) | NZ201780A (es) |
| PH (1) | PH19377A (es) |
| PL (1) | PL135812B1 (es) |
| PT (1) | PT75494B (es) |
| SU (1) | SU1155158A3 (es) |
| YU (1) | YU43089B (es) |
| ZA (1) | ZA826380B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60500176A (ja) * | 1982-12-30 | 1985-02-07 | ビ−チヤム グル−プ ピ−エルシ− | 四環式化合物 |
| US20020091850A1 (en) | 1992-10-23 | 2002-07-11 | Cybex Corporation | System and method for remote monitoring and operation of personal computers |
| DK0730581T3 (da) * | 1993-11-22 | 2001-11-26 | Merck & Co Inc | 3-acylaminobezazepiner |
| US5658901A (en) * | 1994-08-18 | 1997-08-19 | Merck & Co., Inc. | 2,3-dihydro-1-(2,2,2,-trifluoroethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepines |
| US5478934A (en) * | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
| US5691331A (en) * | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
| US5631251A (en) * | 1995-06-07 | 1997-05-20 | Merck & Co., Inc. | 5-cyclopropyl-1,4 benzodiazepine-2-ones |
| ATE235472T1 (de) * | 1995-06-07 | 2003-04-15 | Merck & Co Inc | N-(2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepi - 3-yl)-3-amide |
| US5700797A (en) * | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
| US5726171A (en) * | 1995-06-07 | 1998-03-10 | Merck & Co Inc | N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides |
| SG170044A1 (en) * | 2006-03-31 | 2011-04-29 | Vistakon Pharmaceuticals Llc | Ocular allergy treatments |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789410A (fr) * | 1971-10-05 | 1973-01-15 | Akzo Nv | Nieuwe imidazolidine derivaten |
| NL7202963A (es) * | 1972-03-07 | 1973-09-11 | ||
| NL7414038A (nl) * | 1974-10-28 | 1976-05-03 | Akzo Nv | Nieuwe tetracyclische pyrrolidino derivaten. |
| DE3008944A1 (de) * | 1980-03-08 | 1981-09-24 | C.H. Boehringer Sohn, 6507 Ingelheim | Dibenzimidazoazepine, ihre herstellung und verwendung |
-
1981
- 1981-09-02 DE DE19813134672 patent/DE3134672A1/de not_active Withdrawn
-
1982
- 1982-08-20 US US06/410,006 patent/US4503060A/en not_active Expired - Fee Related
- 1982-08-23 PH PH27765A patent/PH19377A/en unknown
- 1982-08-27 JP JP57149040A patent/JPS5846089A/ja active Granted
- 1982-08-28 DE DE8282107929T patent/DE3269187D1/de not_active Expired
- 1982-08-28 EP EP82107929A patent/EP0073506B1/de not_active Expired
- 1982-08-28 AT AT82107929T patent/ATE18049T1/de not_active IP Right Cessation
- 1982-08-30 CA CA000410412A patent/CA1169858A/en not_active Expired
- 1982-08-30 DD DD82242882A patent/DD204255A5/de unknown
- 1982-08-31 PL PL1982238090A patent/PL135812B1/pl unknown
- 1982-08-31 FI FI823001A patent/FI76089C/fi not_active IP Right Cessation
- 1982-08-31 GR GR69167A patent/GR77274B/el unknown
- 1982-08-31 SU SU823484887A patent/SU1155158A3/ru active
- 1982-08-31 YU YU1960/82A patent/YU43089B/xx unknown
- 1982-09-01 IE IE2131/82A patent/IE54261B1/en not_active IP Right Cessation
- 1982-09-01 ES ES515413A patent/ES515413A0/es active Granted
- 1982-09-01 AU AU87926/82A patent/AU550340B2/en not_active Ceased
- 1982-09-01 HU HU822808A patent/HU185110B/hu not_active IP Right Cessation
- 1982-09-01 DK DK391182A patent/DK160047C/da not_active IP Right Cessation
- 1982-09-01 IL IL66694A patent/IL66694A0/xx not_active IP Right Cessation
- 1982-09-01 NZ NZ201780A patent/NZ201780A/en unknown
- 1982-09-01 CS CS826355A patent/CS236680B2/cs unknown
- 1982-09-01 PT PT75494A patent/PT75494B/pt not_active IP Right Cessation
- 1982-09-01 NO NO822948A patent/NO160445C/no unknown
- 1982-09-01 ZA ZA826380A patent/ZA826380B/xx unknown
- 1982-09-01 GB GB08224915A patent/GB2108112B/en not_active Expired
- 1982-09-02 KR KR8203956A patent/KR880001988B1/ko not_active Expired
-
1983
- 1983-04-19 ES ES521604A patent/ES8405017A1/es not_active Expired
- 1983-04-19 ES ES521605A patent/ES8405018A1/es not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970203 |