ES8200875A1 - Procedimiento para preparar imidodicarbonatos de dialquilo - Google Patents
Procedimiento para preparar imidodicarbonatos de dialquiloInfo
- Publication number
- ES8200875A1 ES8200875A1 ES497806A ES497806A ES8200875A1 ES 8200875 A1 ES8200875 A1 ES 8200875A1 ES 497806 A ES497806 A ES 497806A ES 497806 A ES497806 A ES 497806A ES 8200875 A1 ES8200875 A1 ES 8200875A1
- Authority
- ES
- Spain
- Prior art keywords
- congeners
- azido
- ethoxyethyl
- pyrimidinyl
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XIVXCUPDKMCGCX-UHFFFAOYSA-N N-[4-azido-5-(2-ethoxyethyl)-6-phenylpyrimidin-2-yl]acetamide Chemical compound CCOCCC1=C(N=[N+]=[N-])N=C(NC(C)=O)N=C1C1=CC=CC=C1 XIVXCUPDKMCGCX-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000039 congener Substances 0.000 title abstract 2
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR IMIDODICARBONATOS DE DIALQUILO, DE FORMULA ESTRUCTURAL (I), DONDE AM REPRESENTA (1-OXOALQUIL)AMINO, BIS(1-OXOALQUIL)AMINO, EN DONDE CADA UNO DE LOS CONSTITUYENTES OXOALQUILOS, ALQUILOS Y ALCOXIS CONTIENEN MENOS DE CINCO ATOMOS DE CARBONO. CONSISTE EN HACER REACCIONAR COMPUESTOS 2-AMINOPIRIMIDINAS DE FORMULA ESTRUCTURAL (II), CON DICARBONATOS DE DIALQUILO, EN PRESENCIA DE PIRIDINA Y A UNA TEMPERATURA DE 25 GRADOS APROXIMADAMENTE, PARA OBTENER LOS COMPUESTOS DE FORMULA (I), LOS CUALES, OPCIONALMENTE, SE CALIENTAN CON BICARBONATO POTASICO, EN PRESENCIA DE METANOL ACUOSO, PARA PREPARAR LOS CARBOMATOS DE FORMULA (I). DE USO EN FARMACIA COMO DIURETICO O COMBINADOS CON UNO O MAS COADYUVANTES CON FINES TERAPEUTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/028,034 US4205169A (en) | 1979-04-09 | 1979-04-09 | N-[4-Azido-5-(2-ethoxyethyl)-6-phenyl-2-pyrimidinyl]acetamide and congeners |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8200875A1 true ES8200875A1 (es) | 1981-11-16 |
| ES497806A0 ES497806A0 (es) | 1981-11-16 |
Family
ID=21841194
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES490388A Expired ES8104251A1 (es) | 1979-04-09 | 1980-04-09 | Procedimiento para preparar acetamidas |
| ES497805A Expired ES8200876A1 (es) | 1979-04-09 | 1980-12-16 | Procedimiento para preparar ureas |
| ES497806A Granted ES497806A0 (es) | 1979-04-09 | 1980-12-16 | Procedimiento para preparar imidodicarbonatos de dialquilo |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES490388A Expired ES8104251A1 (es) | 1979-04-09 | 1980-04-09 | Procedimiento para preparar acetamidas |
| ES497805A Expired ES8200876A1 (es) | 1979-04-09 | 1980-12-16 | Procedimiento para preparar ureas |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4205169A (es) |
| JP (1) | JPS568369A (es) |
| AU (1) | AU5722180A (es) |
| BE (1) | BE882680A (es) |
| CA (1) | CA1130287A (es) |
| DE (1) | DE3013504A1 (es) |
| DK (1) | DK150180A (es) |
| ES (3) | ES8104251A1 (es) |
| FR (1) | FR2453857A1 (es) |
| GB (1) | GB2048860B (es) |
| IT (1) | IT1127438B (es) |
| NL (1) | NL8002061A (es) |
| SE (1) | SE8002608L (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4294830A (en) * | 1980-06-16 | 1981-10-13 | G. D. Searle & Co. | {[[4-Azido-5-(ethoxyethyl)-6-phenyl-2-pyrimidinyl]amino]carbonyl}glycine and esters thereof |
| US4483987A (en) * | 1983-06-20 | 1984-11-20 | G. D. Searle & Co. | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412094A (en) * | 1967-06-21 | 1968-11-19 | Searle & Co | 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners |
| US3455921A (en) * | 1967-09-01 | 1969-07-15 | Searle & Co | 2,4-diazido-6-phenylpyrimidines and intermediates |
-
1979
- 1979-04-09 US US06/028,034 patent/US4205169A/en not_active Expired - Lifetime
-
1980
- 1980-04-08 AU AU57221/80A patent/AU5722180A/en not_active Abandoned
- 1980-04-08 FR FR8007834A patent/FR2453857A1/fr active Pending
- 1980-04-08 DE DE19803013504 patent/DE3013504A1/de not_active Withdrawn
- 1980-04-08 NL NL8002061A patent/NL8002061A/nl not_active Application Discontinuation
- 1980-04-08 IT IT48362/80A patent/IT1127438B/it active
- 1980-04-08 SE SE8002608A patent/SE8002608L/xx not_active Application Discontinuation
- 1980-04-08 BE BE0/200145A patent/BE882680A/fr unknown
- 1980-04-08 CA CA349,342A patent/CA1130287A/en not_active Expired
- 1980-04-08 DK DK150180A patent/DK150180A/da not_active IP Right Cessation
- 1980-04-09 JP JP4670080A patent/JPS568369A/ja active Pending
- 1980-04-09 GB GB8011795A patent/GB2048860B/en not_active Expired
- 1980-04-09 ES ES490388A patent/ES8104251A1/es not_active Expired
- 1980-12-16 ES ES497805A patent/ES8200876A1/es not_active Expired
- 1980-12-16 ES ES497806A patent/ES497806A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SE8002608L (sv) | 1980-10-10 |
| JPS568369A (en) | 1981-01-28 |
| GB2048860B (en) | 1982-12-15 |
| ES490388A0 (es) | 1981-04-16 |
| IT8048362A0 (it) | 1980-04-08 |
| NL8002061A (nl) | 1980-10-13 |
| IT1127438B (it) | 1986-05-21 |
| AU5722180A (en) | 1980-10-16 |
| CA1130287A (en) | 1982-08-24 |
| GB2048860A (en) | 1980-12-17 |
| ES8104251A1 (es) | 1981-04-16 |
| DE3013504A1 (de) | 1980-11-13 |
| BE882680A (fr) | 1980-10-08 |
| ES497805A0 (es) | 1981-11-16 |
| FR2453857A1 (fr) | 1980-11-07 |
| DK150180A (da) | 1980-10-10 |
| ES8200876A1 (es) | 1981-11-16 |
| US4205169A (en) | 1980-05-27 |
| ES497806A0 (es) | 1981-11-16 |
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