ES8201579A1 - Procedimiento para la preparacion de nuevas 8-fenil-purinas - Google Patents

Procedimiento para la preparacion de nuevas 8-fenil-purinas

Info

Publication number
ES8201579A1
ES8201579A1 ES499379A ES499379A ES8201579A1 ES 8201579 A1 ES8201579 A1 ES 8201579A1 ES 499379 A ES499379 A ES 499379A ES 499379 A ES499379 A ES 499379A ES 8201579 A1 ES8201579 A1 ES 8201579A1
Authority
ES
Spain
Prior art keywords
purines
phenyl
procedure
preparation
alcoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499379A
Other languages
English (en)
Other versions
ES499379A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8201579A1 publication Critical patent/ES8201579A1/es
Publication of ES499379A0 publication Critical patent/ES499379A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE 8-FENIL-PURINAS DE FORMULA (I), EN QUE R1 ES UN GRUPO ALCOXI, ALCOHILSULFINILO O ALCOHISSULFONILO, Y R2 UN GRUPO ALCOXI. SE BASA EN LA OXIDACION DE UN COMPUESTO DE FORMULA (II), EN QUE R3 ES UN GRUPO ALCOXI, ALCOHILMERCAPTO O ALCOHILSULFINILO; CON PEROXIDO DE HIDROGENO, ACIDO TRIFLUOROACETICO U OTROS, EN UN MEDIO DISOLVENTE, A TEMPERATURA DE -80 A 100 C. SE LAVA LA SOLUCION DE REACCION CON AGUA. SE CONCENTRA POR EVAPORACION DE LA FASE ORGANICA Y SE PURIFICA EL PRODUCTO FINAL POR CROMATOGRAFIA EN GEL DE SILICE. DE APLICACION EN MEDICAMENTOS COMO AGENTES DE EFECTO INOTROPO POSITIVO.
ES499379A 1979-07-11 1981-02-12 Procedimiento para la preparacion de nuevas 8-fenil-purinas Granted ES499379A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792927988 DE2927988A1 (de) 1979-07-11 1979-07-11 Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES8201579A1 true ES8201579A1 (es) 1981-12-16
ES499379A0 ES499379A0 (es) 1981-12-16

Family

ID=6075442

Family Applications (2)

Application Number Title Priority Date Filing Date
ES492075A Granted ES492075A0 (es) 1979-07-11 1980-06-02 Procedimiento para la preparacion de nuevas 8-fenil-purinas
ES499379A Granted ES499379A0 (es) 1979-07-11 1981-02-12 Procedimiento para la preparacion de nuevas 8-fenil-purinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES492075A Granted ES492075A0 (es) 1979-07-11 1980-06-02 Procedimiento para la preparacion de nuevas 8-fenil-purinas

Country Status (18)

Country Link
US (1) US4299834A (es)
EP (1) EP0024290B1 (es)
JP (1) JPS5612389A (es)
AT (1) ATE2079T1 (es)
AU (1) AU536272B2 (es)
CA (1) CA1136133A (es)
DE (2) DE2927988A1 (es)
DK (1) DK145344C (es)
ES (2) ES492075A0 (es)
FI (1) FI67219C (es)
GR (1) GR69621B (es)
IE (1) IE50291B1 (es)
IL (1) IL60531A (es)
NO (1) NO152373C (es)
NZ (1) NZ194302A (es)
PH (1) PH16017A (es)
PT (1) PT71532B (es)
ZA (1) ZA804145B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904785A (en) * 1982-05-03 1990-02-27 Eli Lilly And Company 2-phenylimidazo[4,5-c]pyridines
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4537889A (en) * 1982-12-27 1985-08-27 Eli Lilly And Company Inotropic agents
US4636502A (en) * 1982-12-27 1987-01-13 Eli Lilly And Company Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
DE3346640A1 (de) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, deren herstellung und diese verbindungen enthaltende arzneimittel
US4670445A (en) * 1984-03-05 1987-06-02 Eli Lilly And Company Inotropic agents
US4578387A (en) * 1984-03-05 1986-03-25 Eli Lilly And Company Inotropic agents
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4740599A (en) * 1986-10-03 1988-04-26 Eli Lilly And Company Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines
JPH01241353A (ja) * 1988-03-18 1989-09-26 Tokai Rika Co Ltd 金属塊の鋳造装置
US5498620A (en) * 1989-05-19 1996-03-12 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor 1,2,3-triazolo compounds
US5880129A (en) * 1989-05-19 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting invasion and metastasis of malignant solid tumors
US5359078A (en) * 1989-05-19 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor compounds
JP2002506462A (ja) 1997-06-26 2002-02-26 イーライ・リリー・アンド・カンパニー 抗血栓物質
US20080058424A1 (en) * 2002-05-23 2008-03-06 Cephalon, Inc. Novel pharmaceutical formulations of modafinil
ES2309213T3 (es) * 2001-11-16 2008-12-16 Nippon Chemiphar Co., Ltd. Inhibidor de xantina-oxidasa.
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
CN101248074A (zh) * 2005-07-01 2008-08-20 日本化学医药株式会社 黄嘌呤氧化酶抑制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813394A (en) * 1969-08-18 1974-05-28 Fujisawa Pharmaceutical Co Purine derivatives having hypocholesterolemic activity

Also Published As

Publication number Publication date
ATE2079T1 (de) 1983-01-15
EP0024290A1 (de) 1981-03-04
PT71532B (de) 1981-12-14
AU6031180A (en) 1981-01-15
IE50291B1 (en) 1986-03-19
IL60531A (en) 1983-05-15
EP0024290B1 (de) 1982-12-22
NO152373B (no) 1985-06-10
DK179880A (da) 1981-01-12
DE3061424D1 (en) 1983-01-27
IE801436L (en) 1981-01-11
NZ194302A (en) 1983-04-12
US4299834A (en) 1981-11-10
IL60531A0 (en) 1980-09-16
DK145344B (da) 1982-11-01
FI802204A7 (fi) 1981-01-12
PT71532A (de) 1980-08-01
ES8201161A1 (es) 1981-11-01
DE2927988A1 (de) 1981-02-05
CA1136133A (en) 1982-11-23
GR69621B (es) 1982-07-06
PH16017A (en) 1983-05-30
NO152373C (no) 1985-09-18
AU536272B2 (en) 1984-05-03
ES499379A0 (es) 1981-12-16
ZA804145B (en) 1982-03-31
NO802068L (no) 1981-01-12
FI67219C (fi) 1985-02-11
ES492075A0 (es) 1981-11-01
FI67219B (fi) 1984-10-31
DK145344C (da) 1983-05-02
JPS5612389A (en) 1981-02-06

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