ES8201969A1 - Procedimiento para preparar nuevos derivados de (1-(2-mer- captocicloalcohil)carbonil)-l-prolina - Google Patents
Procedimiento para preparar nuevos derivados de (1-(2-mer- captocicloalcohil)carbonil)-l-prolinaInfo
- Publication number
- ES8201969A1 ES8201969A1 ES500158A ES500158A ES8201969A1 ES 8201969 A1 ES8201969 A1 ES 8201969A1 ES 500158 A ES500158 A ES 500158A ES 500158 A ES500158 A ES 500158A ES 8201969 A1 ES8201969 A1 ES 8201969A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- proline
- acylthiocycloalkyl
- carbonyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/20—Unsaturated compounds having a carboxyl group bound to a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE (1-(2-MERCAPTOCICLOALCOHIL) CARBONIL)-L-PROLINA, DE FORMULA (I), EN LA QUE R, R1, R2 Y R'' PUEDEN SER HIDROGENO O RADICAL ALCOHILO C1-4, Y N VALE DE 1 A 5. CONSISTE EN LA REACCION DE CONDENSACION DE UN ACIDO 2-ACILTIOCICLOALCOHIL CARBOXILICO, DE FORMULA (II) EN LA QUE R, R1, R'' Y N TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y R'''' ES METILO O FENILO, CON UN SUSTRATO DE L-PROLINA, SEGUIDA DE LA SEPARACION DEL GRUPO PROTECTOR R''''-C = O; TODO ELLO SIGUIENDO PROCEDIMIENTOS CONVENCIONALES. SE PUEDE HACER REACCIONAR DIRECTAMENTE EL ACIDO DE FORMULA (II) EN EL CLORURO DE ACIDO CORRESPONDIENTE, QUE REACCIONA CON LA SAL SODICA DE LA L-PROLINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8007756 | 1980-03-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8201969A1 true ES8201969A1 (es) | 1982-01-01 |
| ES500158A0 ES500158A0 (es) | 1982-01-01 |
Family
ID=10511933
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500158A Granted ES500158A0 (es) | 1980-03-07 | 1981-03-06 | Procedimiento para preparar nuevos derivados de (1-(2-mer- captocicloalcohil)carbonil)-l-prolina |
| ES502338A Expired ES8204718A1 (es) | 1980-03-07 | 1981-05-20 | Un procedimiento para preparar derivados de prolina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES502338A Expired ES8204718A1 (es) | 1980-03-07 | 1981-05-20 | Un procedimiento para preparar derivados de prolina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4496743A (es) |
| JP (1) | JPS56139456A (es) |
| AR (1) | AR231126A1 (es) |
| AT (1) | AT375641B (es) |
| AU (1) | AU542211B2 (es) |
| BE (1) | BE887825A (es) |
| CA (1) | CA1144172A (es) |
| CH (1) | CH649531A5 (es) |
| DE (1) | DE3108543A1 (es) |
| DK (1) | DK102381A (es) |
| ES (2) | ES500158A0 (es) |
| FI (1) | FI810615L (es) |
| FR (1) | FR2477539A1 (es) |
| GR (1) | GR74121B (es) |
| IE (1) | IE50989B1 (es) |
| IL (1) | IL62194A (es) |
| IT (1) | IT1169217B (es) |
| LU (1) | LU83186A1 (es) |
| MA (1) | MA19086A1 (es) |
| NL (1) | NL8101086A (es) |
| NO (1) | NO155007C (es) |
| PH (1) | PH15896A (es) |
| PT (1) | PT72633B (es) |
| SE (1) | SE447104B (es) |
| YU (1) | YU58781A (es) |
| ZA (1) | ZA811069B (es) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| FR2394529A2 (fr) * | 1977-06-13 | 1979-01-12 | Synthelabo | Methoxy-2 benzamides et leur application en therapeutique |
| US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| US4091024A (en) * | 1976-12-03 | 1978-05-23 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
| US4123544A (en) * | 1977-03-02 | 1978-10-31 | Merrell Toraude S. A. | Acetylsalicylic acid derivatives |
| US4108886A (en) * | 1977-03-11 | 1978-08-22 | E. R. Squibb & Sons, Inc. | Thiopropanoylamino acid derivatives |
| PH15381A (en) * | 1978-02-21 | 1982-12-17 | Squibb & Sons Inc | Halogen substituted mercaptoacylamino acids |
| JPS54138551A (en) * | 1978-04-14 | 1979-10-27 | Sumitomo Chem Co Ltd | Novel asymmetric synthesis of optically active 2-alkanoyl- 1,2,3,4-tetrahydro-2-naphthol compound |
| CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
| US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
| US4385062A (en) * | 1980-01-09 | 1983-05-24 | Gruppo Lepetit S.P.A. | 1-[(-2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents |
| GB2072165B (en) * | 1980-03-07 | 1983-11-23 | Lepetit Spa | 1-(2-mercaptocycloalkyl)carbonyl-l-proline derivatives the process for their manufacture the intermediates for their synthesis and their use as antihypertensive agents |
-
1981
- 1981-02-17 AU AU67366/81A patent/AU542211B2/en not_active Ceased
- 1981-02-18 ZA ZA00811069A patent/ZA811069B/xx unknown
- 1981-02-20 GR GR64199A patent/GR74121B/el unknown
- 1981-02-23 IL IL62194A patent/IL62194A/xx unknown
- 1981-02-25 IT IT19960/81A patent/IT1169217B/it active
- 1981-02-27 FI FI810615A patent/FI810615L/fi not_active Application Discontinuation
- 1981-03-02 PH PH25288A patent/PH15896A/en unknown
- 1981-03-03 CH CH1418/81A patent/CH649531A5/fr not_active IP Right Cessation
- 1981-03-04 MA MA19290A patent/MA19086A1/fr unknown
- 1981-03-04 NO NO810748A patent/NO155007C/no unknown
- 1981-03-04 JP JP2999181A patent/JPS56139456A/ja active Granted
- 1981-03-05 IE IE483/81A patent/IE50989B1/en unknown
- 1981-03-05 LU LU83186A patent/LU83186A1/fr unknown
- 1981-03-06 ES ES500158A patent/ES500158A0/es active Granted
- 1981-03-06 PT PT72633A patent/PT72633B/pt unknown
- 1981-03-06 BE BE0/204033A patent/BE887825A/fr not_active IP Right Cessation
- 1981-03-06 AT AT0104981A patent/AT375641B/de not_active IP Right Cessation
- 1981-03-06 YU YU00587/81A patent/YU58781A/xx unknown
- 1981-03-06 SE SE8101447A patent/SE447104B/sv not_active IP Right Cessation
- 1981-03-06 AR AR284543A patent/AR231126A1/es active
- 1981-03-06 FR FR8104558A patent/FR2477539A1/fr active Granted
- 1981-03-06 NL NL8101086A patent/NL8101086A/nl not_active Application Discontinuation
- 1981-03-06 DE DE19813108543 patent/DE3108543A1/de not_active Ceased
- 1981-03-06 CA CA000372483A patent/CA1144172A/en not_active Expired
- 1981-03-06 DK DK102381A patent/DK102381A/da not_active Application Discontinuation
- 1981-05-20 ES ES502338A patent/ES8204718A1/es not_active Expired
-
1983
- 1983-01-26 US US06/460,972 patent/US4496743A/en not_active Expired - Fee Related
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