ES8202000A1 - PROCEDURE FOR PREPARING PIRIMIDIL-QUINAZOLINES - Google Patents

PROCEDURE FOR PREPARING PIRIMIDIL-QUINAZOLINES

Info

Publication number
ES8202000A1
ES8202000A1 ES500738A ES500738A ES8202000A1 ES 8202000 A1 ES8202000 A1 ES 8202000A1 ES 500738 A ES500738 A ES 500738A ES 500738 A ES500738 A ES 500738A ES 8202000 A1 ES8202000 A1 ES 8202000A1
Authority
ES
Spain
Prior art keywords
formula
quinazolines
procedure
reaction
pirimidil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500738A
Other languages
Spanish (es)
Other versions
ES500738A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella AG
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella AG, Cassella Farbwerke Mainkur AG filed Critical Cassella AG
Publication of ES500738A0 publication Critical patent/ES500738A0/en
Publication of ES8202000A1 publication Critical patent/ES8202000A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Catching Or Destruction (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PIRIMIDIL-QUINAZOLINAS, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDO, EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE LA PIPERAZINA CON UN COMPUESTO DE FORMULA (II), SEGUIDA DE LA REACCION CON UN COMPUESTO DE FORMULA (III)), EN LAS QUE R1, R2 Y R3, TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); X ES HALOGENO O UN GRUPO MERCAPTO, T HAL ES HALOGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO, Y A UNA TEMPERATURA ENTRE 20 Y 160 C. LOS REACTIVOS (II) Y (III) SE PUEDEN HACER REACCIONAR CON LA PIPERAZINA EN EL ORDEN INVERSO.PROCEDURE FOR OBTAINING PYRIMIDIL-QUINAZOLINES, OF FORMULA (I), AND THEIR ACID ADDITION SALTS, IN WHICH R1, R2 AND R3 MAY BE VARIOUS TYPES OF RADICALS. CONSISTS OF THE REACTION OF PIPERAZINE WITH A COMPOUND OF FORMULA (II), FOLLOWED BY THE REACTION WITH A COMPOUND OF FORMULA (III)), IN WHICH R1, R2 AND R3 HAVE THE SAME MEANING AS IN FORMULA (I) ; X IS HALOGEN OR A MERCAPT GROUP, T HAL IS HALOGEN. THE REACTION IS CARRIED OUT IN AN INERT SOLVENT, IN THE PRESENCE OF AN ACID ACCEPTING AGENT, AND AT A TEMPERATURE BETWEEN 20 AND 160 C. REAGENTS (II) AND (III) MAY BE REACTED WITH PIPERAZINE IN THE REVERSE ORDER.

ES500738A 1980-03-27 1981-03-26 PROCEDURE FOR PREPARING PIRIMIDIL-QUINAZOLINES Expired ES8202000A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803011809 DE3011809A1 (en) 1980-03-27 1980-03-27 PYRIMIDYL-CHINAZOLINE, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING IT AND THEIR USE

Publications (2)

Publication Number Publication Date
ES500738A0 ES500738A0 (en) 1982-01-16
ES8202000A1 true ES8202000A1 (en) 1982-01-16

Family

ID=6098481

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500738A Expired ES8202000A1 (en) 1980-03-27 1981-03-26 PROCEDURE FOR PREPARING PIRIMIDIL-QUINAZOLINES

Country Status (18)

Country Link
EP (1) EP0037495A1 (en)
JP (1) JPS56150088A (en)
AR (1) AR227542A1 (en)
AU (1) AU6877481A (en)
CA (1) CA1156656A (en)
CS (1) CS219898B2 (en)
DD (1) DD157614A5 (en)
DE (1) DE3011809A1 (en)
DK (1) DK115581A (en)
ES (1) ES8202000A1 (en)
FI (1) FI810778A7 (en)
GR (1) GR71870B (en)
IL (1) IL62495A0 (en)
NO (1) NO810870L (en)
PL (2) PL230320A1 (en)
PT (1) PT72724B (en)
SU (1) SU1052158A3 (en)
ZA (1) ZA812034B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61140568A (en) * 1984-12-14 1986-06-27 Mitsui Petrochem Ind Ltd Quinazoline derivative, and hypotensor containing said derivative as active component
JPS6267077A (en) * 1985-09-18 1987-03-26 Mitsui Petrochem Ind Ltd Quinazoline derivative and pharmaceutical
CN102079743B (en) * 2004-03-15 2020-08-25 武田药品工业株式会社 dipeptidyl peptidase inhibitor
US7576076B2 (en) * 2004-07-02 2009-08-18 Corcept Therapeutics, Inc. Modified pyrimidine glucocorticoid receptor modulators
CN103596431B (en) 2011-03-18 2016-06-22 科赛普特治疗公司 Pyrimidine cyclohexyl glucocorticoid receptor modulators
CA3102099C (en) 2018-06-04 2023-09-26 Corcept Therapeutics Incorporated Pyrimidine cyclohexenyl glucocorticoid receptor modulators
JP7569492B2 (en) 2019-12-11 2024-10-18 コーセプト セラピューティクス， インコーポレイテッド Treatment of antipsychotic-induced weight gain with milicorilant
KR102911885B1 (en) 2020-05-06 2026-01-12 코어셉트 쎄라퓨틱스 인코포레이티드 Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
AU2021266739B2 (en) 2020-05-06 2024-11-28 Corcept Therapeutics Incorporated Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators
JP7853982B2 (en) 2020-12-21 2026-04-30 コーセプト セラピューティクス， インコーポレイテッド Method for preparing pyrimidine cyclohexylglucocorticoid receptor modulators
US12616698B2 (en) 2021-05-05 2026-05-05 Corcept Therapeutics Incorporated Methods for reducing liver fat and for treating fatty liver disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2007656B (en) * 1977-11-05 1982-05-19 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
SU1052158A3 (en) 1983-10-30
PT72724B (en) 1982-03-24
ZA812034B (en) 1982-05-26
IL62495A0 (en) 1981-05-20
CS219898B2 (en) 1983-03-25
AU6877481A (en) 1981-10-01
PL233882A1 (en) 1982-05-10
DK115581A (en) 1981-09-28
FI810778L (en) 1981-09-28
FI810778A7 (en) 1981-09-28
EP0037495A1 (en) 1981-10-14
DD157614A5 (en) 1982-11-24
JPS56150088A (en) 1981-11-20
DE3011809A1 (en) 1981-10-01
ES500738A0 (en) 1982-01-16
PL230320A1 (en) 1982-03-29
GR71870B (en) 1983-07-08
NO810870L (en) 1981-09-28
AR227542A1 (en) 1982-11-15
CA1156656A (en) 1983-11-08
PT72724A (en) 1981-04-01

Similar Documents

Publication Publication Date Title
ES8401970A1 (en) A PROCEDURE FOR THE PREPARATION OF BENZOISOTIAZOL AND BENZOISOXAZOL PIPERAZINE DERIVATIVES.
ES8306155A1 (en) 7-(substituted or unsubstituted amino) 3-substituted methyl-3cephem-4-carboxylic acid
ES8204428A1 (en) PROCEDURE FOR PREPARING ALPHA-ARIL-1H-1,2,4-TRIAZOL-1-ETHANOLS
ES8301980A1 (en) 8-Arylalkyl-3-phenyl-3-nortropanols, their acid addition salts, pharmaceutical compositions containing them and processes for their preparation.
ES8304095A1 (en) Anti-tumor quinazoline compounds
ES8400415A1 (en) Chloro- and alkoxy-substituted-2,4-diaminoquinazolines and pharmaceutical compositions containing them.
DK43882A (en) PROCEDURE FOR MADEING CEPHEM RELATIONS
ES8304096A1 (en) Pyrimidones, their preparation and medicines containing them.
ES8601992A1 (en) PROCEDURE FOR PREPARING 2-PHENYL-IMIDAZOLES
ES8603497A1 (en) PROCEDURE FOR PREPARING CEPHALOSPORIN DERIVATIVES
ES8306750A1 (en) 2-Guanidino-4-heteroarylthiazoles and pharmaceutical compositions containing them.
ES8307824A1 (en) A PROCEDURE FOR PREPARING NEW CEFEM COMPOUNDS.
ES8604215A1 (en) Ether prodrugs of anti-inflammatory oxicams.
ES8604529A1 (en) 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols
ES8305755A1 (en) PROCEDURE TO PREPARE PIRIMIDONE DERIVATIVES.
ES8201116A1 (en) PROCEDURE FOR PREPARING DERIVATIVES OF 2-NITRO-5- (SUBSTITUTED PHENOXY) -BENZOYL
ES8303427A1 (en) "A PROCEDURE FOR PREPARING CEFEM COMPOUNDS".
ES8205837A1 (en) Symmetrical unsubstituted and substituted 2-halo-4-(4'-(trisulfonaphthylazo)phenylamino)-1,3,5-triazin-6-ylamino compounds
SE8102337L (en) RADIORECEIVER
ES8607982A1 (en) Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same.
ES8606321A1 (en) Benzofuran derivatives, processes for preparing the same and antihypertensive agents containing the same.
ES484255A1 (en) A PROCEDURE FOR THE PREPARATION OF N-BENZYLNOCOLETAMIDE DERIVATIVES.
ES8702390A1 (en) A PROCEDURE FOR THE PREPARATION OF NEW 1,5-BENZOTIAZEPINE DERIVATIVES
ES8304976A1 (en) "PROCEDURE FOR THE PREPARATION OF SUBSTITUTED TRYPTAMINIC DERIVATIVES OF THENYLOXYPROPANOLAMINS, RACEMICS AND OPTICALLY ACTIVE".
ES8300741A1 (en) A PROCEDURE FOR THE PREPARATION OF THIOFEN-SULFONAMIDES WITH INSECTICIDE ACTIVITY.