ES8202000A1 - PROCEDURE FOR PREPARING PIRIMIDIL-QUINAZOLINES - Google Patents

PROCEDURE FOR PREPARING PIRIMIDIL-QUINAZOLINES

Info

Publication number
ES8202000A1
ES8202000A1 ES500738A ES500738A ES8202000A1 ES 8202000 A1 ES8202000 A1 ES 8202000A1 ES 500738 A ES500738 A ES 500738A ES 500738 A ES500738 A ES 500738A ES 8202000 A1 ES8202000 A1 ES 8202000A1
Authority
ES
Spain
Prior art keywords
formula
quinazolines
procedure
reaction
pirimidil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500738A
Other languages
Spanish (es)
Other versions
ES500738A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella AG
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella AG, Cassella Farbwerke Mainkur AG filed Critical Cassella AG
Publication of ES8202000A1 publication Critical patent/ES8202000A1/en
Publication of ES500738A0 publication Critical patent/ES500738A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Catching Or Destruction (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PIRIMIDIL-QUINAZOLINAS, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDO, EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE LA PIPERAZINA CON UN COMPUESTO DE FORMULA (II), SEGUIDA DE LA REACCION CON UN COMPUESTO DE FORMULA (III)), EN LAS QUE R1, R2 Y R3, TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); X ES HALOGENO O UN GRUPO MERCAPTO, T HAL ES HALOGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO, Y A UNA TEMPERATURA ENTRE 20 Y 160 C. LOS REACTIVOS (II) Y (III) SE PUEDEN HACER REACCIONAR CON LA PIPERAZINA EN EL ORDEN INVERSO.PROCEDURE FOR OBTAINING PYRIMIDIL-QUINAZOLINES, OF FORMULA (I), AND THEIR ACID ADDITION SALTS, IN WHICH R1, R2 AND R3 MAY BE VARIOUS TYPES OF RADICALS. CONSISTS OF THE REACTION OF PIPERAZINE WITH A COMPOUND OF FORMULA (II), FOLLOWED BY THE REACTION WITH A COMPOUND OF FORMULA (III)), IN WHICH R1, R2 AND R3 HAVE THE SAME MEANING AS IN FORMULA (I) ; X IS HALOGEN OR A MERCAPT GROUP, T HAL IS HALOGEN. THE REACTION IS CARRIED OUT IN AN INERT SOLVENT, IN THE PRESENCE OF AN ACID ACCEPTING AGENT, AND AT A TEMPERATURE BETWEEN 20 AND 160 C. REAGENTS (II) AND (III) MAY BE REACTED WITH PIPERAZINE IN THE REVERSE ORDER.

ES500738A 1980-03-27 1981-03-26 PROCEDURE FOR PREPARING PIRIMIDIL-QUINAZOLINES Granted ES500738A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803011809 DE3011809A1 (en) 1980-03-27 1980-03-27 PYRIMIDYL-CHINAZOLINE, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING IT AND THEIR USE

Publications (2)

Publication Number Publication Date
ES8202000A1 true ES8202000A1 (en) 1982-01-16
ES500738A0 ES500738A0 (en) 1982-01-16

Family

ID=6098481

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500738A Granted ES500738A0 (en) 1980-03-27 1981-03-26 PROCEDURE FOR PREPARING PIRIMIDIL-QUINAZOLINES

Country Status (18)

Country Link
EP (1) EP0037495A1 (en)
JP (1) JPS56150088A (en)
AR (1) AR227542A1 (en)
AU (1) AU6877481A (en)
CA (1) CA1156656A (en)
CS (1) CS219898B2 (en)
DD (1) DD157614A5 (en)
DE (1) DE3011809A1 (en)
DK (1) DK115581A (en)
ES (1) ES500738A0 (en)
FI (1) FI810778L (en)
GR (1) GR71870B (en)
IL (1) IL62495A0 (en)
NO (1) NO810870L (en)
PL (2) PL230320A1 (en)
PT (1) PT72724B (en)
SU (1) SU1052158A3 (en)
ZA (1) ZA812034B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61140568A (en) * 1984-12-14 1986-06-27 Mitsui Petrochem Ind Ltd Quinazoline derivative, and hypotensor containing said derivative as active component
JPS6267077A (en) * 1985-09-18 1987-03-26 Mitsui Petrochem Ind Ltd Quinazoline derivative and pharmaceutical
UA85871C2 (en) * 2004-03-15 2009-03-10 Такеда Фармасьютікал Компані Лімітед Dipeptidyl peptidase inhibitors
PT1778236E (en) * 2004-07-02 2010-10-19 Corcept Therapeutics Inc Modified pyrimidine glucocorticoid receptor modulators
DK2685827T3 (en) 2011-03-18 2016-05-17 Corcept Therapeutics Inc PYRIMIDIN -cyclohexyl- glucocorticoid receptor MODULATORS
CA3102099C (en) 2018-06-04 2023-09-26 Corcept Therapeutics Incorporated Pyrimidine cyclohexenyl glucocorticoid receptor modulators
PH12022551430A1 (en) 2019-12-11 2023-11-20 Corcept Therapeutics Inc Methods of treating antipsychotic-induced weight gain with miricorilant
CA3182272A1 (en) 2020-05-06 2021-11-11 Corcept Therapeutics Incorporated Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
WO2021226258A1 (en) 2020-05-06 2021-11-11 Corcept Therapeutics Incorporated Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators
MX2023007403A (en) 2020-12-21 2023-08-16 Corcept Therapeutics Inc Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2007656B (en) * 1977-11-05 1982-05-19 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
AR227542A1 (en) 1982-11-15
FI810778A7 (en) 1981-09-28
FI810778L (en) 1981-09-28
PT72724A (en) 1981-04-01
AU6877481A (en) 1981-10-01
CA1156656A (en) 1983-11-08
IL62495A0 (en) 1981-05-20
JPS56150088A (en) 1981-11-20
PL233882A1 (en) 1982-05-10
GR71870B (en) 1983-07-08
DK115581A (en) 1981-09-28
EP0037495A1 (en) 1981-10-14
PT72724B (en) 1982-03-24
ZA812034B (en) 1982-05-26
DE3011809A1 (en) 1981-10-01
NO810870L (en) 1981-09-28
SU1052158A3 (en) 1983-10-30
CS219898B2 (en) 1983-03-25
ES500738A0 (en) 1982-01-16
DD157614A5 (en) 1982-11-24
PL230320A1 (en) 1982-03-29

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