ES8202826A1 - Procedimiento para la produccion de una 5,10-dihidroimidazo (2,1-b) quinazolina - Google Patents

Procedimiento para la produccion de una 5,10-dihidroimidazo (2,1-b) quinazolina

Info

Publication number
ES8202826A1
ES8202826A1 ES497048A ES497048A ES8202826A1 ES 8202826 A1 ES8202826 A1 ES 8202826A1 ES 497048 A ES497048 A ES 497048A ES 497048 A ES497048 A ES 497048A ES 8202826 A1 ES8202826 A1 ES 8202826A1
Authority
ES
Spain
Prior art keywords
pharmology
formula
dihydroimidazo
quinazolines
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497048A
Other languages
English (en)
Other versions
ES497048A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8202826A1 publication Critical patent/ES8202826A1/es
Publication of ES497048A0 publication Critical patent/ES497048A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA 5,10-DIHIDROIMIDAZO (2,1-B) QUINAZOLINA, EN LOS QUE AL MENOS UN ATOMO DE CARBOMO DEL ANILO, DISTINTO DEL C-2, ESTA SUSTITUIDO, COMPUESTO DE FORMULA (I), EN LA QUE R1-R6 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1-R6 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); Y LOS RADICALES R( CON ALXOXI C1-4. LA REACCION SE REALIZA EN CONDICIONES ACIDAS, OPCIONALMENTE EN UN DISOLVENTE ORGANICO Y INERTE Y A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE REFLUJO DEL MEDIO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD CANDIOTONICA Y VASODILATADORA.
ES497048A 1979-11-24 1980-11-21 Procedimiento para la produccion de una 5,10-dihidroimidazo (2,1-b) quinazolina Granted ES497048A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1045379 1979-11-24

Publications (2)

Publication Number Publication Date
ES8202826A1 true ES8202826A1 (es) 1982-02-16
ES497048A0 ES497048A0 (es) 1982-02-16

Family

ID=4363385

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497048A Granted ES497048A0 (es) 1979-11-24 1980-11-21 Procedimiento para la produccion de una 5,10-dihidroimidazo (2,1-b) quinazolina

Country Status (12)

Country Link
US (1) US4372956A (es)
EP (1) EP0029559A3 (es)
JP (1) JPS5699486A (es)
AU (1) AU6460480A (es)
DK (1) DK499180A (es)
ES (1) ES497048A0 (es)
FI (1) FI803589A7 (es)
IL (1) IL61536A0 (es)
PT (1) PT72086B (es)
SU (1) SU980624A3 (es)
YU (1) YU298180A (es)
ZA (1) ZA807327B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5117061A (en) * 1985-04-03 1992-05-26 Ethyl Corporation Process of preparing substituted anilines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
USD1041943S1 (en) * 2022-05-12 2024-09-17 HC Systems, Inc. Toilet paper housing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE760013A (fr) * 1969-12-18 1971-06-08 Smith Kline French Lab Imidazo et pyrimido -(2,1-b)quinazolines, leurs procedes de preparationet compositions pharmaceutiques en contenant
US3745216A (en) * 1969-12-18 1973-07-10 Smith Kline French Lab Compositions and methods for producing hypotensive activity with imidazo and pyrimido(2,1-b)quinazoline compounds
SU445665A1 (ru) 1972-06-30 1974-10-05 Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе Способ получени производных имидазо=/1,2=в/=хиназолона-5
US3974165A (en) * 1974-02-21 1976-08-10 Bristol-Myers Company Hypotensive agents
JPS5752352B2 (es) * 1974-02-28 1982-11-06
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
JPS5448797A (en) * 1977-09-06 1979-04-17 Sumitomo Chem Co Ltd Tricyclic condensed pyrimidine derivative and its preparation
JPS5576878A (en) * 1978-11-14 1980-06-10 Sumitomo Chem Co Ltd Tricyclic condensed pyrimidine derivative and its acid addition salt

Also Published As

Publication number Publication date
DK499180A (da) 1981-05-25
SU980624A3 (ru) 1982-12-07
EP0029559A2 (en) 1981-06-03
ZA807327B (en) 1982-07-28
AU6460480A (en) 1981-05-28
FI803589L (fi) 1981-05-25
IL61536A0 (en) 1980-12-31
YU298180A (en) 1983-02-28
US4372956A (en) 1983-02-08
ES497048A0 (es) 1982-02-16
JPS5699486A (en) 1981-08-10
PT72086B (en) 1982-01-28
PT72086A (en) 1980-12-01
EP0029559A3 (en) 1981-09-30
FI803589A7 (fi) 1981-05-25

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