ES8203352A1 - Procedimiento para la preparacion de 1-(4-clorobencidril)-4-(2,3-dihidroxipropil)-piperacina - Google Patents

Procedimiento para la preparacion de 1-(4-clorobencidril)-4-(2,3-dihidroxipropil)-piperacina

Info

Publication number
ES8203352A1
ES8203352A1 ES502429A ES502429A ES8203352A1 ES 8203352 A1 ES8203352 A1 ES 8203352A1 ES 502429 A ES502429 A ES 502429A ES 502429 A ES502429 A ES 502429A ES 8203352 A1 ES8203352 A1 ES 8203352A1
Authority
ES
Spain
Prior art keywords
bishydroxypropyl
chlorobenzhydryl
piperazine
addition salts
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502429A
Other languages
English (en)
Spanish (es)
Other versions
ES502429A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Selvi and C SpA
Original Assignee
Selvi and C SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selvi and C SpA filed Critical Selvi and C SpA
Publication of ES502429A0 publication Critical patent/ES502429A0/es
Publication of ES8203352A1 publication Critical patent/ES8203352A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES502429A 1980-05-23 1981-05-22 Procedimiento para la preparacion de 1-(4-clorobencidril)-4-(2,3-dihidroxipropil)-piperacina Expired ES8203352A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22283/80A IT1140978B (it) 1980-05-23 1980-05-23 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche

Publications (2)

Publication Number Publication Date
ES502429A0 ES502429A0 (es) 1982-04-01
ES8203352A1 true ES8203352A1 (es) 1982-04-01

Family

ID=11194137

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502429A Expired ES8203352A1 (es) 1980-05-23 1981-05-22 Procedimiento para la preparacion de 1-(4-clorobencidril)-4-(2,3-dihidroxipropil)-piperacina

Country Status (8)

Country Link
JP (1) JPS5731678A (2)
BE (1) BE888811A (2)
DE (1) DE3118162C2 (2)
ES (1) ES8203352A1 (2)
FR (1) FR2482965A1 (2)
GB (1) GB2076403B (2)
IT (1) IT1140978B (2)
NL (1) NL8102361A (2)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3611276A1 (de) * 1986-04-04 1987-11-26 Unilever Nv Verpackung mit margarine oder aehnlichem brotaufstrich
JPH01226575A (ja) * 1988-02-25 1989-09-11 Mitsubishi Plastics Ind Ltd もずくの包装体
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
PT1395567E (pt) 2001-05-18 2009-03-26 Astrazeneca Ab Derivados de 4(fenil-piperazinil-metil)benzamida e sua utilização para o tratamento da ansiedade da dor ou de distúrbios gastrointestinais
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
KR101234421B1 (ko) 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
HU227074B1 (en) 2005-12-08 2010-06-28 Egis Gyogyszergyar Nyrt An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
ES2361343T3 (es) * 2007-11-21 2011-06-16 Synthon B.V. Procedimiento para obtener n-(difenilmetil)piperazinas.

Also Published As

Publication number Publication date
BE888811A (nl) 1981-08-28
JPS5731678A (en) 1982-02-20
DE3118162A1 (de) 1982-02-18
ES502429A0 (es) 1982-04-01
GB2076403B (en) 1983-11-16
IT1140978B (it) 1986-10-10
JPS6135189B2 (2) 1986-08-12
NL8102361A (nl) 1981-12-16
DE3118162C2 (de) 1984-07-26
IT8022283A0 (it) 1980-05-23
FR2482965A1 (fr) 1981-11-27
FR2482965B1 (2) 1984-11-23
GB2076403A (en) 1981-12-02

Similar Documents

Publication Publication Date Title
ES8203352A1 (es) Procedimiento para la preparacion de 1-(4-clorobencidril)-4-(2,3-dihidroxipropil)-piperacina
IE40678B1 (en) 1-(3-(naphth-1-yloxy)-2-hydroxypropyl)piperazine derivatives
ES8400422A1 (es) "procedimiento de preparacion de eteres triciclicos, asi como de sus sales de adicion con un acido mineral u organico terapeuticamente compatible".
GEP20002210B (en) Acridine Derivatives
AU4017893A (en) New 1,4-disubstituted piperazine, a process for their preparation and pharmaceutical compositions containing them
ATE38991T1 (de) In 2-stellung substituierte 1,3propyledendephosphonat-derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
MX9800483A (es) Derivados de piperazina y su uso como antagonistas de 5-ht1a.
ES8701752A1 (es) Un procedimiento para preparar derivados de bencimidazol
ES8403910A1 (es) Procedimiento para la preparacion de nitratos de amino-deso-xi-1.4;3.6-dianhidro-hexito,asi como de sus sales de adicionacida farmacologicamente inocuas
AU543677B2 (en) 5,10-dihyro-11h-dibenzo(b,e)(1,4)diazepine-11-ones
NO960632L (no) Nye bis-naftalimider for behandling av kreft
AU648924B2 (en) New 1-(alkoxybenzyl)piperazine amide compounds, processes for preparing them and pharmaceutical compositions containing them
ATE21101T1 (de) N-iminopyridinium-betain-derivate, ihre herstellung und ihre verwendung als arzneimittel.
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
ES8801633A1 (es) Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo
JPS6447776A (en) 1-(2-(phenylmethyl)phenyl)piperazine compound, manufacture and medicinal composition
ES8704935A1 (es) Procedimiento para preparar derivados de fenilpiperazina
DE3560830D1 (en) Compounds having peripheral calcium antagonist, anticonvulsive and eumetabolic activity, processes for the preparation thereof and pharmaceutical compositions containing them
ES8608527A1 (es) Derivados anillados de 4h-1,4-benzotiazina
IE40679B1 (en) 1-(3-(napth-1-yloxy)-propyl)-piperazine derivatives
ES8301933A1 (es) "procedimiento para la preparacion de derivados de 4-(5)-alcohil-mercaptoimidazoles".
ES382616A1 (es) Procedimiento para la preparacion de nuevos derivados de i-midazolidinona.
FR2229404A1 (en) 1-(3,4,5-Trimethoxyphenyl)indoles - with bronchodilator, divretoc, anticholinergic, antidepressant, analgesic, antiinflammatory and sedative activity
JPS5422379A (en) Preparation of piperazine derivative
IL60518A0 (en) Substituted piperazine and piperidine derivatives and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603