ES8205201A1 - Un procedimiento para la preparacion de 4-alquil-sustituido-3--hidroxi-3-pirrolin-2,5 dionas. - Google Patents

Un procedimiento para la preparacion de 4-alquil-sustituido-3--hidroxi-3-pirrolin-2,5 dionas.

Info

Publication number
ES8205201A1
ES8205201A1 ES501077A ES501077A ES8205201A1 ES 8205201 A1 ES8205201 A1 ES 8205201A1 ES 501077 A ES501077 A ES 501077A ES 501077 A ES501077 A ES 501077A ES 8205201 A1 ES8205201 A1 ES 8205201A1
Authority
ES
Spain
Prior art keywords
alkylsubstituted
pyrroline
kidney
hydroxy
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501077A
Other languages
English (en)
Other versions
ES501077A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8205201A1 publication Critical patent/ES8205201A1/es
Publication of ES501077A0 publication Critical patent/ES501077A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 4-ALQUIL-SUSTITUIDO-3-HIDROXI-3-PIRROLIN-2,5-DIONAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES ALQUILO C6-16. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA RCH2CN, EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I), CON AXALATO DE DIETILO, EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, TAL COMO T-BUTOXIDO POTASICO, A UNA TEMPERATURA ENTRE LA AMBIENTE Y 60 GRADOS CENTIGRADOS, SEGUIDA DE LA HIDROLISIS CATALIZADA POR ACIDOS Y REACCION DE CICLACION POR CALENTAMIENTO PROLONGADO A 60 GRADOS CENTIGRADOS.
ES501077A 1980-04-04 1981-04-03 Un procedimiento para la preparacion de 4-alquil-sustituido-3--hidroxi-3-pirrolin-2,5 dionas. Granted ES501077A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/137,345 US4428959A (en) 1980-04-04 1980-04-04 4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

Publications (2)

Publication Number Publication Date
ES8205201A1 true ES8205201A1 (es) 1982-06-01
ES501077A0 ES501077A0 (es) 1982-06-01

Family

ID=22476981

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501077A Granted ES501077A0 (es) 1980-04-04 1981-04-03 Un procedimiento para la preparacion de 4-alquil-sustituido-3--hidroxi-3-pirrolin-2,5 dionas.

Country Status (8)

Country Link
US (1) US4428959A (es)
EP (1) EP0037991B1 (es)
JP (1) JPS56154459A (es)
DE (1) DE3160632D1 (es)
DK (1) DK153181A (es)
ES (1) ES501077A0 (es)
GR (1) GR74130B (es)
PT (1) PT72772B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) * 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
HUE032891T2 (hu) 2012-12-17 2017-11-28 Parion Sciences Inc Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
RU2671976C2 (ru) 2012-12-17 2018-11-08 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
WO2016123012A1 (en) 2015-01-26 2016-08-04 Wake Forest University Health Sciences Hypdh inhibitors and methods of use for the treatment of kidney stones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129225A (en) 1961-06-07 1964-04-14 Us Vitamin Pharm Corp Novel 4-oxy-3-maleimidyl betaines
DE1445664A1 (de) 1963-07-04 1969-11-27 Klinke Desitin Werk Verfahren zur Herstellung von alpha,alpha-disubstituierten Succinimiden
US3340263A (en) 1964-02-14 1967-09-05 Ciba Geigy Corp Amino-pyrroles
US3948941A (en) 1973-10-26 1976-04-06 Exxon Research And Engineering Company Preparation of imides using CN- catalysts
US4194982A (en) 1978-07-03 1980-03-25 Texaco Inc. N-sulfonylated polyalkenylsuccinimide and lubricant composition
US4256758A (en) * 1979-06-11 1981-03-17 Merck & Co., Inc. 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

Also Published As

Publication number Publication date
EP0037991A1 (en) 1981-10-21
PT72772A (en) 1981-04-01
JPS56154459A (en) 1981-11-30
DK153181A (da) 1981-10-05
US4428959A (en) 1984-01-31
EP0037991B1 (en) 1983-07-20
ES501077A0 (es) 1982-06-01
PT72772B (en) 1983-02-08
DE3160632D1 (en) 1983-08-25
GR74130B (es) 1984-06-06

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