ES8601932A1 - Un procedimiento para la preparacion de derivados de 1,2,4- triazol que contienen fluor - Google Patents

Un procedimiento para la preparacion de derivados de 1,2,4- triazol que contienen fluor

Info

Publication number
ES8601932A1
ES8601932A1 ES540857A ES540857A ES8601932A1 ES 8601932 A1 ES8601932 A1 ES 8601932A1 ES 540857 A ES540857 A ES 540857A ES 540857 A ES540857 A ES 540857A ES 8601932 A1 ES8601932 A1 ES 8601932A1
Authority
ES
Spain
Prior art keywords
derivatives
procedure
preparation
containing fluorine
triazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540857A
Other languages
English (en)
Other versions
ES540857A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of ES540857A0 publication Critical patent/ES540857A0/es
Publication of ES8601932A1 publication Critical patent/ES8601932A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1,2,4-TRIAZOL QUE CONTIENE FLUOR.CONSISTENTE EN HACER REACCIONAR 1,2,4-TRIAZOL O UNA SOLUCION METALICA DEL MISMO CON UN COMPUESTO DE FORMULA (II) PARA OBTENER UN COMPUESTO DE FORMULA (I) Y/O SU SOLUCION FARMACEUTICAMENTE ACEPTABLE. LA REACCION SE PRODUCE EN PRESENCIA DE CARBONATO POTASICO Y EN UN DISOLVENTE ORGANICO A UNA TEMPERATURA DE HASTA 130 C; SIENDO R UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO CON 1 A 3 SUSTITUYENTES SELECCIONADOS ENTRE F, C1, BR, 1 Y TRIFLUOROMETILO.SE UTILIZARON POR SU ACTIVIDAD ANTIFUNGICA EN EL TRATAMIENTO DE INFECCIONES FUNGICAS EN LOS ANIMALES, INCLUIDO EL HOMBRE Y COMO FUNGICIDAS AGRICOLAS.
ES540857A 1982-08-14 1985-03-01 Un procedimiento para la preparacion de derivados de 1,2,4- triazol que contienen fluor Expired ES8601932A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8223459 1982-08-14
GB8231309 1982-11-02

Publications (2)

Publication Number Publication Date
ES540857A0 ES540857A0 (es) 1985-11-16
ES8601932A1 true ES8601932A1 (es) 1985-11-16

Family

ID=26283600

Family Applications (2)

Application Number Title Priority Date Filing Date
ES524873A Expired ES8600256A1 (es) 1982-08-14 1983-08-11 Un procedimiento para la preparacion de un compuesto antifungico
ES540857A Expired ES8601932A1 (es) 1982-08-14 1985-03-01 Un procedimiento para la preparacion de derivados de 1,2,4- triazol que contienen fluor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES524873A Expired ES8600256A1 (es) 1982-08-14 1983-08-11 Un procedimiento para la preparacion de un compuesto antifungico

Country Status (22)

Country Link
US (1) US4616027A (es)
EP (1) EP0104734B1 (es)
KR (1) KR880001046B1 (es)
AU (1) AU542692B2 (es)
CA (1) CA1249827A (es)
DD (1) DD207715A5 (es)
DE (1) DE3372481D1 (es)
DK (1) DK162842C (es)
ES (2) ES8600256A1 (es)
FI (1) FI82933C (es)
GR (1) GR78905B (es)
HU (1) HU188943B (es)
IE (1) IE55845B1 (es)
IL (1) IL69485A (es)
IN (1) IN160173B (es)
NO (1) NO159086C (es)
NZ (1) NZ205243A (es)
PH (1) PH18645A (es)
PL (2) PL139633B1 (es)
PT (1) PT77193B (es)
SU (1) SU1468416A3 (es)
YU (1) YU42874B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BG48681A3 (bg) * 1982-12-14 1991-04-15 Ciba - Geigy Ag Фунгицидно средство
GB8302498D0 (en) * 1983-01-29 1983-03-02 Pfizer Ltd Antifungal agents
US4584307A (en) * 1983-08-10 1986-04-22 Pfizer Inc. Antifungal 2-aryl-2-hydroxy perfluoro-1-(1H-1,2,4-triazol-1-yl) alkanones and alkanols
GB8322983D0 (en) * 1983-08-26 1983-09-28 Pfizer Ltd Triazole antifungal agents
FR2622582B1 (fr) * 1987-10-29 1990-01-19 Rhone Poulenc Agrochimie Composes a groupe imidazole ou triazole, utilisation de ceux-ci a titre de fongicide, procede de preparation
IT1186784B (it) * 1985-11-04 1987-12-16 Montedison Spa Azoliderivati ad attivita' antufungina
IT1196528B (it) * 1986-07-21 1988-11-16 Donegani Guido Ist Azolilderivati ad attivita' antifungina
IT1198240B (it) * 1986-12-23 1988-12-21 Agrimont Spa Azolilderivati fungicidi
KR910700237A (ko) * 1989-01-23 1991-03-14 리챠드 지. 워터맨 치환된 트리아졸, 그의 제조방법 및 살진균제로서 사용하기 위한 조성물
US5262434A (en) * 1990-08-09 1993-11-16 Bayer Aktiengesellschaft Halogenoalkyl-azolyl derivatives
EP0470466A3 (en) * 1990-08-09 1992-07-29 Bayer Ag Halogenalkyl-azolyl derivatives
JP3471831B2 (ja) * 1991-12-09 2003-12-02 富山化学工業株式会社 新規なトリアゾール誘導体およびその塩
US5611210A (en) * 1993-03-05 1997-03-18 Ikon Corporation Fluoroiodocarbon blends as CFC and halon replacements
US6270689B1 (en) 1998-03-26 2001-08-07 Ikon Corporation Blend compositions of trifluoroiodomethane, tetrafluoroethane and difluoroethane
US9095589B2 (en) 2007-04-05 2015-08-04 Johns Hopkins University Chirally pure isomers of itraconazole for use as angiogenesis inhibitors
US20110262517A1 (en) * 2007-04-05 2011-10-27 The Johns Hopkins University Chirally pure isomers of itraconazole and inhibitors of lanosterol 14a-demethylase for use as angiogenesis inhibitors
WO2014095548A1 (en) * 2012-12-19 2014-06-26 Basf Se Substituted [1,2,4]triazole compounds and their use as fungicides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE45765B1 (en) * 1976-08-19 1982-11-17 Ici Ltd Triazoles and imidazoles useful as plant fungicides and growth regulating agents
DE2832234A1 (de) * 1978-07-21 1980-01-31 Bayer Ag Alpha -azolyl-keto-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4654332A (en) * 1979-03-07 1987-03-31 Imperial Chemical Industries Plc Heterocyclic compounds
DE2951164A1 (de) * 1979-12-19 1981-07-16 Bayer Ag, 5090 Leverkusen Substituierte triazolylmethyl-tert.-butyl-ketone, verfahren zu ihrer herstellung und ihre verwendung als pflanzenschutzmittel sowie als zwischenprodukte
EP0131684B1 (en) * 1980-08-18 1992-03-11 Imperial Chemical Industries Plc Use of triazolylethanol derivatives and their compositions as non-agricultural fungicides
DE3167205D1 (en) * 1980-08-28 1984-12-20 Ici Plc Pharmaceutical compositions of fungicidal triazole derivatives

Also Published As

Publication number Publication date
GR78905B (es) 1984-10-02
FI832904L (fi) 1984-02-15
IN160173B (es) 1987-06-27
NO832915L (no) 1984-02-15
DE3372481D1 (en) 1987-08-20
IE55845B1 (en) 1991-01-30
FI832904A0 (fi) 1983-08-11
YU168283A (en) 1986-02-28
KR880001046B1 (ko) 1988-06-18
PT77193A (en) 1983-09-01
DK162842C (da) 1992-05-04
IL69485A (en) 1987-09-16
PL140540B1 (en) 1987-05-30
SU1468416A3 (ru) 1989-03-23
EP0104734B1 (en) 1987-07-15
ES540857A0 (es) 1985-11-16
NZ205243A (en) 1986-04-11
ES524873A0 (es) 1985-10-01
AU542692B2 (en) 1985-03-07
CA1249827A (en) 1989-02-07
PL139633B1 (en) 1987-02-28
US4616027A (en) 1986-10-07
DD207715A5 (de) 1984-03-14
IL69485A0 (en) 1983-11-30
FI82933B (fi) 1991-01-31
PH18645A (en) 1985-08-23
DK367883D0 (da) 1983-08-12
ES8600256A1 (es) 1985-10-01
AU1793083A (en) 1984-02-16
DK367883A (da) 1984-02-15
DK162842B (da) 1991-12-16
PL243409A1 (en) 1985-07-16
NO159086C (no) 1988-11-30
YU42874B (en) 1988-12-31
EP0104734A1 (en) 1984-04-04
PT77193B (en) 1986-03-21
KR840005719A (ko) 1984-11-15
FI82933C (fi) 1991-05-10
NO159086B (no) 1988-08-22
IE831889L (en) 1984-02-14
PL252362A1 (en) 1985-11-19
HU188943B (en) 1986-05-28

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