ES8207175A1 - Un procedimiento para la preparacion de fenil-quinolicidinas - Google Patents

Un procedimiento para la preparacion de fenil-quinolicidinas

Info

Publication number
ES8207175A1
ES8207175A1 ES501232A ES501232A ES8207175A1 ES 8207175 A1 ES8207175 A1 ES 8207175A1 ES 501232 A ES501232 A ES 501232A ES 501232 A ES501232 A ES 501232A ES 8207175 A1 ES8207175 A1 ES 8207175A1
Authority
ES
Spain
Prior art keywords
quinolicidins
phenyl
procedure
preparation
alcoxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501232A
Other languages
English (en)
Other versions
ES501232A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES501232A0 publication Critical patent/ES501232A0/es
Publication of ES8207175A1 publication Critical patent/ES8207175A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

U PROCEDIMIENTO PARA LA PREPARACION DE FENIL-QUINOLICIDINAS. CONSISTE ENOSCILAR UNA MINA PRIMARIA O SECUNDARIA DE FORMULA GENERAL (I); SI SE DESEA, SE PUEDEN RESOLVER LOS RACEMATOS OBTENIDOS O SE TRANSFORMAN LAS BASES EN SALES DE ADICION DE ACIDO. SE OBTIENE EL COMPUESTO (II) EN QUE X ES HIDROGENO, FLUOR, CLORO, ALCOXILO, O TRIFLUORMETILO; Y ES HIDROGENO, FLUOR, CLORO, ALCOXILO O ALQUILO; R'''' ES ACILAMINO, PROPINANILIDO O 4''-FLUOROPROPIONANILIDO.
ES501232A 1980-04-11 1981-04-10 Un procedimiento para la preparacion de fenil-quinolicidinas Expired ES8207175A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH278480 1980-04-11
CH70181 1981-02-03

Publications (2)

Publication Number Publication Date
ES501232A0 ES501232A0 (es) 1982-09-16
ES8207175A1 true ES8207175A1 (es) 1982-09-16

Family

ID=25685419

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501232A Expired ES8207175A1 (es) 1980-04-11 1981-04-10 Un procedimiento para la preparacion de fenil-quinolicidinas

Country Status (18)

Country Link
US (2) US4391978A (es)
EP (1) EP0037990B1 (es)
AU (1) AU540599B2 (es)
CA (1) CA1142933A (es)
CS (1) CS222696B2 (es)
DE (1) DE3167549D1 (es)
DK (1) DK116181A (es)
ES (1) ES8207175A1 (es)
FI (1) FI67700C (es)
HU (1) HU185633B (es)
IE (1) IE51108B1 (es)
IL (1) IL62592A (es)
MC (1) MC1392A1 (es)
NO (1) NO153258C (es)
NZ (1) NZ196682A (es)
PH (1) PH19199A (es)
PT (1) PT72840B (es)
ZW (1) ZW5581A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
EP0094744A1 (en) * 1982-04-23 1983-11-23 Beecham Group Plc Azabicyclobenzamides, their preparation and their pharmaceutical compositions
US4716172A (en) * 1986-04-10 1987-12-29 Mcneilab, Inc. 4-substituted octahydroquinolizine analgesic compounds and octahydroquinolizinium intermediates
US6770658B2 (en) 1998-09-09 2004-08-03 Inflazyme Pharmaceuticals Ltd. Substituted γ-phenyl-Δ-lactams and uses related thereto
JP4842963B2 (ja) * 2004-11-30 2011-12-21 エフ．ホフマン−ラ ロシュ アーゲー 糖尿病を処置するｄｐｐ−ｉｖ阻害剤としての置換ベンゾキノリジン
WO2019134985A1 (en) * 2018-01-08 2019-07-11 F. Hoffmann-La Roche Ag Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3394141A (en) * 1965-11-12 1968-07-23 Fabio Sparatore Z-benzyaminobenzimidazoles
US3852452A (en) * 1970-02-10 1974-12-03 Ayerst Mckenna & Harrison Benzocycloheptaisoquinoline derivatives as cns depressants
US3692791A (en) * 1970-05-18 1972-09-19 American Home Prod SUBSTITUTED 2-t-BUTYL-OCTAHYDRO-2H-QUINOLIZINES
US3948923A (en) * 1972-03-06 1976-04-06 Bayer Aktiengesellschaft Pentahydroqunolizine derivatives
US3997547A (en) * 1975-07-14 1976-12-14 Morton-Norwich Products, Inc. Phenylimino-2H-quinolizines
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
NZ191763A (en) * 1978-10-13 1984-05-31 Hoffmann La Roche 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
US4339582A (en) * 1981-08-18 1982-07-13 Miles Laboratories, Inc. Quinolizidine-propionanilide compounds

Also Published As

Publication number Publication date
DE3167549D1 (en) 1985-01-17
PH19199A (en) 1986-01-31
NO153258C (no) 1986-02-12
ZW5581A1 (en) 1981-11-18
FI811102L (fi) 1981-10-12
NO811263L (no) 1981-10-12
IE51108B1 (en) 1986-10-01
EP0037990B1 (de) 1984-12-05
FI67700B (fi) 1985-01-31
NO153258B (no) 1985-11-04
ES501232A0 (es) 1982-09-16
HU185633B (en) 1985-03-28
FI67700C (fi) 1985-05-10
MC1392A1 (fr) 1982-04-27
CA1142933A (en) 1983-03-15
CS222696B2 (en) 1983-07-29
PT72840B (en) 1983-01-10
DK116181A (da) 1981-10-12
AU540599B2 (en) 1984-11-29
AU6910781A (en) 1981-10-15
US4391978A (en) 1983-07-05
NZ196682A (en) 1984-03-30
EP0037990A1 (de) 1981-10-21
US4684731A (en) 1987-08-04
IL62592A0 (en) 1981-06-29
PT72840A (en) 1981-05-01
IL62592A (en) 1984-12-31
IE810822L (en) 1981-10-11

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