ES8207177A1 - Procedimiento para preparar nuevos derivados de triazoloqui-nazolinona - Google Patents
Procedimiento para preparar nuevos derivados de triazoloqui-nazolinonaInfo
- Publication number
- ES8207177A1 ES8207177A1 ES499393A ES499393A ES8207177A1 ES 8207177 A1 ES8207177 A1 ES 8207177A1 ES 499393 A ES499393 A ES 499393A ES 499393 A ES499393 A ES 499393A ES 8207177 A1 ES8207177 A1 ES 8207177A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- preparation
- addition salts
- acid addition
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- JDPSKZFCBMHFKL-UHFFFAOYSA-N triazolo[4,5-h]quinazolin-4-one Chemical class O=C1C=C2C=NC=NC2=C2C1=NN=N2 JDPSKZFCBMHFKL-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000000572 bronchospasmolytic effect Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Paints Or Removers (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE TRAIZOLOQUINAZOLINONA. CONSISTE EN HACER REACCIONAR EL COMPUESTO (I) CON NH2-(CH2)N-OH PARA OBTENER EL COMPUESTO (II), EL CUAL, A SU VEZ, SE HACE REACCIONAR CON UN AGENTE FORMILANTE CON LO QUE SE OBTIENE EL COMPUESTO (III) QUE SE HACE REACCIONAR CON UN AGENTE HALOGENANTE PARA DAR EL COMPUESTO (V), EL CUAL, POR ULTIMO, SE HACE REACCIONAR CON EL COMPUESTO (V) PARA OBTENER LOS ERIVADOS DE TRIAZOLOQUINAZOLINONA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8005089 | 1980-02-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8207177A1 true ES8207177A1 (es) | 1982-09-01 |
| ES499393A0 ES499393A0 (es) | 1982-09-01 |
Family
ID=10511371
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES499393A Granted ES499393A0 (es) | 1980-02-14 | 1981-02-13 | Procedimiento para preparar nuevos derivados de triazoloqui-nazolinona |
| ES509536A Granted ES509536A0 (es) | 1980-02-14 | 1982-02-12 | "procedimiento para preparar nuevos derivados de triazoloquinazolinona". |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509536A Granted ES509536A0 (es) | 1980-02-14 | 1982-02-12 | "procedimiento para preparar nuevos derivados de triazoloquinazolinona". |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4350695A (es) |
| EP (1) | EP0034529B1 (es) |
| JP (1) | JPS56128784A (es) |
| AT (1) | ATE4211T1 (es) |
| AU (1) | AU544275B2 (es) |
| CA (1) | CA1156228A (es) |
| DE (1) | DE3160621D1 (es) |
| DK (1) | DK155883C (es) |
| ES (2) | ES499393A0 (es) |
| FI (1) | FI69307C (es) |
| GB (1) | GB2069495B (es) |
| GR (1) | GR74418B (es) |
| HU (1) | HU182609B (es) |
| IE (1) | IE50918B1 (es) |
| PT (1) | PT72501B (es) |
| ZA (1) | ZA81708B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2976027A (en) * | 1955-07-02 | 1961-03-21 | Allimann Georges | Drilling-head for the sinking of shafts, galleries and the like |
| IL64012A (en) * | 1980-11-10 | 1986-09-30 | Roussel Uclaf | Process for the preparation of triazoloquinazolinone and some novel 3-amino-2-(amino-alkylamino)-4(3h)quinazolinone derivatives therefor |
| IL66835A (en) * | 1981-09-24 | 1988-05-31 | Roussel Uclaf | 1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing them |
| JPS5883012A (ja) * | 1981-11-11 | 1983-05-18 | Japan Synthetic Rubber Co Ltd | １―アセトキシ―１，３―ブタジエンの重合体組成物 |
| US5334592A (en) * | 1988-04-27 | 1994-08-02 | Schering Corporation | Certain PAF antagonist antihistamine combinations and methods |
| CN108976235B (zh) * | 2018-09-30 | 2019-09-17 | 遵义医科大学 | 一种喹唑啉酮类化合物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3850932A (en) * | 1973-06-28 | 1974-11-26 | Sandoz Ag | 5-(2-carboxy and 2-carboalkoxy-phenylamino)-1,2,4-triazolo-quinazolines |
| SU578314A1 (ru) * | 1976-06-28 | 1977-10-30 | Запорожский Государственный Медицинсккий Институт Министерства Здравоохранения Украинской Сср | Гидрохлорид 1-( -диэтиламиноэтил) -2-метилимидазо /2,1- / хиназолин -5 (1н) -она,про вл ющий гипотензивное действие |
| DE2757929A1 (de) * | 1977-12-24 | 1979-07-05 | Boehringer Sohn Ingelheim | Neue pyrido-eckige klammer auf 1,2-a eckige klammer zu -v-triazolo- eckige klammer auf 4,5-d eckige klammer zu pyrimidinone, deren salze und verfahren zu deren herstellung |
-
1981
- 1981-02-03 ZA ZA00810708A patent/ZA81708B/xx unknown
- 1981-02-10 EP EP81400204A patent/EP0034529B1/fr not_active Expired
- 1981-02-10 DE DE8181400204T patent/DE3160621D1/de not_active Expired
- 1981-02-10 AT AT81400204T patent/ATE4211T1/de not_active IP Right Cessation
- 1981-02-12 AU AU67221/81A patent/AU544275B2/en not_active Ceased
- 1981-02-12 FI FI810426A patent/FI69307C/fi not_active IP Right Cessation
- 1981-02-12 GR GR64106A patent/GR74418B/el unknown
- 1981-02-13 ES ES499393A patent/ES499393A0/es active Granted
- 1981-02-13 US US06/234,544 patent/US4350695A/en not_active Expired - Fee Related
- 1981-02-13 GB GB8104493A patent/GB2069495B/en not_active Expired
- 1981-02-13 HU HU81356A patent/HU182609B/hu not_active IP Right Cessation
- 1981-02-13 JP JP1917181A patent/JPS56128784A/ja active Pending
- 1981-02-13 CA CA000370869A patent/CA1156228A/en not_active Expired
- 1981-02-13 DK DK062281A patent/DK155883C/da active
- 1981-02-13 IE IE290/81A patent/IE50918B1/en unknown
- 1981-02-13 PT PT72501A patent/PT72501B/pt unknown
-
1982
- 1982-02-12 ES ES509536A patent/ES509536A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IE50918B1 (en) | 1986-08-20 |
| GB2069495B (en) | 1984-01-18 |
| FI69307C (fi) | 1986-01-10 |
| FI810426L (fi) | 1981-08-15 |
| GB2069495A (en) | 1981-08-26 |
| DK62281A (da) | 1981-08-15 |
| EP0034529B1 (fr) | 1983-07-20 |
| HU182609B (en) | 1984-02-28 |
| IE810290L (en) | 1981-08-14 |
| FI69307B (fi) | 1985-09-30 |
| ZA81708B (en) | 1982-06-30 |
| US4350695A (en) | 1982-09-21 |
| PT72501A (en) | 1981-03-01 |
| ES8304133A1 (es) | 1983-02-16 |
| JPS56128784A (en) | 1981-10-08 |
| AU6722181A (en) | 1981-09-24 |
| EP0034529A1 (fr) | 1981-08-26 |
| DK155883C (da) | 1989-10-09 |
| ATE4211T1 (de) | 1983-08-15 |
| CA1156228A (en) | 1983-11-01 |
| GR74418B (es) | 1984-06-28 |
| DE3160621D1 (en) | 1983-08-25 |
| ES499393A0 (es) | 1982-09-01 |
| ES509536A0 (es) | 1983-02-16 |
| PT72501B (en) | 1982-10-14 |
| DK155883B (da) | 1989-05-29 |
| AU544275B2 (en) | 1985-05-23 |
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