ES8207526A1 - Un procedimiento para la preparacion de nuevos derivados de la quinoleina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de la quinoleina.Info
- Publication number
- ES8207526A1 ES8207526A1 ES507998A ES507998A ES8207526A1 ES 8207526 A1 ES8207526 A1 ES 8207526A1 ES 507998 A ES507998 A ES 507998A ES 507998 A ES507998 A ES 507998A ES 8207526 A1 ES8207526 A1 ES 8207526A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- piperidyl
- quinolyl
- medicines
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title abstract 2
- SJPWBZYZHVUQRD-UHFFFAOYSA-N 2-piperidin-4-yl-1-quinolin-4-ylethanone Chemical class C=1C=NC2=CC=CC=C2C=1C(=O)CC1CCNCC1 SJPWBZYZHVUQRD-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINOLEINA DE FORMULA (I), EN LA QUE R1 ES HIDROGENO O ALQUILO C1-4 X Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE MONOCLOROCARBENO CON UN DERIVADO DE INDOL, DE FORMULA (II), EN LA QUE R1 Y R2 Y X TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO PREPARANDO EL MONOCLOROCARBENO "IN SITU" POR ACCION DE UNA BASE, TAL COMO METILLITIO SOBRE DICLOROMETANO EN UN DISOLVENTE INERTE A UNA TEMPERATURA ENTRE 30 Y 20 C. ESTOS COMPUESTOS TIENEN APLICACIONES COMO PRODUCTOS INTERMEDIOS PARA LA FABRICACION DE MEDICAMENTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7931396A FR2471981A1 (fr) | 1979-12-21 | 1979-12-21 | Nouveaux derives de la (piperidyl-4)-2 (quinolyl-4)-1 ethanone, produits intermediaires et procedes pour leur preparation, et leur utilisation comme medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8207526A1 true ES8207526A1 (es) | 1982-10-01 |
| ES507998A0 ES507998A0 (es) | 1982-10-01 |
Family
ID=9233056
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498017A Granted ES498017A0 (es) | 1979-12-21 | 1980-12-19 | Un procedimiento para la preparacion de nuevos derivados de la quinoleina. |
| ES507998A Granted ES507998A0 (es) | 1979-12-21 | 1981-12-15 | Un procedimiento para la preparacion de nuevos derivados de la quinoleina. |
| ES507997A Expired ES8207525A1 (es) | 1979-12-21 | 1981-12-15 | Un procedimiento para la preparacion de nuevos derivados de la quinoleina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498017A Granted ES498017A0 (es) | 1979-12-21 | 1980-12-19 | Un procedimiento para la preparacion de nuevos derivados de la quinoleina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507997A Expired ES8207525A1 (es) | 1979-12-21 | 1981-12-15 | Un procedimiento para la preparacion de nuevos derivados de la quinoleina. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US4433150A (es) |
| EP (1) | EP0031753B1 (es) |
| JP (1) | JPS5699476A (es) |
| AT (1) | AT376670B (es) |
| CA (1) | CA1178589A (es) |
| DE (1) | DE3069243D1 (es) |
| DK (1) | DK530480A (es) |
| ES (3) | ES498017A0 (es) |
| FR (1) | FR2471981A1 (es) |
| IE (1) | IE51124B1 (es) |
| NO (1) | NO155137C (es) |
| PT (1) | PT72212A (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7908031A (nl) * | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen. |
| US4442107A (en) * | 1980-03-06 | 1984-04-10 | Acf Chemiefarma N.V. | Quinoline derivatives, pharmaceutical compositions containing such compounds, and methods for treating cardiovascular conditions with them |
| FR2495470A1 (fr) * | 1980-12-05 | 1982-06-11 | Pharmindustrie | Nouveaux medicaments a base de derives de (quinolyl-4)-1 (piperidyl-4)-2 ethanol ou (quinolyl-4)-1 (piperidyl-4)-3 propanol |
| FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| WO1999043681A1 (en) | 1998-02-26 | 1999-09-02 | Neurogen Corporation | 4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands |
| GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| GB9917408D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| AR037641A1 (es) * | 2001-12-05 | 2004-11-17 | Tularik Inc | Moduladores de inflamacion |
| US7312212B2 (en) | 2002-01-29 | 2007-12-25 | Glaxo Group Limited | Aminopiperidine derivatives |
| US7348434B2 (en) | 2003-08-08 | 2008-03-25 | Antony Bigot | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| FR2858619B1 (fr) * | 2003-08-08 | 2006-12-22 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2008249745B2 (en) * | 2007-05-09 | 2012-01-12 | Pfizer Inc. | Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR31753E (fr) * | 1925-12-03 | 1927-06-11 | Appareil photographique pour prise de vues, agrandissement et projection | |
| FR42781E (fr) * | 1932-05-23 | 1933-10-10 | Perfectionnements aux machines rotatives à capsuler les bouteilles | |
| FR959917A (es) * | 1946-06-25 | 1950-04-07 | ||
| FR2177511A1 (en) * | 1972-03-28 | 1973-11-09 | Omnium Chimique Sa | Quinolyl pipiridylethyl ketones - with vasodilatory and antispasmodic activity |
| FR2354771A1 (fr) * | 1976-06-18 | 1978-01-13 | Mar Pha Etu Expl Marques | ((quinolyl-4)-3 propyl-1) -4 piperidines, leur preparation et leur utilisation comme medicaments |
| PT66682B (pt) * | 1976-06-18 | 1978-11-15 | Ind Biolog Francaise | /(quinolyl-4)-propyl-1/-4 piperidines leur preparation et leur utilisation comme medicaments /(quinolyl-4)-propyl/-4 piperidines leur preparation et leur utilisation comme medicaments |
| FR2485014A1 (fr) * | 1980-06-20 | 1981-12-24 | Pharmindustrie | Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments |
-
1979
- 1979-12-21 FR FR7931396A patent/FR2471981A1/fr active Granted
-
1980
- 1980-12-02 US US06/212,293 patent/US4433150A/en not_active Expired - Lifetime
- 1980-12-12 DK DK530480A patent/DK530480A/da not_active Application Discontinuation
- 1980-12-12 EP EP80401788A patent/EP0031753B1/fr not_active Expired
- 1980-12-12 DE DE8080401788T patent/DE3069243D1/de not_active Expired
- 1980-12-15 AT AT0609680A patent/AT376670B/de not_active IP Right Cessation
- 1980-12-17 PT PT72212A patent/PT72212A/pt unknown
- 1980-12-19 CA CA000367172A patent/CA1178589A/fr not_active Expired
- 1980-12-19 ES ES498017A patent/ES498017A0/es active Granted
- 1980-12-19 NO NO803881A patent/NO155137C/no unknown
- 1980-12-19 JP JP18031480A patent/JPS5699476A/ja active Pending
- 1980-12-19 IE IE2684/80A patent/IE51124B1/en unknown
-
1981
- 1981-12-15 ES ES507998A patent/ES507998A0/es active Granted
- 1981-12-15 ES ES507997A patent/ES8207525A1/es not_active Expired
-
1982
- 1982-09-29 US US06/426,545 patent/US4505916A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES507997A0 (es) | 1982-10-01 |
| AT376670B (de) | 1984-12-27 |
| FR2471981A1 (fr) | 1981-06-26 |
| NO155137C (no) | 1987-02-18 |
| EP0031753B1 (fr) | 1984-09-19 |
| FR2471981B1 (es) | 1983-03-25 |
| ATA609680A (de) | 1984-05-15 |
| ES507998A0 (es) | 1982-10-01 |
| DK530480A (da) | 1981-06-22 |
| JPS5699476A (en) | 1981-08-10 |
| NO803881L (no) | 1981-06-22 |
| US4505916A (en) | 1985-03-19 |
| IE51124B1 (en) | 1986-10-15 |
| CA1178589A (fr) | 1984-11-27 |
| PT72212A (pt) | 1981-01-01 |
| NO155137B (no) | 1986-11-10 |
| ES8207525A1 (es) | 1982-10-01 |
| EP0031753A1 (fr) | 1981-07-08 |
| DE3069243D1 (en) | 1984-10-25 |
| ES8300745A1 (es) | 1982-11-01 |
| ES498017A0 (es) | 1982-11-01 |
| IE802684L (en) | 1981-06-21 |
| US4433150A (en) | 1984-02-21 |
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