Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
MSD KK
Original Assignee
Grelan Pharmaceutical Co Ltd
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd, Banyu Phamaceutical Co LtdfiledCriticalGrelan Pharmaceutical Co Ltd
Priority to ES508177ApriorityCriticalpatent/ES8300752A1/es
Publication of ES508177A0publicationCriticalpatent/ES508177A0/es
Publication of ES8300752A1publicationCriticalpatent/ES8300752A1/es
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE N-FTALIDIL-5-FLUOROURACILO, DE FORMULA (I), EN LA QUE R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN DERIVADO DE 5-FLUOROURACILO DE FORMULA (II) CON UN COMPUESTO 3-HALOGENOFTALIDILO DE FORMULA (III), EN LAS QUE R'' Y R'' SON HIDROGENO, ACILO, ETER CICLICO O FTALIDILO; R ES HIDROGENO, HALOGENO, ALCOXILO O ALCOHILO; Y X ES HALOGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, A TEMPERATURA NO SUPERIOR A LA AMBIENTE. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
ES508177A1981-12-211981-12-21"un procedimiento para la preparacion de derivados de n-ftalidil-5-fluorouracilo".
ExpiredES8300752A1
(es)