ES8301934A1 - Procedimiento para la obtencion de 6-(p-acilaminofeni)-5,5- dihidro-3(2h)-piridazinonas - Google Patents

Procedimiento para la obtencion de 6-(p-acilaminofeni)-5,5- dihidro-3(2h)-piridazinonas

Info

Publication number
ES8301934A1
ES8301934A1 ES503006A ES503006A ES8301934A1 ES 8301934 A1 ES8301934 A1 ES 8301934A1 ES 503006 A ES503006 A ES 503006A ES 503006 A ES503006 A ES 503006A ES 8301934 A1 ES8301934 A1 ES 8301934A1
Authority
ES
Spain
Prior art keywords
compounds
processes
preparation
dihydropyridazinones
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503006A
Other languages
English (en)
Other versions
ES503006A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES8301934A1 publication Critical patent/ES8301934A1/es
Publication of ES503006A0 publication Critical patent/ES503006A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 6-(P-ACILAMINOFENIL)-4,5-DIHIDRO-3(2H)-PIRIDAZINONAS, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALQUILO C <003> ; Y R PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN AGENTE DE ACILACION DE FORMULA R COY, EN LAS QUE R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), E Y ES HALOGENO, ALCOXI INFERIOR O EL RADICAL OCOR . LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA ENTRE 0<025>C Y 160<025>C. TAMBIEN SE PUEDEN OBTENER POR CICLIZACION DE UN COMPUESTO DE FORMULA (III), EN LA QUE R Y R SON LOS MISMOS QUE EN LA FORMULA (I), CON HIDRACINA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE AFECCIONES TROMBOEMBOLICAS Y ANTIHIPERTENSIVOS.
ES503006A 1980-06-13 1981-06-12 Procedimiento para la obtencion de 6-(p-acilaminofeni)-5,5- dihidro-3(2h)-piridazinonas Granted ES503006A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803022176 DE3022176A1 (de) 1980-06-13 1980-06-13 Neue dihydropyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel

Publications (2)

Publication Number Publication Date
ES8301934A1 true ES8301934A1 (es) 1983-01-16
ES503006A0 ES503006A0 (es) 1983-01-16

Family

ID=6104520

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503006A Granted ES503006A0 (es) 1980-06-13 1981-06-12 Procedimiento para la obtencion de 6-(p-acilaminofeni)-5,5- dihidro-3(2h)-piridazinonas

Country Status (12)

Country Link
US (1) US4410529A (es)
EP (1) EP0042107B1 (es)
JP (1) JPS5728058A (es)
AT (1) ATE12493T1 (es)
CA (1) CA1161437A (es)
DE (2) DE3022176A1 (es)
DK (1) DK148940C (es)
ES (1) ES503006A0 (es)
GR (1) GR74171B (es)
HU (2) HU184462B (es)
IE (1) IE51756B1 (es)
ZA (1) ZA813967B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209159A1 (de) * 1982-03-13 1983-09-15 Basf Ag, 6700 Ludwigshafen Neue 6-aryl-4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung
DE3328286A1 (de) * 1982-08-07 1984-02-09 Basf Ag, 6700 Ludwigshafen Neue anilide, verfahren zu ihrer herstellung und ihre verwendung
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
DE3302442A1 (de) * 1983-01-26 1984-07-26 Basf Ag, 6700 Ludwigshafen Neue pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung
JPWO2002036547A1 (ja) * 2000-11-01 2004-03-11 味の素株式会社 シクロプロパンカルボン酸アミド化合物及びその医薬用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670158U (de) 1953-11-05 1954-01-14 Gustav Fey Vorrichtung zur erfassung und verteilung von versand- und oder lagergut.
US3689652A (en) * 1970-10-09 1972-09-05 William Vincent Curran Method of lowering blood pressure in mammals
IL37788A0 (en) 1970-10-09 1971-12-29 American Cyanamid Co New pyridazinone compounds,their preparation and pharmaceutical compositions containing them
DE2123246C2 (de) 1971-05-11 1982-11-25 Basf Ag, 6700 Ludwigshafen 6-[p-(&beta;-Phenyläthylaminoacetylamino)-phenyl]-4,5-dihydropyridazon-(3)
US3824271A (en) * 1972-07-20 1974-07-16 American Cyanamid Co 3-alkyl-3-(benzoyl)propionitriles
US3888901A (en) * 1972-07-20 1975-06-10 American Cyanamid Co Process of preparing 3-alkyl-3-(benzoyl)propionitriles
DE2304977A1 (de) 1973-02-01 1974-08-08 Basf Ag Neue dihydropyridazinone
US4011321A (en) * 1973-12-19 1977-03-08 Smith Kline & French Laboratories Limited Pharmaceutical compositions and methods of inhibiting β-adrenergic receptors
DE2727481A1 (de) * 1977-06-18 1979-01-11 Basf Ag Dihydropyridazone und dihydropyridazone enthaltende therapeutische mittel

Also Published As

Publication number Publication date
ATE12493T1 (de) 1985-04-15
US4410529A (en) 1983-10-18
JPS5728058A (en) 1982-02-15
DK148940B (da) 1985-11-25
EP0042107B1 (de) 1985-04-03
EP0042107A1 (de) 1981-12-23
DE3169653D1 (en) 1985-05-09
GR74171B (es) 1984-06-07
CA1161437A (en) 1984-01-31
IE811286L (en) 1981-12-13
ES503006A0 (es) 1983-01-16
HU184460B (en) 1984-08-28
DK257381A (da) 1981-12-14
DE3022176A1 (de) 1982-01-07
HU184462B (en) 1984-08-28
IE51756B1 (en) 1987-03-18
ZA813967B (en) 1982-07-28
DK148940C (da) 1986-05-05

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401