ES8301963A1 - Un procedimiento para preparacion de nuevas piperidinoquinazolinas. - Google Patents
Un procedimiento para preparacion de nuevas piperidinoquinazolinas.Info
- Publication number
- ES8301963A1 ES8301963A1 ES499558A ES499558A ES8301963A1 ES 8301963 A1 ES8301963 A1 ES 8301963A1 ES 499558 A ES499558 A ES 499558A ES 499558 A ES499558 A ES 499558A ES 8301963 A1 ES8301963 A1 ES 8301963A1
- Authority
- ES
- Spain
- Prior art keywords
- carbons
- amino group
- piperidinoquinazolines
- preparation
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GYMTUXHRQWJXMW-UHFFFAOYSA-N 2-piperidin-1-ylquinazoline Chemical class C1CCCCN1C1=NC=C(C=CC=C2)C2=N1 GYMTUXHRQWJXMW-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- DMCSURRPVDKJIM-UHFFFAOYSA-N 6,7-dimethoxy-2-piperidin-1-ylquinazolin-4-amine Chemical class N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N1CCCCC1 DMCSURRPVDKJIM-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PIPERIDINOQUINAZOLINAS DE FORMULA (I), EN AL QUE R PUEDE SER UNO DE VARIOS RADICALES, Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE UN ALQUILO N-(2-CIANO-4,5-DIMETOXIFENILO)- ACILOPIPERIDINO-TIOFORMAMIDATO DE FORMULA (II), EN LA QUE R'' ES UN GRUPO ALQUILO INFERIOR Y R ES EL MISMO QUE EN LA FORMULA (I), CON AMONIACO, HALOGENURO AMONICO, UREA O HIDROALOGENURO DE UREA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE POLAR, TAL COMO FORMAMIDA, A TEMPERATURA ELEVADA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO DEPRESOR SOBRE LA TENSION SANGUINEA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI800481A FI800481A7 (fi) | 1980-02-19 | 1980-02-19 | Menetelmä substituoitujen asyylipiperiidiinien valmistamiseksi. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8301963A1 true ES8301963A1 (es) | 1982-12-16 |
| ES499558A0 ES499558A0 (es) | 1982-12-16 |
Family
ID=8513260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES499558A Granted ES499558A0 (es) | 1980-02-19 | 1981-02-18 | Un procedimiento para preparacion de nuevas piperidinoquinazolinas. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0034471A1 (es) |
| JP (1) | JPS56131578A (es) |
| AR (1) | AR228051A1 (es) |
| AU (1) | AU6739681A (es) |
| BG (1) | BG35041A3 (es) |
| DD (1) | DD158775A5 (es) |
| DK (1) | DK71681A (es) |
| ES (1) | ES499558A0 (es) |
| FI (1) | FI800481A7 (es) |
| GR (1) | GR66282B (es) |
| IL (1) | IL62113A0 (es) |
| IN (1) | IN152325B (es) |
| NO (1) | NO810548L (es) |
| NZ (1) | NZ196229A (es) |
| PL (1) | PL229760A1 (es) |
| PT (1) | PT72510B (es) |
| SU (1) | SU1042616A3 (es) |
| YU (1) | YU34181A (es) |
| ZA (1) | ZA81902B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES515338A0 (es) * | 1981-09-09 | 1983-11-01 | Orion Yhtymae Oy | "metodo para la preparacion de piperidinilquinazolidinas substituidas". |
| CA2077252C (en) | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
| BRPI0922010A2 (pt) * | 2008-11-14 | 2015-12-15 | Hoffmann La Roche | dervivados de quinazolina como antagonistas receptores de nk3 |
| TWI771327B (zh) * | 2016-10-05 | 2022-07-21 | 英商使命醫療公司 | 新穎化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2321890A1 (fr) * | 1975-08-26 | 1977-03-25 | Synthelabo | Nouveaux derives de la quinazoline, leurs sels, leur preparation et les medicaments qui en renferment |
-
1980
- 1980-02-19 FI FI800481A patent/FI800481A7/fi not_active Application Discontinuation
-
1981
- 1981-02-10 YU YU00341/81A patent/YU34181A/xx unknown
- 1981-02-10 NZ NZ196229A patent/NZ196229A/xx unknown
- 1981-02-11 IL IL62113A patent/IL62113A0/xx unknown
- 1981-02-11 ZA ZA00810902A patent/ZA81902B/xx unknown
- 1981-02-12 EP EP81300579A patent/EP0034471A1/en not_active Withdrawn
- 1981-02-16 PT PT72510A patent/PT72510B/pt unknown
- 1981-02-18 DK DK71681A patent/DK71681A/da not_active Application Discontinuation
- 1981-02-18 AU AU67396/81A patent/AU6739681A/en not_active Abandoned
- 1981-02-18 ES ES499558A patent/ES499558A0/es active Granted
- 1981-02-18 GR GR64174A patent/GR66282B/el unknown
- 1981-02-18 BG BG050877A patent/BG35041A3/xx unknown
- 1981-02-18 SU SU813250801A patent/SU1042616A3/ru active
- 1981-02-18 NO NO810548A patent/NO810548L/no unknown
- 1981-02-19 JP JP2231581A patent/JPS56131578A/ja active Pending
- 1981-02-19 PL PL22976081A patent/PL229760A1/xx unknown
- 1981-02-19 DD DD81227758A patent/DD158775A5/de unknown
- 1981-02-19 AR AR284351A patent/AR228051A1/es active
- 1981-02-20 IN IN198/CAL/81A patent/IN152325B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO810548L (no) | 1981-08-20 |
| ES499558A0 (es) | 1982-12-16 |
| GR66282B (es) | 1981-02-20 |
| NZ196229A (en) | 1983-02-15 |
| EP0034471A1 (en) | 1981-08-26 |
| PT72510B (en) | 1983-02-01 |
| AR228051A1 (es) | 1983-01-14 |
| PT72510A (en) | 1981-03-01 |
| PL229760A1 (es) | 1982-04-13 |
| FI800481A7 (fi) | 1981-01-01 |
| BG35041A3 (bg) | 1984-01-16 |
| IN152325B (es) | 1983-12-17 |
| DD158775A5 (de) | 1983-02-02 |
| JPS56131578A (en) | 1981-10-15 |
| YU34181A (en) | 1983-10-31 |
| DK71681A (da) | 1981-08-20 |
| SU1042616A3 (ru) | 1983-09-15 |
| AU6739681A (en) | 1981-08-27 |
| ZA81902B (en) | 1982-02-24 |
| IL62113A0 (en) | 1981-03-31 |
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