ES8302093A1 - Un procedimiento para obtener nuevos compuestos de beta-lac-tama - Google Patents

Un procedimiento para obtener nuevos compuestos de beta-lac-tama

Info

Publication number
ES8302093A1
ES8302093A1 ES505886A ES505886A ES8302093A1 ES 8302093 A1 ES8302093 A1 ES 8302093A1 ES 505886 A ES505886 A ES 505886A ES 505886 A ES505886 A ES 505886A ES 8302093 A1 ES8302093 A1 ES 8302093A1
Authority
ES
Spain
Prior art keywords
production
lactam compounds
medicines containing
novel beta
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505886A
Other languages
English (en)
Other versions
ES505886A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Ocean Co Ltd
Original Assignee
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55135829A external-priority patent/JPS5762280A/ja
Priority claimed from JP55144507A external-priority patent/JPS5770890A/ja
Priority claimed from JP55170864A external-priority patent/JPS5795987A/ja
Application filed by Sanraku Ocean Co Ltd filed Critical Sanraku Ocean Co Ltd
Publication of ES8302093A1 publication Critical patent/ES8302093A1/es
Publication of ES505886A0 publication Critical patent/ES505886A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE <021>-LACTAMA Y DE SUS SALES, DE FORMULA (I), EN LA QUE R ES HIDROGENO, HIDROXI O SULFONICO; Y R ES HIDROGENO O BENCILO, SUSTITUIDO O SIN SUSTITUIR. CONSISTE EN CULTIVAR EL MICROORGANISMO <004>STREPTOMYCES SP. OA-6129 (FERM BP11<005>, CAPAZ DE PRODUCIR UN COMPUESTO DE FORMULA (I), EN LA QUE R ES HIDROGENO Y R TIENE EL MISMO SIGNIFICADO ANTERIOR, EN UN MEDIO DE CULTIVO NUTRIENTE, EN CONDICIONES AEROBIAS, A UN PH ENTRE 4 Y 9 Y A UNA TEMPERATURA COMPRENDIDA ENTRE 20<025>C Y 40<025>C; SEGUIDO DE LA RECUPERACION DEL COMPUESTO OBTENIDO; Y, SI ES NECESARIO, TRANSFORMARLO EN SU ESTER BENCILICO O EN SU SAL. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIMICROBIANOS.
ES505886A 1980-10-01 1981-09-30 Un procedimiento para obtener nuevos compuestos de beta-lac-tama Granted ES505886A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP55135829A JPS5762280A (en) 1980-10-01 1980-10-01 Novel antibiotic oa-6129a and its preparation
JP55144507A JPS5770890A (en) 1980-10-17 1980-10-17 Novel antibiotic oa-6129b and its preparation
JP55170864A JPS5795987A (en) 1980-12-05 1980-12-05 Novel antibiotic oa-6129c and its preparation

Publications (2)

Publication Number Publication Date
ES8302093A1 true ES8302093A1 (es) 1983-01-01
ES505886A0 ES505886A0 (es) 1983-01-01

Family

ID=27317159

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505886A Granted ES505886A0 (es) 1980-10-01 1981-09-30 Un procedimiento para obtener nuevos compuestos de beta-lac-tama

Country Status (6)

Country Link
US (1) US4426390A (es)
EP (1) EP0048999B1 (es)
KR (1) KR850000577B1 (es)
CA (1) CA1182413A (es)
DE (1) DE3171598D1 (es)
ES (1) ES505886A0 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068485B1 (en) * 1981-07-01 1987-11-11 Sanraku Incorporated Novel antibiotics and process for production thereof
JPS5857392A (ja) * 1981-10-02 1983-04-05 Sanraku Inc 新規な抗生物質ｏａ−６１２９のリン酸エステル
KR840003255A (ko) * 1982-01-28 1984-08-20 스즈끼 시즈오 항생물질 oa-6129a,b1,b2의 유도체 및 그 제법
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
CH632508A5 (de) * 1975-11-21 1982-10-15 Merck & Co Inc Verfahren zur herstellung von neuen estern des n-acylierten thienamycins.
US4387051A (en) * 1979-10-29 1983-06-07 Beecham Group Limited β-Lactam antibiotics, their preparation and their use in pharmaceutical compositions

Also Published As

Publication number Publication date
EP0048999B1 (en) 1985-07-31
EP0048999A1 (en) 1982-04-07
DE3171598D1 (en) 1985-09-05
CA1182413A (en) 1985-02-12
KR850000577B1 (ko) 1985-04-29
ES505886A0 (es) 1983-01-01
US4426390A (en) 1984-01-17
KR830007840A (ko) 1983-11-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603