ES8303528A1 - Un procedimiento para la preparacion de nuevos derivados de los compuestos c-076 - Google Patents

Un procedimiento para la preparacion de nuevos derivados de los compuestos c-076

Info

Publication number
ES8303528A1
ES8303528A1 ES511953A ES511953A ES8303528A1 ES 8303528 A1 ES8303528 A1 ES 8303528A1 ES 511953 A ES511953 A ES 511953A ES 511953 A ES511953 A ES 511953A ES 8303528 A1 ES8303528 A1 ES 8303528A1
Authority
ES
Spain
Prior art keywords
compounds
incubation
derivatives
microsomic
hydroximethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES511953A
Other languages
English (en)
Other versions
ES511953A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8303528A1 publication Critical patent/ES8303528A1/es
Publication of ES511953A0 publication Critical patent/ES511953A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LOS COMPUESTOS C-076 DE FORMULA (I) EN LA QUE R Y R PUEDEN SER VARIOS RADICALES Y LA LINEA DISCONTINUA EN 22-23 REPRESENTA ENLACE DOBLE O SENCILLO. CONSISTE EN LA INCUBACION CON PROTEINA MICROSOMICA DE HIGADO UN SUBSTRATO DEL COMPUESTO CORRESPONDIENTE EN EL QUE EL GRUPO DE LA POSICION 24 ES METILO EN VEZ DE HIDROXIMETILO. LA INCUBACION SE LLEVA A CABO EN UNA MEZCLA DE DISOLVENTES, ACUOSOS O ALCOHOLICOS, AGENTES TAMPONANTES A BASE DE FOSFATOS Y AGENTES FORTIFICANTES. ESTOS COMPUESTOS TIENEN APLICACIONES COMO ANTIPARASITARIOS Y ANTIHELMINTICOS, EN SANIDAD HUMANA Y ANIMAL Y EN AGRICULTURA.
ES511953A 1981-05-11 1982-05-05 Un procedimiento para la preparacion de nuevos derivados de los compuestos c-076 Granted ES511953A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/262,082 US4333925A (en) 1981-05-11 1981-05-11 Derivatives of C-076 compounds

Publications (2)

Publication Number Publication Date
ES8303528A1 true ES8303528A1 (es) 1983-02-01
ES511953A0 ES511953A0 (es) 1983-02-01

Family

ID=22996082

Family Applications (1)

Application Number Title Priority Date Filing Date
ES511953A Granted ES511953A0 (es) 1981-05-11 1982-05-05 Un procedimiento para la preparacion de nuevos derivados de los compuestos c-076

Country Status (12)

Country Link
US (1) US4333925A (es)
EP (1) EP0065403B1 (es)
JP (1) JPS57206695A (es)
AT (1) ATE14883T1 (es)
AU (1) AU550391B2 (es)
DE (1) DE3265386D1 (es)
DK (1) DK208382A (es)
ES (1) ES511953A0 (es)
GR (1) GR75502B (es)
NZ (1) NZ200497A (es)
PT (1) PT74846B (es)
ZA (1) ZA823196B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510133A (en) * 1982-04-22 1985-04-09 Imperial Chemical Industries Plc Method for combating pests
US4560677A (en) * 1984-01-31 1985-12-24 Merck & Co., Inc. Synergistic avermectin combination for treating plant pests
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
US4668696A (en) * 1985-07-29 1987-05-26 Merck & Co., Inc. Novel averonectin fermentation product of a microorganism with anthelmintic activity
NZ216908A (en) * 1985-07-29 1989-06-28 Merck & Co Inc Avermectin derivatives
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
DE3727648A1 (de) * 1987-08-19 1989-03-02 Bayer Ag Neue avermectin derivate, verfahren zu ihrer herstellung und ihre verwendung
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ATE87926T1 (de) * 1987-11-09 1993-04-15 Pfizer Ethylierte avermectine.
US4963667A (en) * 1987-11-10 1990-10-16 Merck & Co., Inc. Ivermectin derivative compounds and process for preparing the same
GB8726730D0 (en) 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
US5008250A (en) * 1988-05-25 1991-04-16 Merck & Co., Inc. Avermectins with a cleaved furan ring and an 8a hydroxy group
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
US5189026A (en) * 1991-06-07 1993-02-23 Fractal Laboratories, Inc. Treatment of human diseases involving dysregulation or dysfunction of the nervous system
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US5248678A (en) * 1992-06-30 1993-09-28 Fractal Laboratories, Inc. Methods for increasing arousal and alertness and for the amelioration of comatose states
US6265571B1 (en) 1999-07-12 2001-07-24 Magellan Laboratories, Inc. Purification process for anti-parasitic fermentation product
AU2006313007C1 (en) * 2005-11-10 2019-10-03 Elanco Australasia Pty Limited Method of treating parasites
US8901163B2 (en) 2007-01-03 2014-12-02 Galderma S.A. Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
US8901090B2 (en) 2010-10-20 2014-12-02 Galderma S.A. Method of treating otitis externa using macrocyclic lactone compound
US8912151B2 (en) 2010-10-20 2014-12-16 Galderma S.A. Method of treating hemorrhoids using macrocyclic lactone compound
WO2012100835A1 (en) 2011-01-28 2012-08-02 Laboratorios Del Dr. Esteve, S.A. Methods and compositions for the treatment of aids
CN104402953B (zh) * 2014-11-28 2017-07-28 大庆志飞生物化工有限公司 阿维菌素单糖化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4285963A (en) * 1980-08-07 1981-08-25 Merck & Co., Inc. Novel derivatives of C-076 compounds

Also Published As

Publication number Publication date
DK208382A (da) 1982-11-12
ZA823196B (en) 1983-03-30
JPS57206695A (en) 1982-12-18
GR75502B (es) 1984-07-24
EP0065403A1 (en) 1982-11-24
AU8329982A (en) 1982-11-18
PT74846A (en) 1982-06-01
AU550391B2 (en) 1986-03-20
ES511953A0 (es) 1983-02-01
DE3265386D1 (en) 1985-09-19
NZ200497A (en) 1985-11-08
ATE14883T1 (de) 1985-08-15
US4333925A (en) 1982-06-08
EP0065403B1 (en) 1985-08-14
PT74846B (en) 1985-06-28

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