ES8304947A1 - "procedimiento para la preparacion de pirimidin-2-sulfuros y sus s-oxidos". - Google Patents

"procedimiento para la preparacion de pirimidin-2-sulfuros y sus s-oxidos".

Info

Publication number
ES8304947A1
ES8304947A1 ES508498A ES508498A ES8304947A1 ES 8304947 A1 ES8304947 A1 ES 8304947A1 ES 508498 A ES508498 A ES 508498A ES 508498 A ES508498 A ES 508498A ES 8304947 A1 ES8304947 A1 ES 8304947A1
Authority
ES
Spain
Prior art keywords
group
compounds
carboxyl
esterified
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508498A
Other languages
English (en)
Other versions
ES508498A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nyegaard and Co AS
Original Assignee
Nyegaard and Co AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard and Co AS filed Critical Nyegaard and Co AS
Publication of ES508498A0 publication Critical patent/ES508498A0/es
Publication of ES8304947A1 publication Critical patent/ES8304947A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C07D239/40—One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PIRIMIDIN-2-SULFUROS Y SUS S-OXIDOS Y DE SUS SALES, DE FORMULA (I), EN LA QUE X ES FLUOR, CLORO O BROMO; Y R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN ACIDO SULFINICO DE FORMULA R SO H, EN LAS QUE X, R , R 2 Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION DE SUSTITUCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA INHIBIR LA PROLIFERACION DE CELULAS ANORMALES.
ES508498A 1980-01-10 1982-01-02 "procedimiento para la preparacion de pirimidin-2-sulfuros y sus s-oxidos". Expired ES8304947A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8000802 1980-01-10

Publications (2)

Publication Number Publication Date
ES508498A0 ES508498A0 (es) 1983-03-16
ES8304947A1 true ES8304947A1 (es) 1983-03-16

Family

ID=10510550

Family Applications (2)

Application Number Title Priority Date Filing Date
ES498406A Expired ES8205782A1 (es) 1980-01-10 1981-01-09 Procedimiento para la preparacion de pirimidin-2-sulfuros y sus s-oxidos
ES508498A Expired ES8304947A1 (es) 1980-01-10 1982-01-02 "procedimiento para la preparacion de pirimidin-2-sulfuros y sus s-oxidos".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES498406A Expired ES8205782A1 (es) 1980-01-10 1981-01-09 Procedimiento para la preparacion de pirimidin-2-sulfuros y sus s-oxidos

Country Status (12)

Country Link
US (1) US4423047A (es)
EP (1) EP0033195B1 (es)
JP (1) JPS56154467A (es)
AT (1) ATE16799T1 (es)
AU (1) AU549117B2 (es)
CA (1) CA1168240A (es)
DE (1) DE3173080D1 (es)
DK (1) DK149885B (es)
ES (2) ES8205782A1 (es)
NO (1) NO810064L (es)
NZ (1) NZ195992A (es)
ZA (1) ZA81140B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57136575A (en) * 1981-01-09 1982-08-23 Nyegaard & Co As Substituted pyrimidine-2-one compound
NO161440C (no) * 1982-02-24 1989-08-16 Nyegaard & Co As Analogifremgangsmaate for fremstilling av fysiologisk aktive pyrimidin-2-oner.
JPH0739394B2 (ja) * 1985-05-30 1995-05-01 住友化学工業株式会社 含窒素複素環化合物およびそれを有効成分として含有する有害生物防除剤
JPS63179840A (ja) * 1986-07-24 1988-07-23 Yamanouchi Pharmaceut Co Ltd 新規化学物質
US4808591A (en) * 1988-02-16 1989-02-28 Pfizer Inc. Antiulcer 8-(2-pyrimidylsulfinyl)quinolines
DE3912155A1 (de) * 1988-09-24 1990-03-29 Bayer Ag Schaedlingsbekaempfungsmittel auf basis von 2-halogenalkylthio-substituierten pyrimidin-derivaten
WO1991016309A1 (en) * 1990-04-12 1991-10-31 University Of Georgia Research Foundation, Inc. Synthetic piperidinediones with cytostatic activity
GB9205484D0 (en) * 1991-03-28 1992-04-29 Ici Plc Heterocyclic compounds
GB9205487D0 (en) * 1991-03-28 1992-04-29 Ici Plc Heterocyclic compounds
GB9106609D0 (en) * 1991-03-28 1991-05-15 Ici Plc Heterocyclic compounds
GB9219635D0 (en) * 1992-09-16 1992-10-28 Ici Plc Heterocyclic compounds
DE19622270A1 (de) * 1996-06-03 1997-12-04 Basf Ag Pyrimidin-4-carbonsäureamide
US6268310B1 (en) * 1997-01-28 2001-07-31 Nippon Soda Co., Ltd. Oxazole derivative, process for producing the same, and herbicide
KR100818845B1 (ko) 1998-09-09 2008-04-01 메타베이시스 테라퓨틱스, 인크. 신규한 프럭토스 1,6-비스포스파타제의 헤테로방향족 억제제
JP2003506312A (ja) * 1998-11-30 2003-02-18 石原産業株式会社 メタ−ニトロフェノール誘導体およびその製造法
US6313072B1 (en) * 1999-02-18 2001-11-06 American Cyanamid Company Herbicidal 2-aryloxy-or 2-arylthio-6-arylpyrimidines
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US7138404B2 (en) * 2001-05-23 2006-11-21 Hoffmann-La Roche Inc. 4-aminopyrimidine derivatives
DE10154075A1 (de) * 2001-11-02 2003-05-15 Bayer Cropscience Ag Substituierte Pyrimidine
CA2657247A1 (en) * 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
US9364191B2 (en) 2013-02-11 2016-06-14 University Of Rochester Method and apparatus of spectral differential phase-contrast cone-beam CT and hybrid cone-beam CT
CA2934891C (en) 2014-01-16 2023-02-28 Nicholas Ryan DEPREZ Pyrimidinyloxy benzene derivatives as herbicides
TWI713530B (zh) 2015-06-05 2020-12-21 美商艾佛艾姆希公司 作為除草劑之嘧啶氧基苯衍生物
GB201514649D0 (en) * 2015-08-18 2015-09-30 Medical Res Council 2-Sulfonylpyrimidines
CN110785413B (zh) 2017-05-02 2024-08-02 Fmc公司 作为除草剂的嘧啶氧基苯并稠合化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112316A (en) * 1963-11-26 Z-o-chlohobenzylmercapto-x-dimethyl-
US2876224A (en) * 1957-08-07 1959-03-03 American Home Prod Basic esters of substituted pyrimidine-4-carboxylic acids and their preparation
DE2455582A1 (de) 1974-11-23 1976-05-26 Hoechst Ag Verfahren zur herstellung von (1-alkyl-5-nitro-imidazolyl-2-alkyl)heteroaryl-sulfiden
GB1561290A (en) 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
US4248618A (en) * 1977-05-06 1981-02-03 Ici Australia Limited Derivatives of (pyrimidyloxy)phenoxy-alkanecarboxylic acid and herbicidal compositions thereof
NZ188244A (en) * 1977-09-13 1981-04-24 Ici Australia Ltd 2-substituted pyrimidines compositions growth regulating processes

Also Published As

Publication number Publication date
ES508498A0 (es) 1983-03-16
ES498406A0 (es) 1982-08-01
NO810064L (no) 1981-07-13
DK8081A (da) 1981-07-11
NZ195992A (en) 1983-11-30
AU549117B2 (en) 1986-01-16
EP0033195B1 (en) 1985-12-04
CA1168240A (en) 1984-05-29
ES8205782A1 (es) 1982-08-01
EP0033195A1 (en) 1981-08-05
JPS56154467A (en) 1981-11-30
DK149885B (da) 1986-10-20
DE3173080D1 (en) 1986-01-16
ZA81140B (en) 1982-02-24
US4423047A (en) 1983-12-27
ATE16799T1 (de) 1985-12-15
AU6613081A (en) 1981-07-16

Similar Documents

Publication Publication Date Title
DE3173080D1 (en) Pyrimidine-2-sulphides and their s-oxides for use in medicine, pharmaceutical compositions containing them, processes for their preparation and such compounds when novel per se
IL68075A0 (en) Pyridine and pyrane derivatives,their preparation and pharmaceutical compositions containing them
FR2307528B1 (es)
HK41086A (en) Amine salts of clavulanic acid, methods for their preparation and compositions containing them
ES8306753A1 (es) "procedimiento para la preparacion de nuevos derivados de azepina".
ES8300768A1 (es) "procedimiento para la preparacion de nuevas pirimido (5,4-d) pirimidinas trisustituidas".
ZA912618B (en) 3-aminochroman derivatives,process for preparing these and pharmaceutical compositions containing them
ES481551A1 (es) Procedimiento de preparacion de nuevos compuestos bis (ari- loxicarboxilicos).
ES8308860A1 (es) "un procedimiento para la preparacion de pirimid-2-onas".
ES483247A1 (es) Procedimiento para la obtencion de nuevos diazacicloalquenostiosustituidos
ES8200648A2 (es) Procedimiento de preparacion de compuestos opacificantes para radiografia y similares
ES8406442A1 (es) Un procedimiento para preparar compuestos de acido quinolilacetico
ES451209A1 (es) Procedimiento de fabricacion de sulfoximidas sustituidas y sus sales medicamentosas.
ES8401059A1 (es) Procedimiento para la preparacion de fenoleteres biciclicos.
ES463797A1 (es) Procedimiento para la preparacion de o-(2-hidroxipropil)- aldoximas sustituidas con radicales basicos
ES8104242A1 (es) Un procedimiento para la preparacion de nuevos derivados de hidantoina.
ES481210A1 (es) Un procedimiento para preparar benzoxepinas.
ES8600318A1 (es) Procedimiento para la obtencion de esteres de acido fosfonico
IL74877A0 (en) 9-halogen prostaglandin derivatives,process for the preparation thereof and pharmaceutical compositions containing the same