ES8305300A1 - Procedimiento para la obtencion de monoesteres de acido fumarico. - Google Patents

Procedimiento para la obtencion de monoesteres de acido fumarico.

Info

Publication number
ES8305300A1
ES8305300A1 ES513861A ES513861A ES8305300A1 ES 8305300 A1 ES8305300 A1 ES 8305300A1 ES 513861 A ES513861 A ES 513861A ES 513861 A ES513861 A ES 513861A ES 8305300 A1 ES8305300 A1 ES 8305300A1
Authority
ES
Spain
Prior art keywords
fumaric acid
monoesters
preparation
acid monoesters
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513861A
Other languages
English (en)
Other versions
ES513861A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES513861A0 publication Critical patent/ES513861A0/es
Publication of ES8305300A1 publication Critical patent/ES8305300A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyethers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE MONOESTERES DE ACIDO FUMARICO. CONSISTE EN LA REACCION DE UN COMPUESTO DE HIDROXI, TAL COMO UN ALCOHOL ALIFATICO, CON ANHIDRIDO DE ACIDO MALEICO, EN CASO NECESARIO SUSTITUIDO, EN DISOLUCION EN UN DISOLVENTE INERTE O EN ESTADO FUNDIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 100 C Y 220 C, EN PRESENCIA DE UN CATALIZADOR CIS-TRANS, TAL COMO HALOGENO, UN ACIDO O SU SAL AMONICA. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS PARA LA OBTENCION DE MATERIALES SINTETICOS DEL TIPO POLIHIDANTOINA.
ES513861A 1981-07-11 1982-07-09 Procedimiento para la obtencion de monoesteres de acido fumarico. Expired ES8305300A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813127432 DE3127432A1 (de) 1981-07-11 1981-07-11 Verfahren zur herstellung von fumarsaeuremonoester

Publications (2)

Publication Number Publication Date
ES513861A0 ES513861A0 (es) 1983-04-01
ES8305300A1 true ES8305300A1 (es) 1983-04-01

Family

ID=6136683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513861A Expired ES8305300A1 (es) 1981-07-11 1982-07-09 Procedimiento para la obtencion de monoesteres de acido fumarico.

Country Status (5)

Country Link
US (1) US4515974A (es)
EP (1) EP0069926B1 (es)
JP (1) JPS5818335A (es)
DE (2) DE3127432A1 (es)
ES (1) ES8305300A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956492A (en) * 1984-03-14 1990-09-11 Exxon Research And Engineering Co. Dialkyl fumarate - vinyl acetate copolymers useful as dewaxing aids
DE3619804A1 (de) * 1986-06-12 1987-12-17 Henkel Kgaa Dicarbonsaeuremono-(2-hydroxydodecyl)ester, deren salze und deren verwendung als korrosionsinhibitor in waessrigen systemen
JPH0749396B2 (ja) * 1987-09-04 1995-05-31 雪印乳業株式会社 新規アルプレノロール誘導体
US5214198A (en) * 1991-12-20 1993-05-25 American Cyanamid Company Process for the manufacture of halomaleic and halofumaric esters
US5506289A (en) * 1993-07-23 1996-04-09 Gen Electric Liquid injection molding inhibitors for curable compositions
US5674966A (en) * 1995-06-05 1997-10-07 General Electric Company Low molecular weight liquid injection molding resins having a high vinyl content
FR2736060B1 (fr) * 1995-06-30 1998-10-23 Gen Electric Compositions a base de silicone elastomere, durcissables par la chaleur, et articles obtenus a partir de ces compositions
US5721202A (en) * 1995-11-03 1998-02-24 The Procter & Gamble Company Perfumes for laundry and cleaning composition
US5562847A (en) * 1995-11-03 1996-10-08 The Procter & Gamble Company Dryer-activated fabric conditioning and antistatic compositions with improved perfume longevity
DE19814358C2 (de) * 1998-03-31 2002-01-17 Fumapharm Ag Muri Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn
DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
DE10000577A1 (de) 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
AU2002219236B2 (en) * 2001-01-12 2006-02-09 Biogen International Gmbh Fumaric acid amides
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
WO2005023241A1 (en) * 2003-09-09 2005-03-17 Fumapharm Ag The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
EP1930338A1 (en) 2006-12-01 2008-06-11 E-brain Corporation Ltd. Fumaric acid derivates and ophtalmic lenses using the same
DK2653873T3 (da) 2007-02-08 2022-07-25 Biogen Ma Inc Sammensætninger og anvendelser til behandling af multipel sklerose
PT2139467T (pt) * 2007-02-08 2016-12-16 Biogen Ma Inc Neuroproteção em doenças desmielinizantes
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
CN105452213B (zh) 2013-03-14 2017-09-22 阿尔克梅斯制药爱尔兰有限公司 富马酸酯前体药物及其在治疗多种疾病中的应用
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10626076B2 (en) * 2014-03-17 2020-04-21 Biophore India Pharmaeuticals Pvt. Ltd. Process for the synthesis of dimethyl fumarate
US10213411B2 (en) 2015-08-27 2019-02-26 Vijaykumar Rajasekhar Use of prodrugs of fumarates in treating heart failure diseases
US10463642B2 (en) 2016-02-01 2019-11-05 Vijaykumar Rajasekhar Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate
CN117486717A (zh) * 2023-11-20 2024-02-02 常州吉恩药业有限公司 一种硬脂富马酸钠的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2254382A (en) * 1938-10-03 1941-09-02 Rohm & Haas Polymerizable mono-esters of maleic acid and polymers derived therefrom
US2764609A (en) * 1953-07-24 1956-09-25 Monsanto Chemicals Isomerization of dialkyl maleates to dialkyl fumarates
DE1165586B (de) * 1961-07-13 1964-03-19 Dr Walter Schliesser Verfahren zur Herstellung von Fumarsaeuremonoalkylestern durch Isomerisieren von Maleinsaeurehalbestern
US3378470A (en) * 1965-05-17 1968-04-16 John S Guleserian Electrodeposition of nickel
US3475483A (en) * 1966-02-23 1969-10-28 Ppg Industries Inc Isomerization of maleates with alkyl chlorocarbonate
GB1143115A (en) * 1966-05-10 1969-02-19 Pfizer & Co C Isomerization of molten monoalkyl maleates to monoalkyl fumarates

Also Published As

Publication number Publication date
JPS5818335A (ja) 1983-02-02
EP0069926B1 (de) 1985-09-25
DE3127432A1 (de) 1983-02-03
DE3266545D1 (en) 1985-10-31
EP0069926A1 (de) 1983-01-19
US4515974A (en) 1985-05-07
ES513861A0 (es) 1983-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991007