ES8306151A1 - Procedimiento para preparar derivados de purina. - Google Patents
Procedimiento para preparar derivados de purina.Info
- Publication number
- ES8306151A1 ES8306151A1 ES507102A ES507102A ES8306151A1 ES 8306151 A1 ES8306151 A1 ES 8306151A1 ES 507102 A ES507102 A ES 507102A ES 507102 A ES507102 A ES 507102A ES 8306151 A1 ES8306151 A1 ES 8306151A1
- Authority
- ES
- Spain
- Prior art keywords
- purine derivatives
- production
- hydrogen
- intermediates therefor
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 150000003212 purines Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- VAEPQHITLRNBPM-UHFFFAOYSA-N 9-[(2-chloro-6-fluorophenyl)methyl]-n-methylpurin-6-amine Chemical compound C1=NC=2C(NC)=NC=NC=2N1CC1=C(F)C=CC=C1Cl VAEPQHITLRNBPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Chemical group 0.000 abstract 1
- 229940124536 anticoccidial agent Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003224 coccidiostatic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PURINA, DE FORMULA GENERAL (I), EN LA QUE R Y R SON, CADA UNO DE ELLOS, HALOGENO; Y R ES ALCOHILO O ALILO, Y SUS SALES DE ADICION DE ACIDOS. COMPRENDE LAS SIGUIENTES FASES: PRIMERA, SE SOMETE A UNA REACCION DE REDUCCION UN COMPUESTO DE ARILAZOPIRIMIDINA DE FORMULA GENERAL (I), EN LA QUE R ES ARILO; Y R TIENE EL SIGNIFICADO YA INDICADO; SEGUNDA, EL PRODUCTO RESULTANTE SE HACE REACCIONAR CON ACIDO FORMICO EN PRESENCIA DE UN DERIVADO DEL ACIDO CARBOXILICO; Y POR ULTIMO, EL PRODUCTO RESULTANTE DE LA SEGUNDA FASE SE HACE REACCIONAR CON UN COMPUESTO DE FORMULA (III), EN LA QUE R Y R TIENEN EL SIGNIFICADO YA INDICADO; Y X ES HALOGENO, EN PRESENCIA DE UNA BASE. DE APLICACION COMO AGENTES CONTRA LOS COCCIDIOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55161099A JPS5785388A (en) | 1980-11-14 | 1980-11-14 | Preparation of purine derivative |
| JP12951881A JPS5832867A (ja) | 1981-08-18 | 1981-08-18 | 新規アリ−ルアゾピリミジン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES507102A0 ES507102A0 (es) | 1983-05-01 |
| ES8306151A1 true ES8306151A1 (es) | 1983-05-01 |
Family
ID=26464872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507102A Expired ES8306151A1 (es) | 1980-11-14 | 1981-11-13 | Procedimiento para preparar derivados de purina. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4423219A (es) |
| EP (1) | EP0052959B1 (es) |
| BR (1) | BR8107358A (es) |
| CA (1) | CA1171081A (es) |
| DE (1) | DE3173671D1 (es) |
| DK (1) | DK503081A (es) |
| ES (1) | ES8306151A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR029347A1 (es) * | 1999-04-02 | 2003-06-25 | Euro Celtique Sa | Compuesto de adenina, compuesto de isognanina y 2,6-ditioxantina como precursor del mismo, uso de dichos compuestos para preparar una composicion farmaceutica y dicha composicion farmaceutica |
| CN103992322A (zh) * | 2014-05-20 | 2014-08-20 | 安徽农业大学 | 一种抗球虫药物氟腺嘌呤的合成方法 |
| CN107698589B (zh) * | 2017-10-16 | 2019-06-07 | 浙江金伯士药业有限公司 | 一种阿德呋啉的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794270A (fr) * | 1972-01-21 | 1973-07-19 | Basf Ag | Pigments organosolubles derives de la pyrimidine |
| US4092314A (en) * | 1975-07-07 | 1978-05-30 | Merck & Co., Inc. | Preparation of 4,6-diamino-5-arylazopyrimidines and adenine compounds |
| DE2715984A1 (de) * | 1977-04-09 | 1978-10-26 | Basf Ag | Farbstoffzubereitungen fuer cellulose und cellulosehaltiges textilmaterial |
| US4189485A (en) * | 1977-08-23 | 1980-02-19 | Takeda Chemical Industries, Ltd. | Purine derivatives |
-
1981
- 1981-10-30 EP EP81305192A patent/EP0052959B1/en not_active Expired
- 1981-10-30 DE DE8181305192T patent/DE3173671D1/de not_active Expired
- 1981-11-04 US US06/318,277 patent/US4423219A/en not_active Expired - Lifetime
- 1981-11-12 BR BR8107358A patent/BR8107358A/pt unknown
- 1981-11-13 CA CA000389997A patent/CA1171081A/en not_active Expired
- 1981-11-13 DK DK503081A patent/DK503081A/da not_active Application Discontinuation
- 1981-11-13 ES ES507102A patent/ES8306151A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1171081A (en) | 1984-07-17 |
| BR8107358A (pt) | 1982-08-03 |
| EP0052959A1 (en) | 1982-06-02 |
| US4423219A (en) | 1983-12-27 |
| ES507102A0 (es) | 1983-05-01 |
| DK503081A (da) | 1982-05-15 |
| EP0052959B1 (en) | 1986-01-29 |
| DE3173671D1 (en) | 1986-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971201 |