ES471356A1 - Procedimiento de obtencion de r,s-2,3,5,6-tetrahidro-6-fenil-imidazo (2,1-b)-tiazole (tetramisole) - Google Patents
Procedimiento de obtencion de r,s-2,3,5,6-tetrahidro-6-fenil-imidazo (2,1-b)-tiazole (tetramisole)Info
- Publication number
- ES471356A1 ES471356A1 ES471356A ES471356A ES471356A1 ES 471356 A1 ES471356 A1 ES 471356A1 ES 471356 A ES471356 A ES 471356A ES 471356 A ES471356 A ES 471356A ES 471356 A1 ES471356 A1 ES 471356A1
- Authority
- ES
- Spain
- Prior art keywords
- tetramisole
- reaction
- denoting
- image
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 title abstract 2
- 229960001614 levamisole Drugs 0.000 title abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006210 cyclodehydration reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento de obtención de R, S-2,3,5,6-tetrahidro -6-fenil-imidazo (2,1-b) tiazole (tetramisole). Lo que pretende este invento es un proceso nuevo de síntesis de Tetramisol, fácil de realizar tecnológicamente y apropiado para la producción industrial, empleando materias primas mas accesibles, principalmente R,S-alfa-(2-hidroxietilaminometil)-benzilamina (IV), obtenida de productos básicos de la síntesis orgánica. El proceso de obtener R,S-2,3,5,6-tetrahidro-6-genil-imidazo-(2,1b)-tiazol (I) se realiza de acuerdo con este invento, interaccionando R,S-alfa-(2-hidroxietilaminometil)-benzilamina (Fórmula IV). El nombre del compuesto IV está formado de acuerdo con las disposiciones de la nomenclatura adoptadas por los convenios químicos. Este compuesto puede llamarse también R,S-2-(2-hidroxietilamino)-1-fenil-etilamina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG3790777 | 1977-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES471356A1 true ES471356A1 (es) | 1979-09-16 |
Family
ID=3904004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471356A Expired ES471356A1 (es) | 1977-07-06 | 1978-07-03 | Procedimiento de obtencion de r,s-2,3,5,6-tetrahidro-6-fenil-imidazo (2,1-b)-tiazole (tetramisole) |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5414997A (es) |
| BE (1) | BE868744A (es) |
| CA (1) | CA1100508A (es) |
| DE (1) | DE2829822A1 (es) |
| ES (1) | ES471356A1 (es) |
| FR (1) | FR2396761A1 (es) |
| GB (1) | GB2002350B (es) |
| HU (1) | HU181927B (es) |
| IT (1) | IT1174324B (es) |
| NL (1) | NL7807266A (es) |
| SU (1) | SU922107A1 (es) |
| YU (1) | YU162278A (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5330897U (es) * | 1976-08-24 | 1978-03-16 | ||
| EP0010851B1 (en) * | 1978-11-06 | 1982-08-04 | American Cyanamid Company | Process for the preparation of tetramisole |
| CA1135270A (en) * | 1978-11-06 | 1982-11-09 | American Cyanamid Company | Processes for the preparation of tetramisole and novel intermediates |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3726894A (en) * | 1971-06-24 | 1973-04-10 | American Cyanamid Co | The compound 1-(2-hydroxyethyl)-4-phenyl-2-imidazolidinethione |
| US3865836A (en) * | 1972-12-08 | 1975-02-11 | Janssen Pharmaceutica Nv | Bicyclic imidazoles |
-
1978
- 1978-06-29 HU HU78PA1322A patent/HU181927B/hu unknown
- 1978-07-03 ES ES471356A patent/ES471356A1/es not_active Expired
- 1978-07-05 NL NL7807266A patent/NL7807266A/xx not_active Application Discontinuation
- 1978-07-05 SU SU787770240A patent/SU922107A1/ru active
- 1978-07-05 BE BE2057119A patent/BE868744A/xx not_active IP Right Cessation
- 1978-07-05 IT IT50170/78A patent/IT1174324B/it active
- 1978-07-05 CA CA306,851A patent/CA1100508A/en not_active Expired
- 1978-07-05 JP JP8247278A patent/JPS5414997A/ja active Pending
- 1978-07-06 DE DE19782829822 patent/DE2829822A1/de not_active Ceased
- 1978-07-06 YU YU01622/78A patent/YU162278A/xx unknown
- 1978-07-06 FR FR7820188A patent/FR2396761A1/fr active Granted
- 1978-07-06 GB GB7829071A patent/GB2002350B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2396761A1 (fr) | 1979-02-02 |
| CA1100508A (en) | 1981-05-05 |
| NL7807266A (nl) | 1979-01-09 |
| YU162278A (en) | 1982-08-31 |
| JPS5414997A (en) | 1979-02-03 |
| SU922107A1 (ru) | 1982-04-23 |
| HU181927B (en) | 1983-11-28 |
| FR2396761B1 (es) | 1981-12-18 |
| IT1174324B (it) | 1987-07-01 |
| GB2002350B (en) | 1982-02-10 |
| DE2829822A1 (de) | 1979-02-01 |
| GB2002350A (en) | 1979-02-21 |
| BE868744A (fr) | 1978-11-03 |
| IT7850170A0 (it) | 1978-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000201 |