ES8306594A1 - Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells - Google Patents
Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cellsInfo
- Publication number
- ES8306594A1 ES8306594A1 ES512691A ES512691A ES8306594A1 ES 8306594 A1 ES8306594 A1 ES 8306594A1 ES 512691 A ES512691 A ES 512691A ES 512691 A ES512691 A ES 512691A ES 8306594 A1 ES8306594 A1 ES 8306594A1
- Authority
- ES
- Spain
- Prior art keywords
- phenol
- vaccine
- esp
- contg
- humans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960005486 vaccine Drugs 0.000 title abstract 5
- 241000589567 Brucella abortus Species 0.000 title abstract 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title abstract 3
- 206010006500 Brucellosis Diseases 0.000 title abstract 2
- 229940056450 brucella abortus Drugs 0.000 title abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 241001148106 Brucella melitensis Species 0.000 abstract 1
- 241001148111 Brucella suis Species 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/098—Brucella
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Vaccine against brucellosis comprises, in a suitable vehicle, the phenol-insoluble fraction (A) of Brucella abortus, esp. the strain B19. Pref. (A) is 1.7-2.3, esp. 2, mg (dry basis) per ml solvent and the vaccine is esp. formulated in unit doses of 0.5 ml. The pref. vehicle is a phenol-contg. physiological solvent. The vaccine is made from intact B.abortus cells by (1) removal of lipids (2) drying (3) extracting with phenol (esp. phenol satd. with water), at about 60 deg.C (4) washing the filtered and purified prod. and (5) forming into a homogeneous, sterile suspension. The vaccine is suitable for admin. to humans, e.g. farm workers or veterinary surgeons, and is effective against B. melitensis and B. suis as well as B. abortus. It is nontoxic and induces only very mild hypersensitivity reactions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8110789A FR2506615A1 (en) | 1981-06-01 | 1981-06-01 | Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES512691A0 ES512691A0 (en) | 1983-06-01 |
| ES8306594A1 true ES8306594A1 (en) | 1983-06-01 |
Family
ID=9259055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES512691A Expired ES8306594A1 (en) | 1981-06-01 | 1982-05-31 | Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU555214B2 (en) |
| ES (1) | ES8306594A1 (en) |
| FR (1) | FR2506615A1 (en) |
| GR (1) | GR76448B (en) |
| IL (1) | IL65920A (en) |
| IT (1) | IT1157306B (en) |
| PT (1) | PT74968B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1227892B (en) * | 1988-12-13 | 1991-05-14 | Alberto Indrio | PHARMACEUTICAL COMPOSITIONS WITH ANTI-PRESSURE AND ANXIOLYTIC ACTIVITY |
| IT1237538B (en) * | 1989-12-22 | 1993-06-08 | PHARMACEUTICAL COMPOSITIONS FOR DRUG DEPENDENCE THERAPY | |
| RU2398597C1 (en) * | 2008-12-22 | 2010-09-10 | Государственное научное учреждение Всероссийский научно-исследовательский институт бруцеллеза и туберкулеза животных Сибирского отделения Российской академии сельскохозяйственных наук | Method for producing protective antigen brucella complex |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1056839A (en) * | 1963-09-19 | 1967-02-01 | Johnson & Johnson | Brucella antigen |
| FR2035795A1 (en) * | 1969-03-31 | 1970-12-24 | Merieux Inst | Anti-brucellosis vaccine prepn |
| GB1285057A (en) * | 1969-05-28 | 1972-08-09 | Secr Defence | Improvements in brucellosis vaccines |
| GB1352125A (en) * | 1970-07-16 | 1974-05-08 | Wellcome Found | Antigenic extracts |
| FR2287238A1 (en) * | 1974-10-11 | 1976-05-07 | Agronomique Inst Nat Rech | Anti brucellosis vaccine - consisting of the covering or walls of brucella cells free from their cytoplasmic contents |
-
1981
- 1981-06-01 FR FR8110789A patent/FR2506615A1/en active Granted
-
1982
- 1982-05-25 GR GR68259A patent/GR76448B/el unknown
- 1982-05-28 PT PT74968A patent/PT74968B/en unknown
- 1982-05-31 AU AU84329/82A patent/AU555214B2/en not_active Ceased
- 1982-05-31 IL IL65920A patent/IL65920A/en not_active IP Right Cessation
- 1982-05-31 IT IT21603/82A patent/IT1157306B/en active
- 1982-05-31 ES ES512691A patent/ES8306594A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU8432982A (en) | 1982-12-09 |
| IL65920A0 (en) | 1982-08-31 |
| GR76448B (en) | 1984-08-10 |
| IT1157306B (en) | 1987-02-11 |
| FR2506615B1 (en) | 1984-10-26 |
| IL65920A (en) | 1985-09-29 |
| IT8221603A0 (en) | 1982-05-31 |
| FR2506615A1 (en) | 1982-12-03 |
| ES512691A0 (en) | 1983-06-01 |
| AU555214B2 (en) | 1986-09-18 |
| PT74968B (en) | 1984-08-02 |
| PT74968A (en) | 1982-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DZ562A1 (en) | Anti-inflammatory products derived from methylenedihosphonic acid and their preparation process. | |
| FR2596393B1 (en) | HYDROXY-3 DIHYDROXYOXOPHOSPHORIO-4 BUTANOIC ACID DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM | |
| OA08385A (en) | Dietetic product with purifying and anti-diarrheal activity and its method of preparation. | |
| NL193085B (en) | Method for the recovery of human white blood cell interferon, as well as a pharmaceutical preparation with the interferon thus obtained. | |
| FR2594438B1 (en) | INDOLIZINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE COMPOSITIONS CONTAINING SAME | |
| NO870390L (en) | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE N6-SUBSTITUTED ADENOSINES. | |
| SE8201351L (en) | SET TO MAKE LIPOSOM PREPARATIONS | |
| EP0339237A3 (en) | Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | |
| PT84898A (en) | Process for the preparation of pharmaceutical compositions comprising 2-phenyl-1,2-benzisoselenazol-3 (2h)-one useful for the treatment of diseases caused by oxidative stress | |
| IE871203L (en) | Formulations containing unsaturated fatty acids | |
| GB8802507D0 (en) | Influenza vaccine | |
| OA05575A (en) | New indolizine derivatives, their preparation process and the compositions containing them. | |
| AU611113B2 (en) | Basically substituted phenylacetonitriles, their preparation and drugs containing these compounds | |
| EP0249248A3 (en) | Purine derivatives | |
| ES8306594A1 (en) | Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells | |
| JPS5461194A (en) | Preparation of n22substituted 2*66diaminonebularin | |
| EP0207287A3 (en) | Indole derivatives, process for their preparation and cosmetic preparation containing them | |
| OA06258A (en) | Process for the preparation of new acetylenic derivatives of androst-4-ene. | |
| MX168595B (en) | PROCEDURE FOR THE PREPARATION OF AZOLYL DERIVATIVES THAT HAVE FUNGICIDE ACTIVITY | |
| ES514748A0 (en) | "PROCEDURE FOR THE ELIMINATION OF ORGANIC IMPURITIES FROM PHOSPHORIC ACID". | |
| NO882255D0 (en) | PROCEDURE FOR THE PREPARATION OF OLEFINMALINE ACID ANHYRIDE COPOLYMES IN THE FORM OF PARTICLES. | |
| JPS5536403A (en) | Preparation of 1-benzazonine derivative | |
| BE882684A (en) | PROCESS FOR THE PREPARATION OF AN ANTIRABIC VACCINE AND VACCINE OBTAINED ACCORDING TO THIS PROCESS | |
| HUT55793A (en) | Process for producing new monosaccharide derivatives and pharmaceutical compositions containing them | |
| FR2595703B1 (en) | NOVEL PHOSPHOLIPIDS, THEIR PROCESS AND PREPARATIONS THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970505 |