ES8307734A1 - "procedimiento de producir derivados amidicos". - Google Patents

"procedimiento de producir derivados amidicos".

Info

Publication number
ES8307734A1
ES8307734A1 ES513889A ES513889A ES8307734A1 ES 8307734 A1 ES8307734 A1 ES 8307734A1 ES 513889 A ES513889 A ES 513889A ES 513889 A ES513889 A ES 513889A ES 8307734 A1 ES8307734 A1 ES 8307734A1
Authority
ES
Spain
Prior art keywords
fused
cycloalkyl
aryl
alkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513889A
Other languages
English (en)
Other versions
ES513889A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pharmaceutical Corp
Original Assignee
USV Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pharmaceutical Corp filed Critical USV Pharmaceutical Corp
Publication of ES8307734A1 publication Critical patent/ES8307734A1/es
Publication of ES513889A0 publication Critical patent/ES513889A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/12—Dithiocarbonic acids; Derivatives thereof
    • C07C329/14—Esters of dithiocarbonic acids
    • C07C329/16—Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/14—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/02—Thiosulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS AMIDICOS, DE FORMULA (I), EN LA QUE M Y N VALEN 0-2 Y 0-4, RESPECTIVAMENTE; Y R<1-R<7, M E Y PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE SUSTITUCION DEL HIDROGENO DEL GRUPO -SH DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), POR UN SUSTITUYENTE REPRESENTATIVO DEL GRUPO R<7; SEGUIDA DE LA TRANSFORMACION OPCIONAL A LOS CORRESPONDIENTES SULFOXIDOS Y/O SULFONAS POR REACCION CON PEROXIDOS O PERACIDOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIHIPERTENSORA E INHIBIDORA DE LAS ENZIMAS DE CONVERSION DE LA ANGIOTENSINA.
ES513889A 1981-06-01 1982-06-01 "procedimiento de producir derivados amidicos". Granted ES513889A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/269,166 US4507316A (en) 1981-06-01 1981-06-01 Antihypertensive compounds

Publications (2)

Publication Number Publication Date
ES8307734A1 true ES8307734A1 (es) 1983-08-01
ES513889A0 ES513889A0 (es) 1983-08-01

Family

ID=23026080

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513889A Granted ES513889A0 (es) 1981-06-01 1982-06-01 "procedimiento de producir derivados amidicos".

Country Status (10)

Country Link
US (1) US4507316A (es)
EP (1) EP0066254B1 (es)
JP (1) JPS58958A (es)
AU (1) AU8411682A (es)
DE (1) DE3275375D1 (es)
DK (1) DK241882A (es)
ES (1) ES513889A0 (es)
NZ (1) NZ200798A (es)
PH (1) PH19562A (es)
ZA (1) ZA823710B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284510A3 (en) * 1987-03-24 1990-08-22 Asahi Breweries, Ltd. N-[N alpha-(1(S)-carboxy-3-cyclohexyl-propyl)-1-lysyl] N-cyclopentylglycine as antihypertensives
US5292926A (en) * 1988-01-25 1994-03-08 Santen Pharmaceutical Co., Ltd. Cysteine derivatives
JP7074904B1 (ja) 2021-03-16 2022-05-24 東海カーボン株式会社 黒鉛電極、電気炉

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297295A (en) * 1976-09-17 1981-10-27 Stauffer Chemical Company N-(Benzenesulfonyl) thiocarbamates-herbicidal antidotes
AU4091178A (en) * 1977-10-25 1980-04-24 Merck & Co Inc Substituted mercapto acid amides
FR2447373A1 (fr) * 1979-01-24 1980-08-22 Rhone Poulenc Agrochimie Produits derives de l'aniline ayant une activite antifongique ainsi que leur procede de preparation
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
DE2946910A1 (de) * 1979-11-21 1981-07-02 Hoechst Ag, 6230 Frankfurt Fungizide sulfonyl-, bzw. sulfinylacetanilide
ZA811340B (en) * 1980-06-09 1982-03-31 Morton Norwich Products Inc N-(cycloalkyl)amino acid compounds

Also Published As

Publication number Publication date
DE3275375D1 (en) 1987-03-12
NZ200798A (en) 1986-04-11
AU8411682A (en) 1982-12-09
DK241882A (da) 1982-12-02
PH19562A (en) 1986-05-21
US4507316A (en) 1985-03-26
EP0066254A1 (en) 1982-12-08
ES513889A0 (es) 1983-08-01
EP0066254B1 (en) 1987-02-04
ZA823710B (en) 1983-03-30
JPS58958A (ja) 1983-01-06

Similar Documents

Publication Publication Date Title
ES8204739A1 (es) Un procedimiento para preparar compuestos de cefem
HU895609D0 (en) Process for the preparation of novel 1,4-diazepine derivatives and pharmaceutical compositions containing such compounds
SE8005128L (sv) Antihypertensiva amider
DE3065304D1 (en) Morpholine derivatives, pharmaceutical compositions containing them and processes for their preparation
ES8306160A1 (es) &#34;procedimiento para preparar un nuevo compuesto de cefem&#34;.
ES8301927A1 (es) Procedimiento de preparacion de acidos azabiciclohexano car-boxilicos y de sus sales
ES8307239A1 (es) Procedimiento para la preparacion de acidos (2-oxo-3-tetrahidrotienilcarbamoil)-alquiltio aceticos.
EP0233793A3 (en) Decahydroquinoline derivatives, process for their preparation, intermediates for their preparation, their use as medicaments and compositions containing them
TW249804B (es)
ES482472A1 (es) Procedimiento para la preparacion de isoquinoleinas.
PH20421A (en) Derivatives of piperidinedione for protecting the myocardium presenting an anti-arrythmic activity and pharmaceutical compositions containing them
ZA818934B (en) Trisubstituted pyrimido pyrimidines,processes for their preparation,and pharmaceutical compositions thereof
ES8404976A1 (es) Procedimiento para preparar nuevos derivados de encefalina.
DE3068961D1 (en) 6,7-benzomorphan derivatives, processes for their production, pharmaceutical compositions containing said derivatives and their use as pharmaceuticals
ES8401068A1 (es) Procedimiento para la preparacion de derivados de corinanteina, asi como de sus sales de adicion acida fisiologicamente inocuas.
ES466192A1 (es) Procedimiento para la obtencion de derivados de la isoqui- noleina.
ES461764A1 (es) Procedimiento para preparar oximas derivadas del acido 3- carbamoiloximetil-7-aminotiazolilacetamido cefalosporanico.
ES8202017A1 (es) Procedimiento para la obtencion de derivados del amino-tia- diazolilo
ES8406442A1 (es) Un procedimiento para preparar compuestos de acido quinolilacetico
ES8105319A1 (es) Procedimiento de preparacion de derivados pirazolo (1,5-c) quinazolinos y de sus sales de adicion acidas
ES8401059A1 (es) Procedimiento para la preparacion de fenoleteres biciclicos.
DE3665593D1 (en) Peptide immunostimulants
ES481969A1 (es) Un procedimiento para preparar nuevos analogos de cefalospo-rina.
ES8400420A1 (es) &#34;procedimiento para la fabricacion de derivados n- susbtituidos de la tetrahidroisftalimida&#34;.
GB1076867A (en) Improvements in or relating to 2,4-diamino-6-substituted pyrimidines