ES8307735A1 - Aminothiol derivatives, their preparation and use, and compositions containing them - Google Patents

Aminothiol derivatives, their preparation and use, and compositions containing them

Info

Publication number
ES8307735A1
ES8307735A1 ES505037A ES505037A ES8307735A1 ES 8307735 A1 ES8307735 A1 ES 8307735A1 ES 505037 A ES505037 A ES 505037A ES 505037 A ES505037 A ES 505037A ES 8307735 A1 ES8307735 A1 ES 8307735A1
Authority
ES
Spain
Prior art keywords
alkyl
group
phenyl
substituted
radicals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505037A
Other languages
Spanish (es)
Other versions
ES505037A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Continental Pharma Inc
Original Assignee
Continental Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma Inc filed Critical Continental Pharma Inc
Publication of ES8307735A1 publication Critical patent/ES8307735A1/en
Publication of ES505037A0 publication Critical patent/ES505037A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivatives of aminothiols having a number of therapeutic properties, e.g. vasodilating, antihypertensive, hypolipidaemiant, antithrombotic, antiarthritic, immodulatory and/or antimitotic properties of the general formula (I):- < IMAGE > wherein: R1 represents hydrogen or C1-10 alkyl R2 represents hydrogen or C1-4 alkyl R1 and R2 can form, with the adjacent carbon atoms, C3-8 to cycloalkyl R3 represents hydrogen, C1-3 alkyl, C1-3 alkanoylthio, C1-3 alkyloxycarbonylthio, C1-10 alkylthio or a radical -(S)n-CR1R2-CH2-NR4R5, n being 1 or 2 R4 and R5, which can be identical or different, represent: hydrogen, C1-6 alkyl, possibly substituted by: a hydroxyl group, a carboxyl or a linear or branched C1-C2 alkoxycarbonyl group, a naphthyloxy, a phenyl, phenoxy, phenylthio or benzyloxy group optionally substituted by one, two or more halogen atoms such as chlorine, by one, two or more, C1-4 alkyl radicals, by one, two or more C1-4 alkyloxy radicals, a C1-4 alkoxy or alkylthio group, a C1-4 alkylamino group possibly substituted by a phenyl ring, a C1-6 alkylcarboxamido group possibly substituted by a phenyl or phenoxy group, a C3-8 cycloalkylcarboxamido group, C3-8 cycloalkyl, C3-16 alkenyl, C3-8 alkynyl, R4 and R5 can form with the adjacent nitrogen atom a heterocycle such as piperidine, pyrrolidine, morpholine, piperazine, possibly substituted in the 4 position by benzyl, C1-4 alkyl or phenyl which can itself be substituted by one, two or more halogen atoms such as fluorine and chlorine, C1, C2 or C3 alkyl radicals, C1, C2 or C3 alkoxy radicals R3 and R4 can form a thiazolidine cycle optionally substituted in the 2 position by one or two C1, C2 or C3 alkyl groups or a thiazolidinone cycle R1, R2, R3, R4 and R5 cannot simultaneously represent hydrogen, and non-toxic and pharmaceutically utilisable salts of these derivatives.
ES505037A 1980-08-29 1981-08-28 PROCEDURE FOR THE PREPARATION OF AMINOTIOL DERIVATIVES Granted ES505037A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU82738A LU82738A1 (en) 1980-08-29 1980-08-29 DERIVATIVES OF AMINOTHIOLS, THEIR PREPARATION AND USE AS WELL AS COMPOSITIONS CONTAINING THESE DERIVATIVES

Publications (2)

Publication Number Publication Date
ES8307735A1 true ES8307735A1 (en) 1983-08-16
ES505037A0 ES505037A0 (en) 1983-08-16

Family

ID=19729472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505037A Granted ES505037A0 (en) 1980-08-29 1981-08-28 PROCEDURE FOR THE PREPARATION OF AMINOTIOL DERIVATIVES

Country Status (18)

Country Link
JP (1) JPS5798255A (en)
AU (1) AU7465481A (en)
BE (1) BE890116A (en)
DE (1) DE3133293A1 (en)
DK (1) DK382281A (en)
ES (1) ES505037A0 (en)
FI (1) FI812640A7 (en)
FR (1) FR2489325A1 (en)
GB (1) GB2083036A (en)
GR (1) GR74348B (en)
IL (1) IL63664A0 (en)
IT (1) IT1137642B (en)
LU (1) LU82738A1 (en)
NL (1) NL8103993A (en)
NO (1) NO812944L (en)
PT (1) PT73593B (en)
SE (1) SE8104958L (en)
ZA (1) ZA815912B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8405896D0 (en) * 1984-03-07 1984-04-11 Sandoz Ltd Organic compounds
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2505870A (en) * 1947-05-09 1950-05-02 Phillips Petroleum Co Secondary and tertiary alkylthiol amines and their production
US3337625A (en) * 1961-09-18 1967-08-22 Lilly Co Eli Amino-acetylenic compounds
US3312732A (en) * 1962-02-28 1967-04-04 Monsanto Res Corp Aminoalkyl aminoalkanethiols
US3356730A (en) * 1964-11-25 1967-12-05 Monsanto Res Corp Mercaptoalkyl oxyalkyl amines
GB1138738A (en) * 1966-12-01 1969-01-01 Eastman Kodak Co Aziridine derivatives
US3622676A (en) * 1968-11-20 1971-11-23 Constance Anthony D Alonzo Smoking suppression
CA992105A (en) * 1970-03-26 1976-06-29 Exxon Research And Engineering Company Polythioethers formed by anionic ring opening of episulfides
BE789629A (en) * 1971-10-05 1973-04-03 Sandoz Sa NEW DERIVATIVES OF PLEUROMUTILINE, THEIR PREPARATION AND THERAPEUTIC APPLICATION
CH632906A5 (en) * 1976-08-09 1982-11-15 Givaudan & Cie Sa Use of bifunctional N,S-compounds as flavourings

Also Published As

Publication number Publication date
JPS5798255A (en) 1982-06-18
NL8103993A (en) 1982-03-16
IT1137642B (en) 1986-09-10
IL63664A0 (en) 1981-11-30
ES505037A0 (en) 1983-08-16
FR2489325A1 (en) 1982-03-05
DE3133293A1 (en) 1982-04-08
ZA815912B (en) 1982-08-25
NO812944L (en) 1982-03-01
FI812640L (en) 1982-03-01
LU82738A1 (en) 1982-05-10
FI812640A7 (en) 1982-03-01
AU7465481A (en) 1982-03-04
DK382281A (en) 1982-03-01
PT73593B (en) 1982-11-10
IT8123611A0 (en) 1981-08-24
SE8104958L (en) 1982-03-01
PT73593A (en) 1981-09-01
GR74348B (en) 1984-06-26
GB2083036A (en) 1982-03-17
BE890116A (en) 1982-03-01

Similar Documents

Publication Publication Date Title
CA2014518A1 (en) Lipopolyamines, their preparation and their use
NZ307505A (en) Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
DK151883C (en) 2- OR 3-ALKYL-SUBSTITUTED N-HYDROXYALKYL MORPHOLINES AND PREPARATIONS CONTAINING THEM
HU904785D0 (en) Process for the production of medicaments
ZA895175B (en) Piperidine derivatives
BR1101136A (en) Derived from pristinamycin iib, (diethylamino-2 methyl-1 ethyl) sulfinyl-26 pristinamycin iib, (diethylamino-2 propyl) sulfonyl-26 pristinamycin iib, (diisopropylamino-2 ethyl) sulfonyl-26 pristinamycin iib, process of preparing a new derivative of pristinamycin iib and pharmaceutical composition
GR3034023T3 (en) Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
IS3828A (en) Similar method for preparing new derivatives of thiazolidinone and oxazolidinone useful for vasodilatation
ES8704933A1 (en) New pyridazine compositions, production process thereof and fungicides and algicides containing them.
HUT59090A (en) Process for producing n-benzyl-n1-phenyl-thiourea- and n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing them
SE8104958L (en) AMINOTIOL DERIVATIVES, PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING SUCH DERIVATIVES
IL75987A0 (en) 1,6-naphthyridine derivatives,their preparation and pharmaceutical compositions containing them
ATE212637T1 (en) ANTIBIOTICALLY EFFECTIVE CEPHALOSPORINS AND METHOD FOR THE PRODUCTION THEREOF
ES488387A1 (en) Condensed derivatives of pyrrolidine or piperidine, process for their preparation and composition containing them.
DE3462333D1 (en) Synergistin derivatives, their preparation and pharmaceutical compositions thereof
DE3570669D1 (en) 3-alcoxy-2-(n-pyrrolidino)-n-pyridyl-n-furyl(or thienyl)-methyl propyl amines, their preparation and pharmaceutical compositions containing them
SE7905940L (en) NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0176049A3 (en) Aminoalkylnaphtalene derivatives having pharmacological activities
DE3864336D1 (en) Aromatische thioaether.
IE820160L (en) Heterocyclic benzamide derivatives
IL59358A (en) Hydroxytetrahydro(phenoxymethyl)-imidazothiazole and thiazolopyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL61771A0 (en) 4-amino-2,6-diaryl-tetrahydrothiopyrans,their preparation and pharmaceutical compositions containing them
EP0273357A3 (en) Fluorine-containing macrolide compounds, pharmaceutical compositions comprising the same and their use for the manufacture of medicaments
IT1261958B (en) 2-(substituted imino)-thiazolidines and process for their preparation