ES8307762A1 - Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina. - Google Patents

Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina.

Info

Publication number
ES8307762A1
ES8307762A1 ES508454A ES508454A ES8307762A1 ES 8307762 A1 ES8307762 A1 ES 8307762A1 ES 508454 A ES508454 A ES 508454A ES 508454 A ES508454 A ES 508454A ES 8307762 A1 ES8307762 A1 ES 8307762A1
Authority
ES
Spain
Prior art keywords
processes
preparation
compositions containing
cancer agents
quinazoline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508454A
Other languages
English (en)
Other versions
ES508454A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAT RES DEV
National Research Development Corp UK
Original Assignee
NAT RES DEV
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAT RES DEV, National Research Development Corp UK filed Critical NAT RES DEV
Publication of ES8307762A1 publication Critical patent/ES8307762A1/es
Publication of ES508454A0 publication Critical patent/ES508454A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 2-AMINO-4-HIDROXIQUINAZOLINA, DE FORMULA (I), EN LA QUE R REPRESENTA UN GRUPO HIDROCARBURO INSATURADO DE CADENA RECTA O RAMIFICADA, O UN GRUPO HIDROCARBURO SATURADO O INSATURADO, DE CADENA RECTA O RAMIFICADA, QUE PUEDE ESTAR SUSTITUIDO; N ES 0, 1, 2, 3 O 4; X REPRESENTA UN GRUPO HALOGENO, ARILO O ALQUILO C<1-C<4; E Y REPRESENTA UN RADICAL, Y SUS SALES Y ESTERES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN DESPROTEGER COMPLETA O PARCIALMENTE UN COMPUESTO DE FORMULA (II), EN LA QUE X Y N TIENEN LOS SIGNIFICADOS YA INDICADOS; R>2 ES EQUIVALENTE A R; R>1 ES HIDROGENO O UN GRUPO AMINO-PROTECTOR; E Y ES UN RADICAL EQUIVALENTE AL REPRESENTADO POR Y. DE APLICACION COMO AGENTES ANTI-TUMORALES EN EL TRATAMIEMTO DEL CANCER.
ES508454A 1979-12-19 1981-12-30 Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina. Granted ES508454A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7943715 1979-12-19
GB8006813 1980-02-28

Publications (2)

Publication Number Publication Date
ES8307762A1 true ES8307762A1 (es) 1983-08-01
ES508454A0 ES508454A0 (es) 1983-08-01

Family

ID=26273917

Family Applications (3)

Application Number Title Priority Date Filing Date
ES497884A Granted ES497884A0 (es) 1979-12-19 1980-12-18 Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina
ES508453A Granted ES508453A0 (es) 1979-12-19 1981-12-30 Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina.
ES508454A Granted ES508454A0 (es) 1979-12-19 1981-12-30 Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES497884A Granted ES497884A0 (es) 1979-12-19 1980-12-18 Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina
ES508453A Granted ES508453A0 (es) 1979-12-19 1981-12-30 Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina.

Country Status (17)

Country Link
US (2) US4447608A (es)
EP (1) EP0031237B1 (es)
AU (1) AU543237B2 (es)
CA (1) CA1184900A (es)
DE (1) DE3069468D1 (es)
DK (1) DK157019C (es)
ES (3) ES497884A0 (es)
FI (1) FI76791C (es)
GB (1) GB2065653B (es)
GR (1) GR72847B (es)
HU (1) HU193505B (es)
IE (1) IE51188B1 (es)
IL (1) IL61756A (es)
NO (1) NO154919C (es)
NZ (1) NZ195876A (es)
PT (1) PT72232B (es)
YU (1) YU321180A (es)

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US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
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US5187167A (en) * 1986-03-27 1993-02-16 Imperial Chemical Industries Plc Pharmaceutical compositions comprising quinazolin-4-one derivatives
US4833145A (en) * 1986-06-30 1989-05-23 The Trustees Of Princeton University 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
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US5223620A (en) * 1988-04-01 1993-06-29 Takeda Chemical Industries, Ltd. Pyrido[2,3-d]pyrimidine compounds useful as intermediates
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
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US5252573A (en) * 1988-12-15 1993-10-12 Imperial Chemical Industries Plc Anti-tumor agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US5160727A (en) * 1990-02-13 1992-11-03 Warner-Lambert Company Tumor cell sensitization method using quinazolinedione derivatives
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
ZA913730B (en) * 1990-05-30 1992-02-26 Ici Plc Anti-tumor compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
US5145854A (en) * 1991-11-27 1992-09-08 Nair Madhavan G 1-formyl-5,8,10-trideazafolates
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
CH684644A5 (de) * 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
US5821231A (en) * 1993-12-06 1998-10-13 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using same
US5770573A (en) * 1993-12-06 1998-06-23 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
WO1995015973A1 (en) * 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
JPH09509146A (ja) * 1993-12-06 1997-09-16 サイテル コーポレイション Ｃｓ−１ペプチド模擬物、組成物およびその使用法
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5593999A (en) * 1995-06-07 1997-01-14 Nair; Madhavan G. Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
CA2222545A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Quinazolines and pharmaceutical compositions
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
PT948604E (pt) * 1996-12-11 2004-10-29 Univ New York Medical Ct Produtos e metodos relacionados com pyk2
US6818440B2 (en) 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
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US6388063B1 (en) * 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
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US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
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US6683113B2 (en) 1999-09-23 2004-01-27 Pharmacia Corporation (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US6479552B2 (en) 1999-09-23 2002-11-12 G.D. Searle & Co. Use of substituted N, N-disubstituted diamino compounds for inhibiting cholesteryl ester transfer protein activity
US6677382B1 (en) 1999-09-23 2004-01-13 Pharmacia Corporation Substituted N,N-bis-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
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US6143776A (en) * 2000-02-02 2000-11-07 Sunesis Pharmaceuticals, Inc. Tosylproline analogs as thymidylate synthase inhibitors
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US20030027308A1 (en) * 2000-05-30 2003-02-06 Sugen Incorporated Novel human protein phosphatases identified from genomic sequencing
CA2321345A1 (fr) * 2000-10-02 2002-04-02 Abdelbast Guerfi Utilisation du graphite dans un composite pour reduire l'accumulation de glace
US20040157306A1 (en) * 2000-11-13 2004-08-12 Sugen Incorporated Mammalian protein phosphatases
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
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US7528141B2 (en) 2001-08-31 2009-05-05 Btg International Limited Use of cyclopenta[g]quinazoline derivatives for treating cancer
JP2005509418A (ja) * 2001-11-13 2005-04-14 スージェン・インコーポレーテッド 哺乳動物蛋白質ホスファターゼ
US7537774B2 (en) * 2005-12-23 2009-05-26 Orion Therapeautics, Llc Therapeutic formulation
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US3471498A (en) * 1967-08-11 1969-10-07 Parke Davis & Co Certain n-p-((2,4-diamino-6-quinazolinyl)-methyl)benzoylamino acids

Also Published As

Publication number Publication date
ES8300716A1 (es) 1982-11-01
IL61756A0 (en) 1981-01-30
DK540080A (da) 1981-06-20
AU543237B2 (en) 1985-04-04
NO154919B (no) 1986-10-06
HU193505B (en) 1987-10-28
YU321180A (en) 1983-06-30
FI803957L (fi) 1981-06-20
GR72847B (es) 1983-12-07
FI76791B (fi) 1988-08-31
NZ195876A (en) 1983-11-18
EP0031237A1 (en) 1981-07-01
ES8308314A1 (es) 1983-09-01
AU6549580A (en) 1981-06-25
FI76791C (fi) 1988-12-12
US4447608A (en) 1984-05-08
DK157019B (da) 1989-10-30
DE3069468D1 (en) 1984-11-22
IE51188B1 (en) 1986-10-29
PT72232B (en) 1981-11-02
NO803868L (no) 1981-06-22
GB2065653B (en) 1983-03-09
CA1184900A (en) 1985-04-02
US4564616A (en) 1986-01-14
ES508453A0 (es) 1983-09-01
EP0031237B1 (en) 1984-10-17
GB2065653A (en) 1981-07-01
DK157019C (da) 1990-03-26
ES508454A0 (es) 1983-08-01
IE802672L (en) 1981-06-19
IL61756A (en) 1987-02-27
ES497884A0 (es) 1982-11-01
PT72232A (en) 1981-01-01
NO154919C (no) 1987-01-14

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506