ES8307894A1 - Procedimiento para aislar antibioticos de carbapenem, quimicamente inestables. - Google Patents

Procedimiento para aislar antibioticos de carbapenem, quimicamente inestables.

Info

Publication number
ES8307894A1
ES8307894A1 ES517485A ES517485A ES8307894A1 ES 8307894 A1 ES8307894 A1 ES 8307894A1 ES 517485 A ES517485 A ES 517485A ES 517485 A ES517485 A ES 517485A ES 8307894 A1 ES8307894 A1 ES 8307894A1
Authority
ES
Spain
Prior art keywords
antibiotics
isolation
chemically unstable
fermentation solutions
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517485A
Other languages
English (en)
Other versions
ES517485A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES517485A0 publication Critical patent/ES517485A0/es
Publication of ES8307894A1 publication Critical patent/ES8307894A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA AISLAR ANTIBIOTICOS DE CARBAPENEM, QUIMICAMENTE INESTABLES, A PARTIR DE SOLUCIONES DE FERMENTACION. CARACTERIZADO PORQUE LOS ANTIBIOTICOS FORMADOS SE ADSORBEN EN ADECUADAS RESINAS INTERCAMBIADORAS DE IONES, AL OBJETO DE CONVERTIRLOS EN UNA FORMA ESTABILIZADA; PORQUE COMO RESINA INTERCAMBIADORA DE IONES SE EMPLEAN INTERCAMBIADORES DE ANIONES CON BASIDAD DESDE MEDIA HASTA FUERTE; PORQUE LA RESINA INTERCAMBIADORA DE IONES SE AÑADE EN EL MOMENTO OPORTUNO A LA SOLUCION DE FERMENTACION Y ESTA SE ENFRIA RAPIDAMENTE; Y PORQUE LOS INTERCAMBIADORES DE ANIONES SE SEPARAN DE LA SOLUCION DE FERMENTACION POR FILTRACION A TRAVES DE UN TAMIZ ADECUADO.
ES517485A 1981-11-21 1982-11-19 Procedimiento para aislar antibioticos de carbapenem, quimicamente inestables. Expired ES8307894A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813146190 DE3146190A1 (de) 1981-11-21 1981-11-21 Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen

Publications (2)

Publication Number Publication Date
ES517485A0 ES517485A0 (es) 1983-08-01
ES8307894A1 true ES8307894A1 (es) 1983-08-01

Family

ID=6146895

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517485A Expired ES8307894A1 (es) 1981-11-21 1982-11-19 Procedimiento para aislar antibioticos de carbapenem, quimicamente inestables.

Country Status (7)

Country Link
US (1) US4529545A (es)
EP (1) EP0080166B1 (es)
JP (1) JPS58101696A (es)
AT (1) ATE15227T1 (es)
CA (1) CA1199885A (es)
DE (2) DE3146190A1 (es)
ES (1) ES8307894A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3973015A (en) * 1970-08-03 1976-08-03 Eli Lilly And Company Antibiotic A16884
US4054564A (en) * 1970-08-03 1977-10-18 Eli Lilly And Company 7-(5-Amino-5-carboxyvaleramido)-7-methoxycephalosporanic acid
US3962427A (en) * 1972-12-08 1976-06-08 Eli Lilly And Company Antibiotic nebramycin factor VII
US4000161A (en) * 1974-12-19 1976-12-28 Merck & Co., Inc. Process for purifying thienamycin
US3993748A (en) * 1975-01-20 1976-11-23 The Upjohn Company Antibiotic U-47,929 and its preparation
DE2528622A1 (de) * 1975-06-26 1977-01-13 Bayer Ag Verfahren zur reinigung der bei der enzymatischen spaltung von beta-lactam- antibiotika anfallenden produkte
US4229534A (en) * 1975-11-21 1980-10-21 Merck & Co., Inc. Acetylthienamycin production
US4282322A (en) * 1975-11-24 1981-08-04 Merck & Co., Inc. Process for enzymatic deacylation of antibiotics
DK497476A (da) * 1975-11-24 1977-05-25 Merck & Co Inc Fremgangsmade til fremstilling af et antibiotisk stof
SE7801695L (sv) * 1977-03-01 1978-09-02 Merck & Co Inc Tienamycin
GR62185B (en) * 1977-03-31 1979-03-02 Panlabs Inc Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase
GB1583841A (en) * 1977-07-14 1981-02-04 Beecham Group Ltd Antibiotics mm4550 mm13902 and mm17880 preparation
JPS55136282A (en) * 1979-04-06 1980-10-23 Shionogi & Co Ltd Novel antibiotic pa-31088-4
US4247640A (en) * 1979-07-23 1981-01-27 Merck & Co., Inc. Fermentation process for 6-hydroxymethyl-2-(2-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acid
EP0024447B1 (en) * 1979-08-28 1983-07-20 Merck & Co. Inc. Process for purifying thienamycin
KR840001256B1 (ko) * 1980-08-19 1984-09-01 메이지세카 주식회사 신항생물질 sf-2103a 물질의 제조법

Also Published As

Publication number Publication date
DE3265895D1 (en) 1985-10-03
ES517485A0 (es) 1983-08-01
EP0080166B1 (de) 1985-08-28
US4529545A (en) 1985-07-16
JPS58101696A (ja) 1983-06-16
DE3146190A1 (de) 1983-06-16
EP0080166A1 (de) 1983-06-01
CA1199885A (en) 1986-01-28
ATE15227T1 (de) 1985-09-15

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