ES8308835A1 - Un procedimiento para la preparacion de derivados de etanola-mina. - Google Patents

Un procedimiento para la preparacion de derivados de etanola-mina.

Info

Publication number
ES8308835A1
ES8308835A1 ES513967A ES513967A ES8308835A1 ES 8308835 A1 ES8308835 A1 ES 8308835A1 ES 513967 A ES513967 A ES 513967A ES 513967 A ES513967 A ES 513967A ES 8308835 A1 ES8308835 A1 ES 8308835A1
Authority
ES
Spain
Prior art keywords
straight
branched
hydrogen
alkyl
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513967A
Other languages
English (en)
Other versions
ES513967A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8308835A1 publication Critical patent/ES8308835A1/es
Publication of ES513967A0 publication Critical patent/ES513967A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/52—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition by dehydration and rearrangement involving two hydroxy groups in the same molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ETALNOLAMINA Y DE SUS SALES Y ACIL DERIVADOS HIDROLIZABLES ~AIN VIVO~B, DE FORMULA (I), EN LA QUE R>1 Y R>2 SON HIDROGENO O METILO; R>3, R>4 Y R>5 PUEDEN SER VARIOS RADICALES; Y N VALE 1 O 2. CONSISTE EN LA REACCION DE REDUCCION DE UN GRUPO OXO Y/O UN DOBLE ENLACE Y/O UN RESTO REDUCIBLE A UN GRUPO R>4, DE UN COMPUESTO DE FORMULA (II) EN LA QUE R>1>1, R>1>2, R>1>3, R>1>4, R>1>5, R>1>6 Y R>1>7 PUEDEN SER VARIOS RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REDUCCION SE LLEVA A CABO MEDIANTE HIDRUROS COMPLEJOS O POR REDUCCION CATALITICA, EN UN DISOLVENTE ALCANOLICO INFERIOR, A TEMPERATURAS ENTRE 0 C Y 20 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIOBESIDAD Y/O ANTIHIPERGLICEMICA Y/O ANTIINFLAMATORIA Y/O INHIBIDORA DE LA AGREGACION PLAQUETARIA.
ES513967A 1981-07-11 1982-07-12 Un procedimiento para la preparacion de derivados de etanola-mina. Granted ES513967A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8121442 1981-07-11
GB8139024 1981-12-30

Publications (2)

Publication Number Publication Date
ES8308835A1 true ES8308835A1 (es) 1983-08-01
ES513967A0 ES513967A0 (es) 1983-08-01

Family

ID=26280094

Family Applications (3)

Application Number Title Priority Date Filing Date
ES513967A Granted ES513967A0 (es) 1981-07-11 1982-07-12 Un procedimiento para la preparacion de derivados de etanola-mina.
ES520690A Granted ES520690A0 (es) 1981-07-11 1983-03-16 Un procedimiento para la preparacion de derivados de etanolamina.
ES520691A Expired ES8404312A1 (es) 1981-07-11 1983-03-16 Un procedimiento para la preparacion de derivados de etanolamina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES520690A Granted ES520690A0 (es) 1981-07-11 1983-03-16 Un procedimiento para la preparacion de derivados de etanolamina.
ES520691A Expired ES8404312A1 (es) 1981-07-11 1983-03-16 Un procedimiento para la preparacion de derivados de etanolamina.

Country Status (5)

Country Link
EP (1) EP0070133B1 (es)
AU (1) AU553070B2 (es)
DE (1) DE3271132D1 (es)
ES (3) ES513967A0 (es)
NZ (1) NZ201217A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
GB8310556D0 (en) * 1983-04-19 1983-05-25 Beecham Group Plc Compounds
GB8415377D0 (en) * 1984-06-15 1984-07-18 Beecham Group Plc Compounds
GB8528633D0 (en) 1985-11-21 1985-12-24 Beecham Group Plc Compounds
CA1287061C (en) * 1986-06-27 1991-07-30 F. Hoffmann-La Roche Ag Pyridine ethanolamine derivatives
DE3631009A1 (de) * 1986-09-12 1988-03-24 Bayer Ag Arylethanolamine, verfahren zu ihrer herstellung und ihre verwendung zur leistungsfoerderung
GB8910374D0 (en) * 1989-05-05 1989-06-21 Ici Plc Chemical compounds
GB9207964D0 (en) * 1992-04-10 1992-05-27 Ici Plc Chemical compounds
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US6451814B1 (en) * 2000-07-17 2002-09-17 Wyeth Heterocyclic β-3 adrenergic receptor agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
DK268779A (da) * 1978-07-03 1980-01-04 Lilly Co Eli Fremgangsmaade til fremstilling af phenethanolaminer
US4338333A (en) * 1979-06-16 1982-07-06 Beecham Group Limited Ethanamine derivatives their preparation and use in pharmaceutical compositions
DE3070865D1 (en) * 1979-11-15 1985-08-14 Beecham Group Plc Secondary ethanol amines, their preparation and their use in pharmaceutical compositions
DE3169094D1 (en) * 1980-11-20 1985-03-28 Beecham Group Plc Secondary amines

Also Published As

Publication number Publication date
ES520691A0 (es) 1984-05-01
AU8579082A (en) 1983-01-20
NZ201217A (en) 1986-05-09
DE3271132D1 (en) 1986-06-19
ES8404311A1 (es) 1984-05-01
ES513967A0 (es) 1983-08-01
ES520690A0 (es) 1984-05-01
EP0070133A3 (en) 1983-05-18
AU553070B2 (en) 1986-07-03
EP0070133A2 (en) 1983-01-19
EP0070133B1 (en) 1986-05-14
ES8404312A1 (es) 1984-05-01

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