ES8308885A1 - Un procedimiento para la preparacion de acidos benzoxepino 4,3-b)pirrol-2-aceticos sustituidos. - Google Patents

Un procedimiento para la preparacion de acidos benzoxepino 4,3-b)pirrol-2-aceticos sustituidos.

Info

Publication number
ES8308885A1
ES8308885A1 ES513560A ES513560A ES8308885A1 ES 8308885 A1 ES8308885 A1 ES 8308885A1 ES 513560 A ES513560 A ES 513560A ES 513560 A ES513560 A ES 513560A ES 8308885 A1 ES8308885 A1 ES 8308885A1
Authority
ES
Spain
Prior art keywords
analgesic
formula
inflammatory agents
substituted pyrrole
tricyclic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513560A
Other languages
English (en)
Other versions
ES513560A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/329,842 external-priority patent/US4380645A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8308885A1 publication Critical patent/ES8308885A1/es
Publication of ES513560A0 publication Critical patent/ES513560A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS BENZOXEPINO 4,3-B PIRROL-2-ACETICOS SUSTITUIDOS, Y DE SUS SALES, ESTERES O AMIDAS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X, Y, Z, R, R>1 Y R>3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE DESCARBOXILACION DE UN DIACIDO DE FORMULA (II) EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), O UN ESTER T-BUTILICO O BENZHIDRILICO DEL MISMO, POR TRATAMIENTO CON UN ACIDO, TAL COMO ACIDO TRIFLUORACETICO Y OTRO HALOGENOACETICO, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANALGESICA Y ANTI-INFLAMATORIA.
ES513560A 1981-06-30 1982-06-28 Un procedimiento para la preparacion de acidos benzoxepino 4,3-b)pirrol-2-aceticos sustituidos. Granted ES513560A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27914081A 1981-06-30 1981-06-30
US06/329,842 US4380645A (en) 1981-12-11 1981-12-11 Process for preparing Benzoxepino- or Benzthiapino[4,3-b]pyrrole-2-acetic acids

Publications (2)

Publication Number Publication Date
ES8308885A1 true ES8308885A1 (es) 1983-10-01
ES513560A0 ES513560A0 (es) 1983-10-01

Family

ID=26959474

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513560A Granted ES513560A0 (es) 1981-06-30 1982-06-28 Un procedimiento para la preparacion de acidos benzoxepino 4,3-b)pirrol-2-aceticos sustituidos.

Country Status (10)

Country Link
EP (1) EP0068460A1 (es)
KR (1) KR840000555A (es)
AU (1) AU8509882A (es)
CA (1) CA1185971A (es)
DK (1) DK291382A (es)
ES (1) ES513560A0 (es)
FI (1) FI822313A7 (es)
GR (1) GR74929B (es)
NO (1) NO822232L (es)
PT (1) PT75160A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686224A (en) * 1984-10-31 1987-08-11 Pfizer Inc. Oxindole antiinflammatory agents
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025640A (en) * 1975-08-26 1977-05-24 American Hoechst Corporation Oxothienobenzoxepin-acetic acids, precursors and derivatives thereof
EP0024807B1 (en) * 1979-07-28 1983-11-02 Beecham Group Plc Benzocycloheptapyrrolealkanoic acids and their derivatives, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DK291382A (da) 1982-12-31
EP0068460A1 (en) 1983-01-05
FI822313L (fi) 1982-12-31
NO822232L (no) 1983-01-03
FI822313A7 (fi) 1982-12-31
AU8509882A (en) 1983-01-06
GR74929B (es) 1984-07-12
PT75160A (en) 1982-07-01
KR840000555A (ko) 1984-02-25
FI822313A0 (fi) 1982-06-29
CA1185971A (en) 1985-04-23
ES513560A0 (es) 1983-10-01

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506