ES8105997A1 - Un procedimiento para la preparacion de fenil-quinolicidinas - Google Patents
Un procedimiento para la preparacion de fenil-quinolicidinasInfo
- Publication number
- ES8105997A1 ES8105997A1 ES493198A ES493198A ES8105997A1 ES 8105997 A1 ES8105997 A1 ES 8105997A1 ES 493198 A ES493198 A ES 493198A ES 493198 A ES493198 A ES 493198A ES 8105997 A1 ES8105997 A1 ES 8105997A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- procedure
- raised
- delta
- double link
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DEL RACEMATO O DE LOS ENANTIOMEROS, ASI COMO DE SALES DE ADICION DE ACIDO DE FENILQUINOLICIDINAS DE FORMULA (I), EN LA QUE X, Y Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA ADICION DE AGUA AL DOBLE ENLACE DELTA ELEVADO A 1 Y DELTA ELEVADO A 2 DE UN COMPUESTO DE FORMULA (II), EN LA QUE X, Y Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y LA LINEA DISCONTINUA INDICA UN DOBLE ENLACE EN LA POSICION 1, 2 1, 3. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN AGENTE HIDRATANTE TAL COMO EL ACIDO SULFURICO. A PARTIR DE LA MEZCLA DIASTEREOMERICA OBTENIDA SE PUEDEN SEPARAR LOS CORRESPONDIENTES DIASTEREOMEROS Y OBTENER LAS SALES POR METODOS CONOCIDOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD NEUROLEPTICA, DEPRESEIVA DEL SISTEMA NERVIOSO CENTRAL, TRANQUILIZANTE Y ANALGESICA. *FORMULA*
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1065478 | 1978-10-13 | ||
| CH715679 | 1979-08-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8105997A1 true ES8105997A1 (es) | 1981-07-01 |
| ES493198A0 ES493198A0 (es) | 1981-07-01 |
Family
ID=25700857
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484930A Expired ES8200680A1 (es) | 1978-10-13 | 1979-10-11 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493204A Granted ES493204A0 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493195A Expired ES8105991A1 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493202A Expired ES8105993A1 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493198A Granted ES493198A0 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493199A Granted ES493199A0 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493196A Granted ES493196A0 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484930A Expired ES8200680A1 (es) | 1978-10-13 | 1979-10-11 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493204A Granted ES493204A0 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493195A Expired ES8105991A1 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493202A Expired ES8105993A1 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493199A Granted ES493199A0 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
| ES493196A Granted ES493196A0 (es) | 1978-10-13 | 1980-07-08 | Un procedimiento para la preparacion de fenil-quinolicidinas |
Country Status (22)
| Country | Link |
|---|---|
| US (6) | US4236010A (es) |
| EP (2) | EP0044573B1 (es) |
| AR (3) | AR230446A1 (es) |
| AT (1) | ATE877T1 (es) |
| AU (1) | AU533075B2 (es) |
| BR (1) | BR7906543A (es) |
| CA (1) | CA1140927A (es) |
| CS (2) | CS613879A2 (es) |
| CU (1) | CU35149A (es) |
| DE (2) | DE2966740D1 (es) |
| DK (1) | DK433779A (es) |
| ES (7) | ES8200680A1 (es) |
| FI (2) | FI66611C (es) |
| GR (1) | GR73144B (es) |
| HU (1) | HU180249B (es) |
| IE (1) | IE49082B1 (es) |
| IL (1) | IL58415A (es) |
| MC (1) | MC1289A1 (es) |
| NO (1) | NO152787C (es) |
| NZ (1) | NZ191763A (es) |
| PH (1) | PH16131A (es) |
| PT (1) | PT70309A (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ191763A (en) * | 1978-10-13 | 1984-05-31 | Hoffmann La Roche | 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions |
| DK116181A (da) * | 1980-04-11 | 1981-10-12 | Hoffmann La Roche | Fremgangsmaade til fremstilling af quinolizidinderivater |
| US4889848A (en) * | 1984-11-06 | 1989-12-26 | Hoffmann-La Roche Inc. | Tricyclic pyridine derivatives |
| ZW17385A1 (en) * | 1984-11-06 | 1986-02-19 | Hoffmann La Roche | Tricyclic pyridine derivatives |
| CA1317945C (en) * | 1985-12-13 | 1993-05-18 | Ulf Fischer | Tricyclic pyridazopyridone derivatives |
| DE3614005A1 (de) * | 1986-04-25 | 1987-10-29 | Westfael Elekt Werke | Verfahren zur rauchgasentschwefelung |
| EP0294599A3 (de) * | 1987-06-12 | 1990-05-09 | F. Hoffmann-La Roche Ag | Tricyclische Pyridonderivate |
| US6992090B2 (en) * | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
| US20100311782A1 (en) * | 2009-06-08 | 2010-12-09 | Adolor Corporation | Substituted piperidinylpropanoic acid compounds and methods of their use |
| US8143273B2 (en) * | 2010-06-22 | 2012-03-27 | Hoffman-La Roche Inc. | Quinolizidine and indolizidine derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3031454A (en) * | 1962-04-24 | Hexahydro quinolizeses | ||
| CA668487A (en) * | 1963-08-13 | H. Tilford Charles | Hexahydro quinolizines | |
| GB1096589A (en) * | 1964-03-31 | 1967-12-29 | Chugai Pharmaceutical Co Ltd | Novel quinolizidine derivatives or salts thereof and process for preparing the same |
| DE1470084A1 (de) * | 1964-08-19 | 1969-05-29 | Merck Ag E | Verfahren zur Herstellung von substituierten Piperidin-derivaten |
| US3394141A (en) * | 1965-11-12 | 1968-07-23 | Fabio Sparatore | Z-benzyaminobenzimidazoles |
| US3852452A (en) * | 1970-02-10 | 1974-12-03 | Ayerst Mckenna & Harrison | Benzocycloheptaisoquinoline derivatives as cns depressants |
| NZ191763A (en) * | 1978-10-13 | 1984-05-31 | Hoffmann La Roche | 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions |
-
1979
- 1979-10-05 NZ NZ191763A patent/NZ191763A/en unknown
- 1979-10-05 MC MC791408A patent/MC1289A1/fr unknown
- 1979-10-08 IL IL58415A patent/IL58415A/xx unknown
- 1979-10-08 AU AU51545/79A patent/AU533075B2/en not_active Ceased
- 1979-10-09 CA CA000337172A patent/CA1140927A/en not_active Expired
- 1979-10-09 CS CS796861A patent/CS613879A2/cs unknown
- 1979-10-10 PH PH23149A patent/PH16131A/en unknown
- 1979-10-10 HU HU79HO2187A patent/HU180249B/hu unknown
- 1979-10-11 EP EP81106675A patent/EP0044573B1/de not_active Expired
- 1979-10-11 DE DE8181106675T patent/DE2966740D1/de not_active Expired
- 1979-10-11 CU CU7935149A patent/CU35149A/es unknown
- 1979-10-11 ES ES484930A patent/ES8200680A1/es not_active Expired
- 1979-10-11 AT AT79103907T patent/ATE877T1/de not_active IP Right Cessation
- 1979-10-11 GR GR60236A patent/GR73144B/el unknown
- 1979-10-11 EP EP79103907A patent/EP0012170B1/de not_active Expired
- 1979-10-11 DE DE7979103907T patent/DE2962580D1/de not_active Expired
- 1979-10-12 DK DK433779A patent/DK433779A/da not_active Application Discontinuation
- 1979-10-12 BR BR7906543A patent/BR7906543A/pt unknown
- 1979-10-12 FI FI793182A patent/FI66611C/fi not_active IP Right Cessation
- 1979-10-12 PT PT70309A patent/PT70309A/pt unknown
- 1979-10-12 NO NO793300A patent/NO152787C/no unknown
- 1979-10-12 IE IE1943/79A patent/IE49082B1/en unknown
- 1979-10-15 US US06/085,096 patent/US4236010A/en not_active Expired - Lifetime
-
1980
- 1980-05-12 US US06/148,646 patent/US4272627A/en not_active Expired - Lifetime
- 1980-07-08 ES ES493204A patent/ES493204A0/es active Granted
- 1980-07-08 ES ES493195A patent/ES8105991A1/es not_active Expired
- 1980-07-08 ES ES493202A patent/ES8105993A1/es not_active Expired
- 1980-07-08 ES ES493198A patent/ES493198A0/es active Granted
- 1980-07-08 ES ES493199A patent/ES493199A0/es active Granted
- 1980-07-08 ES ES493196A patent/ES493196A0/es active Granted
- 1980-12-18 US US06/217,864 patent/US4338444A/en not_active Expired - Fee Related
- 1980-12-18 US US06/217,887 patent/US4329467A/en not_active Expired - Fee Related
- 1980-12-18 US US06/217,863 patent/US4306067A/en not_active Expired - Fee Related
- 1980-12-18 US US06/217,888 patent/US4316030A/en not_active Expired - Fee Related
-
1981
- 1981-02-20 AR AR284380A patent/AR230446A1/es active
- 1981-02-20 AR AR284384A patent/AR230637A1/es active
- 1981-02-20 AR AR284379A patent/AR230636A1/es active
-
1984
- 1984-04-05 FI FI841359A patent/FI70017C/fi not_active IP Right Cessation
- 1984-08-13 CS CS846138A patent/CS241050B2/cs unknown
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