ES8400449A1 - Procedimiento para la preparacion de 10-(1,2-propadienil)es-teroides - Google Patents

Procedimiento para la preparacion de 10-(1,2-propadienil)es-teroides

Info

Publication number
ES8400449A1
ES8400449A1 ES503451A ES503451A ES8400449A1 ES 8400449 A1 ES8400449 A1 ES 8400449A1 ES 503451 A ES503451 A ES 503451A ES 503451 A ES503451 A ES 503451A ES 8400449 A1 ES8400449 A1 ES 8400449A1
Authority
ES
Spain
Prior art keywords
procedure
compound
preparation
insaturation
lithium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503451A
Other languages
English (en)
Other versions
ES503451A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES503451A0 publication Critical patent/ES503451A0/es
Publication of ES8400449A1 publication Critical patent/ES8400449A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 10-(1,2-PROPADIENIL) ESTEROIDES.CONSISTE EN SOMETER UN COMPUESTO DE HIDROZIPROPINILO (II) O (III) A UN PROCEDIMIENTO SELECCIONADO ENTRE: A) CONVERSION AL ACETATO CON ANHIDRIDO ACETICO SEGUIDO DE TRATAMIENTO CON LITIO-ALQUINILO-ALQUIL -COBRE O LITIO-DIMETIL COBRE TRASLADANDO A CONTINUACION CUALQUIER INSATURACION 5 A LA POSICION 4. B) OPCIONALMENTE, TRATAR EL PRODUCTO OBTENIDO (I) CON UN AGENTE DE DESHIDROGENACION PARA INTRODUCIR UNA INSATURACION EN EL NUCLEO DE ESTEROIDE. C) OPCIONALMENTE REDUCIR EL COMPUESTO PARA DAR EL COMPUESTO 17B-HIDROXI O TRATARLOCON UN DERIVADO ACIDO PARA DAR EL CORRESPONDIENTE 17B-ESTER.INHIBIDORES IRREVERSIBLES DE ENZIMAS DE AROMATASA.
ES503451A 1980-06-27 1981-06-26 Procedimiento para la preparacion de 10-(1,2-propadienil)es-teroides Expired ES8400449A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/163,453 US4289762A (en) 1980-06-27 1980-06-27 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors

Publications (2)

Publication Number Publication Date
ES503451A0 ES503451A0 (es) 1983-11-01
ES8400449A1 true ES8400449A1 (es) 1983-11-01

Family

ID=22590073

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503451A Expired ES8400449A1 (es) 1980-06-27 1981-06-26 Procedimiento para la preparacion de 10-(1,2-propadienil)es-teroides

Country Status (21)

Country Link
US (1) US4289762A (es)
JP (1) JPS5738798A (es)
AT (1) AT377989B (es)
AU (1) AU539215B2 (es)
BE (1) BE889404A (es)
CA (1) CA1173432A (es)
CH (1) CH647532A5 (es)
DE (1) DE3124719C2 (es)
DK (1) DK163129C (es)
ES (1) ES8400449A1 (es)
FR (1) FR2485544A1 (es)
GB (1) GB2078750B (es)
IE (1) IE51352B1 (es)
IL (1) IL63142A0 (es)
IT (1) IT1171340B (es)
NL (1) NL8103098A (es)
NO (1) NO156694C (es)
NZ (1) NZ197495A (es)
PH (1) PH16690A (es)
SE (1) SE448878B (es)
ZA (1) ZA814219B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3362176D1 (en) * 1982-07-14 1986-03-27 Akzo Nv Novel 19-thio-androstane derivatives
US4495102A (en) * 1982-09-03 1985-01-22 G. D. Searle & Co. Aminoalkyl steroids
EP0114033B1 (de) * 1982-12-21 1988-10-12 Ciba-Geigy Ag Substituierte Azabicycloalkane, ihre Verwendung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verfahren zur Herstellung dieser Verbindungen
DE3323321A1 (de) * 1983-06-24 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels
US4634694A (en) * 1984-01-14 1987-01-06 Akzo N.V. Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives
GB8531747D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynylestrene derivatives
GB8624251D0 (en) * 1986-10-09 1986-11-12 Erba Farmitalia "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3705990A1 (de) * 1987-02-20 1988-09-01 Schering Ag 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3714965A1 (de) * 1987-04-30 1988-11-10 Schering Ag 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4910191A (en) * 1988-06-28 1990-03-20 Merrell Dow Pharmaceuticals Inc. 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4435368A1 (de) * 1994-09-22 1996-03-28 Schering Ag Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
JP3446209B2 (ja) 1995-02-01 2003-09-16 セイコーエプソン株式会社 液晶表示装置、液晶表示装置の駆動方法、および液晶表示装置の検査方法
SK14252003A3 (sk) * 2001-04-17 2004-03-02 Ares Trading S. A. Použitie aromatázového inhibítora, farmaceutický prostriedok s obsahom aromatázového inhibítora a farmaceutické balenie
DE10141937A1 (de) * 2001-08-28 2003-03-27 Alfred Schmidt Markierung der Aromatase
EP1854465A1 (en) 2006-05-12 2007-11-14 Alexander Tobias Teichmann Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers
AU2011237592B2 (en) 2010-04-08 2016-10-27 Emory University Substituted androst-4-ene diones
EP3666276A1 (en) 2018-12-14 2020-06-17 dcic Biopharmaceutical Limited Medication against estrogen-receptor beta (erbeta) positive breast tumor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3102127A (en) * 1962-06-12 1963-08-27 Syntex Corp 19-methylene-androstane derivatives
FR1519387A (fr) * 1966-04-20 1968-03-29 Hoffmann La Roche Procédé pour la préparation de 19-alcényl-stéroïdes
DE2310963A1 (de) * 1972-04-14 1974-09-05 Schering Ag Methode zur kontrazeption durch verabfolgung von stufenkombinationspraeparaten
CH606101A5 (es) * 1975-01-30 1978-10-13 Ciba Geigy Ag

Also Published As

Publication number Publication date
DK163129C (da) 1992-06-09
CA1173432A (en) 1984-08-28
BE889404A (fr) 1981-12-28
DK284481A (da) 1981-12-28
PH16690A (en) 1984-01-06
ES503451A0 (es) 1983-11-01
IE51352B1 (en) 1986-12-10
FR2485544B1 (es) 1983-12-16
IT8148781A1 (it) 1982-12-26
IT1171340B (it) 1987-06-10
IE811435L (en) 1981-12-27
DK163129B (da) 1992-01-20
US4289762A (en) 1981-09-15
GB2078750A (en) 1982-01-13
ATA285881A (de) 1984-10-15
AT377989B (de) 1985-05-28
NO812509L (no) 1983-01-24
AU539215B2 (en) 1984-09-13
IL63142A0 (en) 1981-09-13
JPS5738798A (en) 1982-03-03
NO156694C (no) 1987-11-04
AU7236981A (en) 1982-01-07
JPH0121158B2 (es) 1989-04-19
DE3124719A1 (de) 1982-03-18
SE8103988L (sv) 1981-12-28
NL8103098A (nl) 1982-01-18
NO156694B (no) 1987-07-27
SE448878B (sv) 1987-03-23
DE3124719C2 (de) 1994-03-03
NZ197495A (en) 1985-01-31
IT8148781A0 (it) 1981-06-26
CH647532A5 (de) 1985-01-31
GB2078750B (en) 1984-08-22
FR2485544A1 (fr) 1981-12-31
ZA814219B (en) 1982-07-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519