ES8400603A1 - Un procedimiento para la determinacion cuantitativa del factor xii de coagulacion de la sangre en el plasma sanguineo humano. - Google Patents

Un procedimiento para la determinacion cuantitativa del factor xii de coagulacion de la sangre en el plasma sanguineo humano.

Info

Publication number
ES8400603A1
ES8400603A1 ES516987A ES516987A ES8400603A1 ES 8400603 A1 ES8400603 A1 ES 8400603A1 ES 516987 A ES516987 A ES 516987A ES 516987 A ES516987 A ES 516987A ES 8400603 A1 ES8400603 A1 ES 8400603A1
Authority
ES
Spain
Prior art keywords
factor xii
human plasma
blood clotting
quantitative determination
clotting factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516987A
Other languages
English (en)
Other versions
ES516987A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Nutritional Products AG
Original Assignee
Pentapharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm AG filed Critical Pentapharm AG
Publication of ES516987A0 publication Critical patent/ES516987A0/es
Publication of ES8400603A1 publication Critical patent/ES8400603A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96458—Factor XII (3.4.21.38)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA DETERMINACION CUANTITATIVA DEL FACTOR DE COAGULACION XII DE LA SANGRE EN EL PLASMA SANGUINEO HUMANO.CONSISTE EN TRATAR EL PLASMA CON UN ACTIVADOR PARA TRANSFORMAR EL FACTOR XII, CONTENIDO EN EL PLASMA, EN FACTOR XIIA. PARA ELLO SE HACE REACCIONAR EL PLASMA CON UN DERIVADO DE TRIPEPTIDO, DE FORMULA GENERAL (I), EN LA QUE R1 REPRESENTA UN GRUPO AMINO SUSTITUIDO CROMOGENO O FLUOROGENO; R2 Y R3 REPRESENTAN CONJUNTAMENTE UN RADICAL ALCOHILENO CON 3 A 4 ATOMOS DE CARBONO; R4 REPRESENTA HIDROGENO; Y R5 TIENE EL MISMO SIGNIFICADO QUE R3.
ES516987A 1981-11-02 1982-10-29 Un procedimiento para la determinacion cuantitativa del factor xii de coagulacion de la sangre en el plasma sanguineo humano. Expired ES8400603A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH697281 1981-11-02

Publications (2)

Publication Number Publication Date
ES516987A0 ES516987A0 (es) 1983-10-16
ES8400603A1 true ES8400603A1 (es) 1983-10-16

Family

ID=4317925

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516987A Expired ES8400603A1 (es) 1981-11-02 1982-10-29 Un procedimiento para la determinacion cuantitativa del factor xii de coagulacion de la sangre en el plasma sanguineo humano.

Country Status (9)

Country Link
US (1) US4598043A (es)
EP (1) EP0078764B1 (es)
JP (1) JPS5886100A (es)
AT (1) ATE17262T1 (es)
CA (1) CA1184837A (es)
DE (1) DE3268329D1 (es)
DK (1) DK156668C (es)
ES (1) ES8400603A1 (es)
NO (1) NO823619L (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882272A (en) * 1986-10-01 1989-11-21 Temple University - Of The Commonwealth System Of Higher Education High molecular weight kininogen assay
JP3213831B2 (ja) * 1993-08-06 2001-10-02 日本臓器製薬株式会社 被検物質の活性測定方法
JP3213832B2 (ja) * 1993-08-06 2001-10-02 日本臓器製薬株式会社 被検物質の活性測定法
US6913900B2 (en) * 2001-08-29 2005-07-05 Nippon Zoki Pharmaceutical Co., Ltd. Plasma prekallikrein activation and kallikrein production assay
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
EP1573339A2 (en) * 2002-12-20 2005-09-14 Axis-Shield Diagnostics Limited Detection or determination of variants of factor xiia
DE102005003145B4 (de) * 2005-01-21 2006-10-19 Dade Behring Marburg Gmbh Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
US20070166344A1 (en) * 2006-01-18 2007-07-19 Xin Qu Non-leaching surface-active film compositions for microbial adhesion prevention
GB0607515D0 (en) * 2006-04-13 2006-05-24 Axis Shield Diagnostics Ltd Anti-factor xlla therapy
EP2333555A1 (de) * 2009-12-09 2011-06-15 Siemens Healthcare Diagnostics Products GmbH Heterogener Gerinnungstest
EP2465941A1 (de) 2010-12-20 2012-06-20 Siemens Healthcare Diagnostics Products GmbH Verfahren zur simultanen Bestimmung mehrerer Gerinnungsproteasen
EP3198272B1 (en) 2014-09-26 2022-04-06 Abbott Point Of Care, Inc. Cartridge device identification for coagulation assays in fluid samples
US10048282B2 (en) 2014-09-26 2018-08-14 Abbott Point Of Care Inc. Cartridge device with fluidic junctions for coagulation assays in fluid samples
CN107110874B (zh) 2014-09-26 2019-06-04 雅培医护站股份有限公司 用于测定流体样品中的凝固的传感器
EP3954457A3 (en) 2014-09-26 2022-05-18 Abbott Point Of Care Inc Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples
CN106999930B (zh) 2014-09-26 2020-09-08 雅培医护站股份有限公司 用于测定流体样本中的凝结的具有分段射流的盒设备
WO2016049557A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Ellagic acid formulations for use in coagulation assays
US10114031B2 (en) 2014-09-26 2018-10-30 Abbott Point Of Care Inc. Single channel cartridge device for coagulation assays in fluid samples

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4137225A (en) * 1975-07-11 1979-01-30 Ab Kabi Novel chromogenic enzyme substrates
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4169015A (en) * 1975-07-11 1979-09-25 Ab Kabi Novel chromogenic thrombin substrates
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
US4302538A (en) * 1978-03-27 1981-11-24 Ortho Diagnostics Inc. Buffer system in an anti-thrombin III test
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
EP0018002B1 (de) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Neues Bestimmungsverfahren für Proteasen und Antiproteasen

Also Published As

Publication number Publication date
JPS5886100A (ja) 1983-05-23
DK484682A (da) 1983-05-03
CA1184837A (en) 1985-04-02
DE3268329D1 (en) 1986-02-13
ATE17262T1 (de) 1986-01-15
ES516987A0 (es) 1983-10-16
JPH0346119B2 (es) 1991-07-15
DK156668B (da) 1989-09-18
DK156668C (da) 1990-02-12
EP0078764A1 (de) 1983-05-11
EP0078764B1 (de) 1986-01-02
US4598043A (en) 1986-07-01
NO823619L (no) 1983-05-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601