ES8400746A1 - Procedimiento de obtencion de un ester del acido apovincami-nico - Google Patents
Procedimiento de obtencion de un ester del acido apovincami-nicoInfo
- Publication number
- ES8400746A1 ES8400746A1 ES506309A ES506309A ES8400746A1 ES 8400746 A1 ES8400746 A1 ES 8400746A1 ES 506309 A ES506309 A ES 506309A ES 506309 A ES506309 A ES 506309A ES 8400746 A1 ES8400746 A1 ES 8400746A1
- Authority
- ES
- Spain
- Prior art keywords
- acid ester
- apovincaminic acid
- prepn
- ester prepn
- alkaline medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Apovincaminic acid ester Chemical class 0.000 title 1
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 1
- DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 abstract 1
- UXMCFEBDJVHVNH-HOJAQTOUSA-N ac1l52id Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(O)=O)N5C2=C1 UXMCFEBDJVHVNH-HOJAQTOUSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 abstract 1
- XRMLLVHAALNSGZ-HJNYFJLDSA-N ethylvincaminate Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@@](C(=O)OCC)(O)N5C2=C1 XRMLLVHAALNSGZ-HJNYFJLDSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960002726 vincamine Drugs 0.000 abstract 1
- 229960000744 vinpocetine Drugs 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE UN ESTER DEL ACIDO APOVINCAMINICO.SE EFECTUAN LAS SIGUIENTES OPERACIONES: 1.O)OBTENCION DEL ACIDO VINCAMINICO POR HIDROLISIS DE LA VINCAMINA EN MEDIO ALCALINO. 2.O)REACCION DEL ACIDO VINCAMINICO CON BROMURO DE ETILO EN MEDIO ALCALINO CON LO QUE SE OBTIENE EL VINCAMINATO DE ETILO. 3.O)DESHIDRATACION DEL VINCAMINATO OBTENIDO EN PRESENCIA DE DIMETILSULFOXIDO CON LO QUE SE OBTIENE EL APOVINCAMINATO DE ETILO (I).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES506309A ES506309A0 (es) | 1981-10-16 | 1981-10-16 | Procedimiento de obtencion de un ester del acido apovincami-nico |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES506309A ES506309A0 (es) | 1981-10-16 | 1981-10-16 | Procedimiento de obtencion de un ester del acido apovincami-nico |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8400746A1 true ES8400746A1 (es) | 1983-11-01 |
| ES506309A0 ES506309A0 (es) | 1983-11-01 |
Family
ID=8483088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES506309A Granted ES506309A0 (es) | 1981-10-16 | 1981-10-16 | Procedimiento de obtencion de un ester del acido apovincami-nico |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES506309A0 (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2052449A1 (es) * | 1992-12-22 | 1994-07-01 | Covex Sa | Nuevo procedimiento para la preparacion del apovincaminato de etilo. |
| CN104230921A (zh) * | 2014-09-16 | 2014-12-24 | 东北制药集团股份有限公司 | 一种长春胺乙酯的制备方法 |
-
1981
- 1981-10-16 ES ES506309A patent/ES506309A0/es active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2052449A1 (es) * | 1992-12-22 | 1994-07-01 | Covex Sa | Nuevo procedimiento para la preparacion del apovincaminato de etilo. |
| CN104230921A (zh) * | 2014-09-16 | 2014-12-24 | 东北制药集团股份有限公司 | 一种长春胺乙酯的制备方法 |
| CN104230921B (zh) * | 2014-09-16 | 2017-01-11 | 东北制药集团股份有限公司 | 一种长春胺乙酯的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES506309A0 (es) | 1983-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |