JPS5479247A - Para-substituted phenylacetic acid derivative and its preparation - Google Patents
Para-substituted phenylacetic acid derivative and its preparationInfo
- Publication number
- JPS5479247A JPS5479247A JP14660677A JP14660677A JPS5479247A JP S5479247 A JPS5479247 A JP S5479247A JP 14660677 A JP14660677 A JP 14660677A JP 14660677 A JP14660677 A JP 14660677A JP S5479247 A JPS5479247 A JP S5479247A
- Authority
- JP
- Japan
- Prior art keywords
- phenylacetic acid
- para
- preparation
- formula
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- GJNNLILROAPGRC-UHFFFAOYSA-N 2-[4-(chloromethyl)phenyl]acetic acid Chemical compound OC(=O)CC1=CC=C(CCl)C=C1 GJNNLILROAPGRC-UHFFFAOYSA-N 0.000 abstract 1
- JDMCKJTWYFQOHD-UHFFFAOYSA-N 2-[4-(methylsulfanylmethyl)phenyl]acetic acid Chemical compound CSCC1=CC=C(CC(O)=O)C=C1 JDMCKJTWYFQOHD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001356 alkyl thiols Chemical class 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 238000005341 cation exchange Methods 0.000 abstract 1
- 150000001767 cationic compounds Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000007265 chloromethylation reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000002892 organic cations Chemical class 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229960003424 phenylacetic acid Drugs 0.000 abstract 1
- 239000003279 phenylacetic acid Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:Para-substituted phenylacetic acid derivatives of formulaI(R1 is lower alkyl; R2 is H, lower alkyl; R3 is H, lower alkyl, inorganic or organic cation; n is 0W2).
EXAMPLE: p-Methylthiomethylphenylacetic acid.
USE: Antiflammatory agents and antithrombotic agents.
PREPARATION: The reaction of p-chloromethylphenylacetic acid of formula II (R31 is R3) with an alkylthiol of formula: R1SH (R1 is preferably 1W10C alkyl) is effected in an alkaline medium, then the reaction product is subjected to hydrolysis, cation exchange, and oxidation to yield the compound of formulaI. The compound of formula II is prepared by chloromethylation of phenylacetic acid or its ester.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14660677A JPS5479247A (en) | 1977-12-08 | 1977-12-08 | Para-substituted phenylacetic acid derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14660677A JPS5479247A (en) | 1977-12-08 | 1977-12-08 | Para-substituted phenylacetic acid derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5479247A true JPS5479247A (en) | 1979-06-25 |
| JPS5542984B2 JPS5542984B2 (en) | 1980-11-04 |
Family
ID=15411523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14660677A Granted JPS5479247A (en) | 1977-12-08 | 1977-12-08 | Para-substituted phenylacetic acid derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5479247A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002020366A (en) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | Method for producing alkylthiophenylacetic acid |
-
1977
- 1977-12-08 JP JP14660677A patent/JPS5479247A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002020366A (en) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | Method for producing alkylthiophenylacetic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5542984B2 (en) | 1980-11-04 |
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