ES8401009A1 - Procedimiento para la preparacion de 2-(p-isobutil-fenil)propionato de 2-hidroxi-3-(o-metoxi-fenoxi)propilo. - Google Patents

Procedimiento para la preparacion de 2-(p-isobutil-fenil)propionato de 2-hidroxi-3-(o-metoxi-fenoxi)propilo.

Info

Publication number
ES8401009A1
ES8401009A1 ES517685A ES517685A ES8401009A1 ES 8401009 A1 ES8401009 A1 ES 8401009A1 ES 517685 A ES517685 A ES 517685A ES 517685 A ES517685 A ES 517685A ES 8401009 A1 ES8401009 A1 ES 8401009A1
Authority
ES
Spain
Prior art keywords
phenoxy
propionate
isobutyl
methoxy
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517685A
Other languages
English (en)
Other versions
ES517685A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ausonia Farmaceutici SRL
Original Assignee
Ausonia Farmaceutici SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ausonia Farmaceutici SRL filed Critical Ausonia Farmaceutici SRL
Publication of ES8401009A1 publication Critical patent/ES8401009A1/es
Publication of ES517685A0 publication Critical patent/ES517685A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2-(P-ISOBUTILFENIL)-PROPIONATO DE 2-HIDROXI-3-(O-METOXI-F ENOXI) PROPILO.SE HACE REACCIONAR EL CLORURO DEL ACIDO 2-(P-ISOBUTIL-FENIL)-PROPIONICO DE FORMULA (II) CON 3-(O-METOXI-FENOXI)-PROPANDIOL DE FORMULA (III) EN UN DISOLVENTE INERTE PARA OBTENER 2-(-P-ISOBUTIL-FENIL)-PROPIONATO DE 2-HIDROXI-3-(O-METOXI-FENOXI)PROPILO DE FORMULA (I). LA REACCION SE VERIFICA A TEMPERATURA COMPRENDIDAS ENTRE 0 Y 60JC, PREFERIBLEMENTE A TEMPERATURA AMBIENTE. SE ACTUA, PREFERIBLEMENTE EN DISOLVENTES APROTICOS, COMO DICLOROMETANO, TETRAHIDROFURANO, DIETILETER Y EN PRESENCIA DE ACEPTORESDE ACIDEZ, COMO PIRIDINA O TRIETILAMINA.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANALGESICOS, ANTIINFLAMATORIOS, ANTIPIRETICOS Y MUCORREGULADORES.
ES517685A 1982-03-10 1982-11-25 Procedimiento para la preparacion de 2-(p-isobutil-fenil)propionato de 2-hidroxi-3-(o-metoxi-fenoxi)propilo. Granted ES517685A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20073/82A IT1190727B (it) 1982-03-10 1982-03-10 Composto ad attivita' analgesica,antiinfiammatoria e mucoregolatrice procedimento per la sua preparazione e relative composizioni farmaceutiche

Publications (2)

Publication Number Publication Date
ES8401009A1 true ES8401009A1 (es) 1983-12-16
ES517685A0 ES517685A0 (es) 1983-12-16

Family

ID=11163583

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517685A Granted ES517685A0 (es) 1982-03-10 1982-11-25 Procedimiento para la preparacion de 2-(p-isobutil-fenil)propionato de 2-hidroxi-3-(o-metoxi-fenoxi)propilo.

Country Status (14)

Country Link
US (1) US4501914A (es)
JP (1) JPS58162554A (es)
BE (1) BE895111A (es)
CH (1) CH650491A5 (es)
DE (1) DE3242961C2 (es)
ES (1) ES517685A0 (es)
FR (1) FR2523124B1 (es)
GB (1) GB2116541B (es)
GR (1) GR77030B (es)
IT (1) IT1190727B (es)
LU (1) LU84486A1 (es)
NL (1) NL8204626A (es)
PT (1) PT75894B (es)
ZA (1) ZA827898B (es)

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IT1212840B (it) * 1983-11-28 1989-11-30 Zambeletti Spa L Derivati di acidi bifenililalcanoici, loro preparazione e composizioni farmaceutiche che licontengono.
US9303038B2 (en) 2011-09-06 2016-04-05 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological diseases
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US20150133533A1 (en) * 2012-05-08 2015-05-14 Mahesh Kandula Compositions and methods for the treatment of cough
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US9573927B2 (en) 2012-05-10 2017-02-21 Cellix Bio Private Limited Compositions and methods for the treatment of severe pain
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
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JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
US9434729B2 (en) 2012-05-23 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
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US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
US9187427B2 (en) 2012-08-03 2015-11-17 Cellix Bio Private Limited N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases
WO2014037833A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment inflammation and lipid disorders
AU2013311349A1 (en) 2012-09-08 2014-11-27 Cellixbio Private Limited Compositions and methods for treatment of inflammation and lipid disorders
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
AU2014276346A1 (en) 2013-06-04 2015-12-24 Cellixbio Private Limited Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
SG11201706952VA (en) 2014-09-26 2017-10-30 Cellix Bio Private Ltd Compositions and methods for the treatment of epilepsy and neurological disorders
EP3201168B1 (en) 2014-09-29 2020-03-18 Cellix Bio Private Limited Compounds and compositions for the treatment of multiple sclerosis
AU2014414316B2 (en) 2014-10-27 2020-04-09 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
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US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
WO2016088132A1 (en) 2014-12-01 2016-06-09 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
JP6679616B2 (ja) 2015-01-06 2020-04-22 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ 炎症及び疼痛の治療のための組成物及び方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150137A (en) * 1975-12-24 1979-04-17 Hisamitsu Pharmaceutical Co. Inc. Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use
IT1064751B (it) * 1976-07-09 1985-02-25 Acraf P. isobutil idratropato di guaiacolo

Also Published As

Publication number Publication date
JPS58162554A (ja) 1983-09-27
IT8220073A0 (it) 1982-03-10
JPH0121139B2 (es) 1989-04-19
DE3242961A1 (de) 1983-09-15
GB2116541A (en) 1983-09-28
FR2523124A1 (fr) 1983-09-16
IT1190727B (it) 1988-02-24
DE3242961C2 (de) 1984-05-10
FR2523124B1 (fr) 1985-07-19
LU84486A1 (fr) 1983-06-13
PT75894A (en) 1982-12-01
NL8204626A (nl) 1983-10-03
CH650491A5 (it) 1985-07-31
GR77030B (es) 1984-09-04
US4501914A (en) 1985-02-26
BE895111A (nl) 1983-03-16
ZA827898B (en) 1983-08-31
ES517685A0 (es) 1983-12-16
PT75894B (en) 1986-01-15
GB2116541B (en) 1985-10-02

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