ES8401072A1 - Procedimiento de preparacion de un nuevo espirodecano. - Google Patents

Procedimiento de preparacion de un nuevo espirodecano.

Info

Publication number
ES8401072A1
ES8401072A1 ES517622A ES517622A ES8401072A1 ES 8401072 A1 ES8401072 A1 ES 8401072A1 ES 517622 A ES517622 A ES 517622A ES 517622 A ES517622 A ES 517622A ES 8401072 A1 ES8401072 A1 ES 8401072A1
Authority
ES
Spain
Prior art keywords
dioxopurine
diazaspiro
decan
oxa
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517622A
Other languages
English (en)
Other versions
ES517622A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Faes Farma SA
Original Assignee
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA filed Critical Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority to ES517622A priority Critical patent/ES8401072A1/es
Priority to BE0/211883A priority patent/BE898234A/fr
Priority to US06/552,481 priority patent/US4584372A/en
Priority to CH6264/83A priority patent/CH656620A5/de
Priority to PT77702A priority patent/PT77702B/pt
Priority to GB08331068A priority patent/GB2130586B/en
Priority to JP58218818A priority patent/JPS59205386A/ja
Priority to IT23819/83A priority patent/IT1194471B/it
Priority to FR8318665A priority patent/FR2536400B1/fr
Priority to DE19833342325 priority patent/DE3342325A1/de
Publication of ES517622A0 publication Critical patent/ES517622A0/es
Publication of ES8401072A1 publication Critical patent/ES8401072A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UN NUEVO ESPIRODECANO.CONSISTE EN LA REACCION, A UNA TEMPERATURA COMPRENDIDA ENTRE 10 Y 130JC, DE UN DERIVADO REACTIVO DEL ACIDO 1, 2, 3, 6-TETRAHIDRO-1,3-DIMETIL-2,6-DIOXOPURINA-7 -ACETICO, QUE ES EL ANHIDRIDO O UN HALURO, PREFERENTEMENTE EL CLORURO, CON LA 8-(2-FENILETIL)-1-OXA- 3,8-DIAZASPIRO4.5 DECAN-2-ONA O UNA SAL DE LA MISMA, QUE ES SU HIDROCLORURO, EN UN DISOLVENTE, QUE PUEDE SER HEXANO, BENCENO, TETRACLOROMETANO, N,N-DIMETIL FORMAMIDA, TRIETILAMINA O SUS MEZCLAS BINARIAS, OBTENIENDOSE UN NUEVO ESPIRODECANO QUE ES LA 3-(1, 2, 3, 6-TETRAHIDRO-1,3-DIMETIL-2,6-DIOXOPURINA-7-ACETIL)-8-(2-FENILETIL)-1-OXA-3,8-DIAZASPIRO 4.5 DECAN-2-ONA Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, PREFERENTEMENTE EL HIDROCLORURO, EL OXALATO Y TEONATO.DE APLICACION FARMACOLOGICA POR SU ACTIVIDAD BRONCODILATADORA Y ANTIINFLAMATORIA.
ES517622A 1982-11-23 1982-11-23 Procedimiento de preparacion de un nuevo espirodecano. Expired ES8401072A1 (es)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ES517622A ES8401072A1 (es) 1982-11-23 1982-11-23 Procedimiento de preparacion de un nuevo espirodecano.
BE0/211883A BE898234A (fr) 1982-11-23 1983-11-16 Nouveau spirodécane, sels de celui-ci et leur préparation.
US06/552,481 US4584372A (en) 1982-11-23 1983-11-16 Compound 3-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetyl-8-(2-phenylethyl)-1-oxa-3,8-diazaspiro-(4,5)decan-2-one and a process of preparation thereof
CH6264/83A CH656620A5 (de) 1982-11-23 1983-11-22 Spirodecanderivat der theophyllin-7-essigsaeure, seine herstellung und pharmazeutische zubereitungen.
PT77702A PT77702B (en) 1982-11-23 1983-11-22 Process for preparing a new spirodecane
GB08331068A GB2130586B (en) 1982-11-23 1983-11-22 3-(1,2,3,6-tetrahydro-1,3-dimethyl-2, 6-dioxopurine-7-acetyl)-8-(2-phenylethyl)-1-oxa-3,8-diazospiro(4.5) decan-2-one and its salts their preparation and pharmaceutical compositions containing them
JP58218818A JPS59205386A (ja) 1982-11-23 1983-11-22 新規なスピロデカンおよびその塩ならびにそれらの製造方法
IT23819/83A IT1194471B (it) 1982-11-23 1983-11-22 Procedimento per la preparazione di uno spirodecano e prodotto con esso ottenuto
FR8318665A FR2536400B1 (fr) 1982-11-23 1983-11-23 3-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetyl)-8-(2-phenylethyl)-1-oxa-3,8-diazaspiro (4,5) decane-2-one, utile comme bronchodilatateur ou anti-inflammatoire, et son procede de preparation
DE19833342325 DE3342325A1 (de) 1982-11-23 1983-11-23 3-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6- dioxopurin-7-acetyl)-8-(2-phenylethyl)-1-oxa-3,8-diazaspiro-(4.5)decan-2-on, verfahren zu dessen herstellung und dieses enthaltende arzneimittel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES517622A ES8401072A1 (es) 1982-11-23 1982-11-23 Procedimiento de preparacion de un nuevo espirodecano.

Publications (2)

Publication Number Publication Date
ES517622A0 ES517622A0 (es) 1983-12-16
ES8401072A1 true ES8401072A1 (es) 1983-12-16

Family

ID=8484963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517622A Expired ES8401072A1 (es) 1982-11-23 1982-11-23 Procedimiento de preparacion de un nuevo espirodecano.

Country Status (10)

Country Link
US (1) US4584372A (es)
JP (1) JPS59205386A (es)
BE (1) BE898234A (es)
CH (1) CH656620A5 (es)
DE (1) DE3342325A1 (es)
ES (1) ES8401072A1 (es)
FR (1) FR2536400B1 (es)
GB (1) GB2130586B (es)
IT (1) IT1194471B (es)
PT (1) PT77702B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
US5423598A (en) * 1993-06-11 1995-06-13 Trw Vehicle Safety Systems Inc. Safety apparatus

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127065C (es) * 1964-04-22
FR96352E (fr) * 1967-12-29 1972-06-16 Science Union & Cie Nouveaux dérives du spiro (4,5) decane et leur procédé de préparation.
GB1227365A (es) * 1968-07-29 1971-04-07
FR2036557A5 (es) * 1969-03-25 1970-12-24 Logeais Laboratoires
GB1377610A (en) * 1970-12-19 1974-12-18 Logeais Labor Jacques 5-piperidine-4-spiro- oxazolidinones method for their preparation and applications thereof
US4028351A (en) * 1971-09-07 1977-06-07 Buskine S.A. Method for the preparation of derivatives of spiro (4,5)-decane and derivatives thus obtained
CH601304A5 (es) * 1974-02-12 1978-07-14 Buskine Sa
BE790675A (fr) * 1971-10-29 1973-04-27 Science Union & Cie Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
US3935196A (en) * 1974-04-22 1976-01-27 Interx Research Corporation Useful pro-drug forms of theophylline
DE2542154C2 (de) * 1974-09-27 1986-11-06 Centre Européen de Recherches Mauvernay, Riom, Puy-de-Dôme 6-(3-Chlor)phenoxy-3-methyl-2-oxo-1-aza-4-oxa-spiro[4,5]-decan, Verfahren zu seiner Herstellung und es enthaltende Arzneimittel
GB1509409A (en) * 1976-09-30 1978-05-04 Creat Pharmaceutically active thiozolidine derivatives
US4244961A (en) * 1978-10-26 1981-01-13 Syntex (U.S.A.) Inc. 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents

Also Published As

Publication number Publication date
IT1194471B (it) 1988-09-22
PT77702A (en) 1983-12-01
BE898234A (fr) 1984-03-16
DE3342325A1 (de) 1984-05-24
ES517622A0 (es) 1983-12-16
GB2130586B (en) 1985-12-11
FR2536400A1 (fr) 1984-05-25
CH656620A5 (de) 1986-07-15
PT77702B (en) 1986-07-15
JPH041756B2 (es) 1992-01-14
JPS59205386A (ja) 1984-11-20
US4584372A (en) 1986-04-22
GB8331068D0 (en) 1983-12-29
IT8323819A0 (it) 1983-11-22
FR2536400B1 (fr) 1986-07-11
IT8323819A1 (it) 1985-05-22
GB2130586A (en) 1984-06-06

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