ES8401975A1 - Procedimiento para la obtencion de tiopiranos. - Google Patents
Procedimiento para la obtencion de tiopiranos.Info
- Publication number
- ES8401975A1 ES8401975A1 ES521233A ES521233A ES8401975A1 ES 8401975 A1 ES8401975 A1 ES 8401975A1 ES 521233 A ES521233 A ES 521233A ES 521233 A ES521233 A ES 521233A ES 8401975 A1 ES8401975 A1 ES 8401975A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- phenyl
- thiopyrans
- alkyl radical
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004884 4H-thiopyrans Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000686 lactone group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 150000004882 thiopyrans Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Glass Compositions (AREA)
- Dental Preparations (AREA)
- Materials For Medical Uses (AREA)
- Luminescent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Paper (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE TIOPIRANOS.-CONSISTE EN QUE POR LA REACCION DE LAS TIONAS DE FORMULA (II), EN LA QUE R, PUEDE SER ARILO, FURILO O PIRILO, EN LA QUE R Y R PUEDEN SER HIDROGENOS O RESTOS ALQUILOS ALQUIRALES DE CADENA RECTA SEGUN R, EN LA QUE X PUEDE SER OXIGENO O AZUFRE, CON ACETILCARBONATOS DE FORMULA (III), EN LA QUE R PUEDE SER HIDROGENO O UN RESTO ALQUILO ALQUIRAL DE CADENA RECTA Y R HIDROGENO, ALQUILO, ARILO, SE OBTIENEN LOS COMPUESTOS DE FORMULA (I). DICHA REACCION SE REALIZA A TEMPERATURAS ENTRE 50 Y 150JC Y EN PRESENCIA DE DISOLVENTESORGANICOS COMO TOLUENO Y ETANOL.TIENEN APLICACIONES FARMACOLOGICAS, COMO VASODILATADORES Y TERAPEUTICAS CORONARIAS, DEBIDO A SU EFECTO INFLUENCIADOR DE LA CIRCULACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823212737 DE3212737A1 (de) | 1982-04-06 | 1982-04-06 | 4h-thiopyrane, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES521233A0 ES521233A0 (es) | 1984-01-01 |
| ES8401975A1 true ES8401975A1 (es) | 1984-01-01 |
Family
ID=6160333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES521233A Expired ES8401975A1 (es) | 1982-04-06 | 1983-04-05 | Procedimiento para la obtencion de tiopiranos. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0091051B1 (es) |
| JP (1) | JPS58183685A (es) |
| KR (1) | KR840004423A (es) |
| AT (1) | ATE24003T1 (es) |
| CA (1) | CA1198107A (es) |
| DE (2) | DE3212737A1 (es) |
| DK (1) | DK151883A (es) |
| ES (1) | ES8401975A1 (es) |
| IL (1) | IL68283A0 (es) |
| ZA (1) | ZA832389B (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2310128A2 (fr) * | 1975-05-06 | 1976-12-03 | Little Inc A | Nouveaux thiopyranobenzopyranes, produits intermediaires et procede pour leur obtention |
| US4198426A (en) * | 1977-11-28 | 1980-04-15 | Ayerst Mckenna & Harrison Ltd. | 2-Substituted-3-methyl-γ-pyrone tricyclic derivatives |
-
1982
- 1982-04-06 DE DE19823212737 patent/DE3212737A1/de not_active Withdrawn
-
1983
- 1983-03-28 AT AT83103043T patent/ATE24003T1/de not_active IP Right Cessation
- 1983-03-28 DE DE8383103043T patent/DE3368058D1/de not_active Expired
- 1983-03-28 EP EP83103043A patent/EP0091051B1/de not_active Expired
- 1983-03-31 JP JP58054076A patent/JPS58183685A/ja active Pending
- 1983-03-31 CA CA000425122A patent/CA1198107A/en not_active Expired
- 1983-04-01 IL IL68283A patent/IL68283A0/xx unknown
- 1983-04-04 KR KR1019830001396A patent/KR840004423A/ko not_active Withdrawn
- 1983-04-05 ES ES521233A patent/ES8401975A1/es not_active Expired
- 1983-04-05 DK DK151883A patent/DK151883A/da not_active IP Right Cessation
- 1983-04-05 ZA ZA832389A patent/ZA832389B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0091051A2 (de) | 1983-10-12 |
| EP0091051A3 (en) | 1984-07-25 |
| DE3368058D1 (en) | 1987-01-15 |
| EP0091051B1 (de) | 1986-12-03 |
| ES521233A0 (es) | 1984-01-01 |
| ATE24003T1 (de) | 1986-12-15 |
| KR840004423A (ko) | 1984-10-15 |
| JPS58183685A (ja) | 1983-10-26 |
| DK151883A (da) | 1983-10-07 |
| IL68283A0 (en) | 1983-07-31 |
| DK151883D0 (da) | 1983-04-05 |
| DE3212737A1 (de) | 1983-10-06 |
| CA1198107A (en) | 1985-12-17 |
| ZA832389B (en) | 1983-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20010402 |