ES8402829A1 - Procedimiento para la preparacion de derivados de tiazolina. - Google Patents
Procedimiento para la preparacion de derivados de tiazolina.Info
- Publication number
- ES8402829A1 ES8402829A1 ES518271A ES518271A ES8402829A1 ES 8402829 A1 ES8402829 A1 ES 8402829A1 ES 518271 A ES518271 A ES 518271A ES 518271 A ES518271 A ES 518271A ES 8402829 A1 ES8402829 A1 ES 8402829A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- derivatives
- tiazoline
- procedure
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE TIAZOLINA.CONSISTE EN SOMETER A UNA REACCION DE DESHIDRATACION, MEDIANTE CATALISIS PROTONICA COMPUESTOS DE FORMULA (II), EN PRESENCIA DE DISOLVENTE ORGANICO POLAR O EN PRESENCIA DE UNA MEZCLA DE AGUA Y DISOLVENTE ORGANICO POLAR PARA DAR COMPUESTOS DE FORMULA (I), Y POSTERIORMENTE TRANSFORMAR EL COMPUESTOS DE FORMULA (I) EN SUS SALES POR ADICION DE ACIDOS ORGANICOS O INORGANICOS DE FORMULA GENERAL H-A. EL CATALIZADOR EMPLEADO PUEDE SER UN ACIDO CARBOXILICO ALIFATICO, LOS DISOLVENTES UTILIZADOS SON METANOL, ETANOL, PROPANOLY OTROS, Y LAS TEMPERATURAS DE REACCION ESTAN COMPRENDIDAS ENTRE 0 Y 200JC.TIENE APLICACIONES FARMACOLOGICAS POR SU EFECTO FAVORABLE SOBRE LAS LIPOPROTEINAS DEL SUERO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803049460 DE3049460A1 (de) | 1980-12-30 | 1980-12-30 | "thiazolinderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8402829A1 true ES8402829A1 (es) | 1984-02-16 |
| ES518271A0 ES518271A0 (es) | 1984-02-16 |
Family
ID=6120529
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508293A Granted ES508293A0 (es) | 1980-12-30 | 1981-12-23 | "procedimiento para la preparacion de derivados de tiazolina". |
| ES518274A Expired ES8308551A1 (es) | 1980-12-30 | 1982-12-16 | Procedimiento para la preparacion de derivados de tiazolina. |
| ES518271A Granted ES518271A0 (es) | 1980-12-30 | 1982-12-16 | Procedimiento para la preparacion de derivados de tiazolina. |
| ES518272A Granted ES518272A0 (es) | 1980-12-30 | 1982-12-16 | Procedimiento para la preparacion de derivados de tiazolina. |
| ES518273A Granted ES518273A0 (es) | 1980-12-30 | 1982-12-16 | Procedimiento para la preparacion de derivados de tiazolina. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508293A Granted ES508293A0 (es) | 1980-12-30 | 1981-12-23 | "procedimiento para la preparacion de derivados de tiazolina". |
| ES518274A Expired ES8308551A1 (es) | 1980-12-30 | 1982-12-16 | Procedimiento para la preparacion de derivados de tiazolina. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES518272A Granted ES518272A0 (es) | 1980-12-30 | 1982-12-16 | Procedimiento para la preparacion de derivados de tiazolina. |
| ES518273A Granted ES518273A0 (es) | 1980-12-30 | 1982-12-16 | Procedimiento para la preparacion de derivados de tiazolina. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4421757A (es) |
| EP (1) | EP0055458B1 (es) |
| JP (1) | JPS57134472A (es) |
| KR (1) | KR830007601A (es) |
| AR (2) | AR231134A1 (es) |
| AT (1) | ATE11778T1 (es) |
| AU (1) | AU542670B2 (es) |
| CA (1) | CA1173836A (es) |
| DE (2) | DE3049460A1 (es) |
| DK (1) | DK581181A (es) |
| ES (5) | ES508293A0 (es) |
| FI (1) | FI814175L (es) |
| HU (1) | HU184976B (es) |
| IE (1) | IE52259B1 (es) |
| IL (1) | IL64653A (es) |
| NO (1) | NO154551B (es) |
| ZA (1) | ZA818968B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4761422A (en) * | 1986-11-20 | 1988-08-02 | Lusofarmaco Istituto Lusofarmaco D'italia Spa | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same |
| AU2708700A (en) * | 1999-01-14 | 2000-08-01 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| US6353006B1 (en) | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| FR2796643B1 (fr) * | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
| FR2819508B1 (fr) * | 2001-01-12 | 2005-01-21 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydorthiazoles, leurs procedes de preparation et leur utilisation therapeutiques |
| EP1219612B1 (en) | 1999-09-14 | 2008-04-23 | Shionogi & Co., Ltd. | 2-imino-1,3-thiazine derivatives |
| EP1635800A2 (en) * | 2003-06-10 | 2006-03-22 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
| US7271195B2 (en) | 2003-06-10 | 2007-09-18 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2436263C2 (de) * | 1974-07-27 | 1983-02-17 | Hoechst Ag, 6000 Frankfurt | Thiazolidinderivate und Verfahren zu ihrer Herstellung |
| DE2533821A1 (de) * | 1975-07-29 | 1977-02-17 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| DE2546165A1 (de) * | 1975-10-15 | 1977-04-28 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| SE7700436L (sv) * | 1976-01-17 | 1977-07-18 | Hoechst Ag | Tiazolidinderivat och forfarande for deras framstellning |
| DE2926771A1 (de) * | 1979-07-03 | 1981-01-15 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
-
1980
- 1980-12-30 DE DE19803049460 patent/DE3049460A1/de not_active Withdrawn
-
1981
- 1981-12-22 EP EP81110677A patent/EP0055458B1/de not_active Expired
- 1981-12-22 AT AT81110677T patent/ATE11778T1/de not_active IP Right Cessation
- 1981-12-22 DE DE8181110677T patent/DE3168978D1/de not_active Expired
- 1981-12-23 IE IE3057/81A patent/IE52259B1/en unknown
- 1981-12-23 ES ES508293A patent/ES508293A0/es active Granted
- 1981-12-28 IL IL64653A patent/IL64653A/xx unknown
- 1981-12-28 US US06/335,149 patent/US4421757A/en not_active Expired - Fee Related
- 1981-12-28 AR AR287966A patent/AR231134A1/es active
- 1981-12-28 FI FI814175A patent/FI814175L/fi not_active Application Discontinuation
- 1981-12-28 JP JP56210093A patent/JPS57134472A/ja active Pending
- 1981-12-29 NO NO814468A patent/NO154551B/no unknown
- 1981-12-29 ZA ZA818968A patent/ZA818968B/xx unknown
- 1981-12-29 HU HU813984A patent/HU184976B/hu unknown
- 1981-12-29 DK DK581181A patent/DK581181A/da not_active Application Discontinuation
- 1981-12-29 CA CA000393285A patent/CA1173836A/en not_active Expired
- 1981-12-30 AU AU79068/81A patent/AU542670B2/en not_active Ceased
- 1981-12-30 KR KR1019810005232A patent/KR830007601A/ko not_active Withdrawn
-
1982
- 1982-11-30 AR AR291445A patent/AR231978A1/es active
- 1982-12-16 ES ES518274A patent/ES8308551A1/es not_active Expired
- 1982-12-16 ES ES518271A patent/ES518271A0/es active Granted
- 1982-12-16 ES ES518272A patent/ES518272A0/es active Granted
- 1982-12-16 ES ES518273A patent/ES518273A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ATE11778T1 (de) | 1985-02-15 |
| ES8308550A1 (es) | 1983-09-01 |
| AU7906881A (en) | 1982-07-08 |
| JPS57134472A (en) | 1982-08-19 |
| DE3168978D1 (en) | 1985-03-28 |
| IL64653A (en) | 1985-09-29 |
| KR830007601A (ko) | 1983-11-04 |
| FI814175A7 (fi) | 1982-07-01 |
| ES518274A0 (es) | 1983-09-01 |
| CA1173836A (en) | 1984-09-04 |
| US4421757A (en) | 1983-12-20 |
| ES8308549A1 (es) | 1983-09-01 |
| NO154551B (no) | 1986-07-07 |
| AR231978A1 (es) | 1985-04-30 |
| EP0055458B1 (de) | 1985-02-13 |
| ZA818968B (en) | 1982-11-24 |
| IL64653A0 (en) | 1982-03-31 |
| AU542670B2 (en) | 1985-02-28 |
| DE3049460A1 (de) | 1982-07-29 |
| NO814468L (no) | 1982-07-01 |
| IE52259B1 (en) | 1987-08-19 |
| EP0055458A2 (de) | 1982-07-07 |
| ES8308551A1 (es) | 1983-09-01 |
| IE813057L (en) | 1982-06-30 |
| FI814175L (fi) | 1982-07-01 |
| HU184976B (en) | 1984-11-28 |
| ES518273A0 (es) | 1983-09-01 |
| ES8305342A1 (es) | 1983-04-01 |
| DK581181A (da) | 1982-07-01 |
| ES508293A0 (es) | 1983-04-01 |
| ES518272A0 (es) | 1983-09-01 |
| EP0055458A3 (en) | 1982-10-20 |
| ES518271A0 (es) | 1984-02-16 |
| AR231134A1 (es) | 1984-09-28 |
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