KR830007601A - 티아졸린 유도체의 제조방법 - Google Patents

티아졸린 유도체의 제조방법 Download PDF

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Publication number
KR830007601A
KR830007601A KR1019810005232A KR810005232A KR830007601A KR 830007601 A KR830007601 A KR 830007601A KR 1019810005232 A KR1019810005232 A KR 1019810005232A KR 810005232 A KR810005232 A KR 810005232A KR 830007601 A KR830007601 A KR 830007601A
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South Korea
Prior art keywords
formula
compound
hydrogen
carbon atoms
general formula
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KR1019810005232A
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English (en)
Inventor
랑 한스-죠켄
하르드 세우링 베른
그란저 에르놀드
Original Assignee
하인리히 벡커, 베른하르드트 벡크
훽스트 아크티엔 게젤샤프트
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Application filed by 하인리히 벡커, 베른하르드트 벡크, 훽스트 아크티엔 게젤샤프트 filed Critical 하인리히 벡커, 베른하르드트 벡크
Publication of KR830007601A publication Critical patent/KR830007601A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

티아졸린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 일반식(Ⅱ)의 화합물을 축합 조건하에 하기 일반식(Ⅲ)의 티오우레아와 반응시키거나, 하기 일반식(Ⅳ) 화합물로부터 물을 제거하거나, 하기 일반식(Ⅴ) 화합물을 하기 일반식(Ⅵ) 화합물과 반응시키거나, 하기 일반식(Ⅶ) 화합물을 가수분해 또는 용매분해시켜 R6가 수소인 일반식(Ⅰ) 화합물로 전환시키거나, R1내지 R5및 Y가 후술하는 바와 같고 R6가 수소인 일반식(Ⅰ) 화합물을 아실화제로 R6가 탄소원자 1-4개의 아실기인 하기 일반식(Ⅰ) 화합물로 전환시키고, 필요에 따라, 상기 공정중 어느 하나에 의해 제조된 일반식(Ⅰ) 화합물 중의 하나를 일반 구조식 H-A의 유기 또는 무기산으로 그의 산부가염으로 전환시키거나, 이때 생성된 일반식(I) 화합물의 염을 염기로 일반식(Ⅰ)의 유리 기본화합물로 전환시키거나, R6가 수소인 일반식(Ⅰ)의 생성된 화합물로 유기 또는 무기 염기로 그의 페놀레이트 염으로 전환시키거나 상응적으로 수득된 염을 산으로 일반식(Ⅰ)의 유리 기본 화합물로 전환시켜하기 일반식(Ⅰ)의 티아졸린 유도체 및 그의 생리학적으로 허용되는 염을 제조하는 방법.
    상기식에서,
    R1은 탄소원자 1-3개의 알킬이고,
    R2및 R3는 수소, 할로겐, 탄소원자 1-4개의 알킬 또는 알콕시이며 같거나 다르고,
    R4및 R5는 수소 또는 탄소원자 1-4개의 알킬이며 같거나 다르고 또는 N원자와 함께 최고 6각형의 표화 고리를 이루고,
    R6는 수소 또는 탄소원자 1-4개의 아실이고,
    Y는 수소, 할로겐 또는 메틸이고,
    X는 유리기이고,
    Z는 페놀성 하이드록실기의 보호기이고,
    X'는 유리기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810005232A 1980-12-30 1981-12-30 티아졸린 유도체의 제조방법 Withdrawn KR830007601A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE30.49.460.1 1980-12-30
DE19803049460 DE3049460A1 (de) 1980-12-30 1980-12-30 "thiazolinderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen

Publications (1)

Publication Number Publication Date
KR830007601A true KR830007601A (ko) 1983-11-04

Family

ID=6120529

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810005232A Withdrawn KR830007601A (ko) 1980-12-30 1981-12-30 티아졸린 유도체의 제조방법

Country Status (17)

Country Link
US (1) US4421757A (ko)
EP (1) EP0055458B1 (ko)
JP (1) JPS57134472A (ko)
KR (1) KR830007601A (ko)
AR (2) AR231134A1 (ko)
AT (1) ATE11778T1 (ko)
AU (1) AU542670B2 (ko)
CA (1) CA1173836A (ko)
DE (2) DE3049460A1 (ko)
DK (1) DK581181A (ko)
ES (5) ES508293A0 (ko)
FI (1) FI814175L (ko)
HU (1) HU184976B (ko)
IE (1) IE52259B1 (ko)
IL (1) IL64653A (ko)
NO (1) NO154551B (ko)
ZA (1) ZA818968B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761422A (en) * 1986-11-20 1988-08-02 Lusofarmaco Istituto Lusofarmaco D'italia Spa (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same
AU2708700A (en) * 1999-01-14 2000-08-01 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
US6353006B1 (en) 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
FR2796643B1 (fr) * 1999-07-22 2005-04-29 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique
FR2819508B1 (fr) * 2001-01-12 2005-01-21 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydorthiazoles, leurs procedes de preparation et leur utilisation therapeutiques
EP1219612B1 (en) 1999-09-14 2008-04-23 Shionogi & Co., Ltd. 2-imino-1,3-thiazine derivatives
EP1635800A2 (en) * 2003-06-10 2006-03-22 Kalypsys, Inc. Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
US7271195B2 (en) 2003-06-10 2007-09-18 Kalypsys, Inc. Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2436263C2 (de) * 1974-07-27 1983-02-17 Hoechst Ag, 6000 Frankfurt Thiazolidinderivate und Verfahren zu ihrer Herstellung
DE2533821A1 (de) * 1975-07-29 1977-02-17 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE2546165A1 (de) * 1975-10-15 1977-04-28 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
SE7700436L (sv) * 1976-01-17 1977-07-18 Hoechst Ag Tiazolidinderivat och forfarande for deras framstellning
DE2926771A1 (de) * 1979-07-03 1981-01-15 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ATE11778T1 (de) 1985-02-15
ES8402829A1 (es) 1984-02-16
ES8308550A1 (es) 1983-09-01
AU7906881A (en) 1982-07-08
JPS57134472A (en) 1982-08-19
DE3168978D1 (en) 1985-03-28
IL64653A (en) 1985-09-29
FI814175A7 (fi) 1982-07-01
ES518274A0 (es) 1983-09-01
CA1173836A (en) 1984-09-04
US4421757A (en) 1983-12-20
ES8308549A1 (es) 1983-09-01
NO154551B (no) 1986-07-07
AR231978A1 (es) 1985-04-30
EP0055458B1 (de) 1985-02-13
ZA818968B (en) 1982-11-24
IL64653A0 (en) 1982-03-31
AU542670B2 (en) 1985-02-28
DE3049460A1 (de) 1982-07-29
NO814468L (no) 1982-07-01
IE52259B1 (en) 1987-08-19
EP0055458A2 (de) 1982-07-07
ES8308551A1 (es) 1983-09-01
IE813057L (en) 1982-06-30
FI814175L (fi) 1982-07-01
HU184976B (en) 1984-11-28
ES518273A0 (es) 1983-09-01
ES8305342A1 (es) 1983-04-01
DK581181A (da) 1982-07-01
ES508293A0 (es) 1983-04-01
ES518272A0 (es) 1983-09-01
EP0055458A3 (en) 1982-10-20
ES518271A0 (es) 1984-02-16
AR231134A1 (es) 1984-09-28

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PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19811230

PG1501 Laying open of application
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