ES8403105A1 - Un procedimiento para la preparacion de derivados de guanidina. - Google Patents

Un procedimiento para la preparacion de derivados de guanidina.

Info

Publication number
ES8403105A1
ES8403105A1 ES519666A ES519666A ES8403105A1 ES 8403105 A1 ES8403105 A1 ES 8403105A1 ES 519666 A ES519666 A ES 519666A ES 519666 A ES519666 A ES 519666A ES 8403105 A1 ES8403105 A1 ES 8403105A1
Authority
ES
Spain
Prior art keywords
hydroxy
guanidine derivatives
alkoxy
halogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519666A
Other languages
English (en)
Other versions
ES519666A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES519666A0 publication Critical patent/ES519666A0/es
Publication of ES8403105A1 publication Critical patent/ES8403105A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE GUANIDINA, DE FORMULA (I), EN LA QUE Y ES -CHFN; R1 ES HIDROXI, HALOGENO O ALQUILO; R2 ES UN SUSTITUYENTE BASICO QUE CONTIENE NITROGENO; R3 ES HIDROGENO, HIDROXI, HALOGENO O ALQUILO; Y R4 ES HIDROGENO O HIDROXI, Y SUS SALES Y DERIVADOS ACILADOS.CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA (II), EN LA QUE X1 ES UN GRUPO NITRO O R2; X2 ES UN GRUPO NITRO O R3; Y R1, R2, R3 E Y SE DEFINEN COMO YA SE HA INDICADO, PARA PRODUCIR UN COMPUESTO DE FORMULA (I).DE APLICACION EN EL TRATAMIENTO DE LA DIARREA Y DELA DIARREA BLANCA.
ES519666A 1982-02-10 1983-02-09 Un procedimiento para la preparacion de derivados de guanidina. Expired ES8403105A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8203916 1982-02-10

Publications (2)

Publication Number Publication Date
ES519666A0 ES519666A0 (es) 1984-03-01
ES8403105A1 true ES8403105A1 (es) 1984-03-01

Family

ID=10528238

Family Applications (2)

Application Number Title Priority Date Filing Date
ES519666A Expired ES8403105A1 (es) 1982-02-10 1983-02-09 Un procedimiento para la preparacion de derivados de guanidina.
ES525586A Granted ES525586A0 (es) 1982-02-10 1983-09-13 Un procedimiento para la preparacion de nuevos derivados de guanidina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES525586A Granted ES525586A0 (es) 1982-02-10 1983-09-13 Un procedimiento para la preparacion de nuevos derivados de guanidina

Country Status (10)

Country Link
US (1) US4602041A (es)
EP (1) EP0087218B1 (es)
JP (1) JPS58185544A (es)
AU (1) AU1122983A (es)
CA (1) CA1187900A (es)
DE (1) DE3360148D1 (es)
DK (1) DK53483A (es)
ES (2) ES8403105A1 (es)
NZ (1) NZ203221A (es)
ZA (1) ZA83817B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8313588D0 (en) * 1983-05-17 1983-06-22 Beecham Group Plc Compounds
GB8327561D0 (en) * 1983-10-14 1983-11-16 Ici Plc Contraceptive methods
GB8508588D0 (en) * 1985-04-02 1985-05-09 Akzo Nv Indene & napthalene derivatives
US4851441A (en) * 1986-06-26 1989-07-25 Harbor Branch Oceanographic Institution, Inc. Antiviral guanidine derivatives compositions and their methods of use
US4870210A (en) * 1987-12-18 1989-09-26 American Home Products Corporation Aminoguanidine derivative as anti-inflammatory agents
US4971986A (en) * 1988-03-25 1990-11-20 Ciba-Geigy Corporation Arylhydrazones useful as SAMDC inhibitors
US5238941A (en) * 1988-03-25 1993-08-24 Ciba-Geigy Corporation Arylhydrazones and pharmaceutical compositions thereof
HUT64023A (en) * 1991-03-22 1993-11-29 Sandoz Ag Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
US5510380A (en) * 1993-02-19 1996-04-23 Sterling Winthrop, Inc. Nonpeptide bradykinin antagonists
TW415937B (en) * 1994-01-25 2000-12-21 Hoechst Ag Phenyl-substituted alkylcarboxylic acid guanidides bearing perfluoroalkyl groups, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
AU5115396A (en) * 1995-03-17 1996-10-08 Radopath Limited Anti-viral and anti-cancer agents
WO2025068452A1 (en) * 2023-09-29 2025-04-03 Negio Therapeutics Guanfacine derivatives and their use in treating cancer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734904A (en) * 1956-02-14 Xcxnhxc-nh
CH383948A (de) * 1959-07-22 1964-11-15 Ciba Geigy Verfahren zur Herstellung neuer Hydrazone
CH396881A (de) * 1961-01-16 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Hydrazone
CH430694A (de) * 1962-04-03 1967-02-28 Ciba Geigy Verfahren zur Herstellung neuer Guanylhydrazone
US3320229A (en) * 1963-08-26 1967-05-16 Stauffer Chemical Co Complexes of guanidines with completely halogenated acetones
CH474486A (de) * 1965-11-19 1969-06-30 Ciba Geigy Verfahren zur Herstellung neuer Diphenylharnstoffe
GB1223492A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
GB1298112A (en) * 1969-02-20 1972-11-29 Wander Ag Dr A Phenyl acetyl guanidine derivatives
US4018814A (en) * 1970-06-13 1977-04-19 Bayer Aktiengesellschaft Aromatic amides and carbomates of phenylamidines
DE2931735A1 (de) * 1979-08-04 1981-02-19 Beiersdorf Ag Neue substituierte phenylacetylguanidine und verfahren zu ihrer herstellung
EP0025269B1 (en) * 1979-08-23 1985-11-13 Beecham Group Plc Anti-diarrhoea veterinary composition
DE3168754D1 (en) * 1980-07-09 1985-03-21 Beecham Group Plc Clonidine derivatives useful in the treatment of diarrhoea

Also Published As

Publication number Publication date
ES8503326A1 (es) 1985-02-16
DK53483A (da) 1983-08-11
ZA83817B (en) 1983-12-28
CA1187900A (en) 1985-05-28
DE3360148D1 (en) 1985-06-05
AU1122983A (en) 1983-08-18
ES525586A0 (es) 1985-02-16
ES519666A0 (es) 1984-03-01
DK53483D0 (da) 1983-02-08
US4602041A (en) 1986-07-22
NZ203221A (en) 1986-01-24
JPS58185544A (ja) 1983-10-29
EP0087218A1 (en) 1983-08-31
EP0087218B1 (en) 1985-05-02

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