ES8403120A1 - Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas - Google Patents
Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidasInfo
- Publication number
- ES8403120A1 ES8403120A1 ES519531A ES519531A ES8403120A1 ES 8403120 A1 ES8403120 A1 ES 8403120A1 ES 519531 A ES519531 A ES 519531A ES 519531 A ES519531 A ES 519531A ES 8403120 A1 ES8403120 A1 ES 8403120A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- procedure
- preparation
- dibenzodiazepinones
- new substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DIBENZODIAZEPINONAS SUSTITUIDAS, DE FORMULA GENERAL (I).CONSISTE EN ACILAR DIBENZODIAZEPINONAS, DE FORMULA GENERAL (II), EN LA ACILAR DIBENZODIAZEPINONAS, DE FORMULA GENERAL (II), EN LA QUE R1 TIENEN EL SIGNIFICADO YA MENCIONADO, CON DERIVADOS DE ACIDOS DE FORMULA GENERAL (III), EN LA QUE R TIENE EL SIGNIFICADO YA MENCIONADO; Y Z SIGNIFICA UN GRUPO NUCLEOFUGO, EN UN DISOLVENTE INERTE A TEMPERATURAS COMPRENDIDAS ENTRE C25 Y B130 GRADOS.DE APLICACION EN MEDICINA POR SU EFECTO INHIBIDOR DE ULCERAS Y SECRECIONES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823204157 DE3204157A1 (de) | 1982-02-06 | 1982-02-06 | Substituierte dibenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES519531A0 ES519531A0 (es) | 1984-03-01 |
| ES8403120A1 true ES8403120A1 (es) | 1984-03-01 |
Family
ID=6155013
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519531A Expired ES8403120A1 (es) | 1982-02-06 | 1983-02-04 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
| ES526729A Granted ES526729A0 (es) | 1982-02-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
| ES526728A Expired ES8501389A1 (es) | 1982-02-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
| ES526727A Expired ES8501388A1 (es) | 1982-02-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
| ES526726A Expired ES8501387A1 (es) | 1982-02-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526729A Granted ES526729A0 (es) | 1982-02-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
| ES526728A Expired ES8501389A1 (es) | 1982-02-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
| ES526727A Expired ES8501388A1 (es) | 1982-02-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
| ES526726A Expired ES8501387A1 (es) | 1982-02-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4447434A (es) |
| EP (1) | EP0085892B1 (es) |
| JP (1) | JPS58146581A (es) |
| KR (1) | KR900005278B1 (es) |
| AT (1) | ATE17002T1 (es) |
| AU (1) | AU557463B2 (es) |
| CA (1) | CA1189507A (es) |
| CS (1) | CS241138B2 (es) |
| DD (1) | DD207200A1 (es) |
| DE (2) | DE3204157A1 (es) |
| DK (1) | DK48983A (es) |
| ES (5) | ES8403120A1 (es) |
| FI (1) | FI75818C (es) |
| GB (1) | GB2115411B (es) |
| GR (1) | GR78060B (es) |
| HK (1) | HK90189A (es) |
| HU (1) | HU190708B (es) |
| IE (1) | IE54552B1 (es) |
| IL (1) | IL67836A (es) |
| NO (1) | NO158623C (es) |
| NZ (1) | NZ203192A (es) |
| PL (1) | PL138523B1 (es) |
| PT (1) | PT76198B (es) |
| SU (1) | SU1301314A3 (es) |
| ZA (1) | ZA83774B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3402060A1 (de) * | 1984-01-21 | 1985-08-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3531682A1 (de) * | 1985-09-05 | 1987-03-12 | Thomae Gmbh Dr K | (+)-6-chlor-5,10-dihydro-5-((1-methyl-4- piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4) diazepin-11-on, seine isolierung und verwendung als arzneimittel |
| US4719149A (en) | 1986-02-28 | 1988-01-12 | Minnesota Mining And Manufacturing Company | Method for priming hard tissue |
| DE3726908A1 (de) * | 1987-08-13 | 1989-02-23 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3738980A1 (de) * | 1987-11-17 | 1989-05-24 | Thomae Gmbh Dr K | Mittel zur behandlung von ischaemischen herzerkrankungen |
| DE3838912A1 (de) * | 1988-11-17 | 1990-05-23 | Thomae Gmbh Dr K | Mittel zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen |
| BRPI0006503B1 (pt) * | 2000-02-04 | 2017-05-09 | Biolab Sanus Farmacêutica Ltda | composição em forma de gel, creme, aerosol, spray, líquida e liofilizada de substância carreadora de produtos à base de papaína |
| WO2004058700A2 (en) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| US20070105835A1 (en) * | 2005-11-07 | 2007-05-10 | Kazantsev Aleksey G | Compositions and methods for modulating poly(ADP-ribose) polymerase activity |
| CN103980212A (zh) * | 2014-05-15 | 2014-08-13 | 南京工业大学 | 一锅法合成二苯二氮卓杂环衍生物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1795176C3 (de) * | 1968-08-20 | 1974-10-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | hT-substituierte 5-Aminoacetyl-5,10-dihydro-l lH-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11one und Verfahren zu ihrer Herstellung |
| IL61642A0 (en) * | 1979-12-20 | 1981-01-30 | Beecham Group Ltd | Aniline derivatives,their preparation and pharmalceutical compositions containing them |
| DE3028001A1 (de) * | 1980-07-24 | 1982-02-18 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue, in 5-stellung substituierte 5,10-dihydro-11h-dibenzo (b,e)(1,4) diazepin-11-one, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel |
-
1982
- 1982-02-06 DE DE19823204157 patent/DE3204157A1/de not_active Withdrawn
-
1983
- 1983-01-26 EP EP83100677A patent/EP0085892B1/de not_active Expired
- 1983-01-26 DE DE8383100677T patent/DE3361504D1/de not_active Expired
- 1983-01-26 AT AT83100677T patent/ATE17002T1/de not_active IP Right Cessation
- 1983-01-31 US US06/462,149 patent/US4447434A/en not_active Expired - Fee Related
- 1983-02-01 FI FI830337A patent/FI75818C/fi not_active IP Right Cessation
- 1983-02-04 AU AU11123/83A patent/AU557463B2/en not_active Ceased
- 1983-02-04 PT PT76198A patent/PT76198B/pt unknown
- 1983-02-04 HU HU83396A patent/HU190708B/hu not_active IP Right Cessation
- 1983-02-04 NO NO830386A patent/NO158623C/no unknown
- 1983-02-04 JP JP58017291A patent/JPS58146581A/ja active Granted
- 1983-02-04 ES ES519531A patent/ES8403120A1/es not_active Expired
- 1983-02-04 ZA ZA83774A patent/ZA83774B/xx unknown
- 1983-02-04 IE IE219/83A patent/IE54552B1/en not_active IP Right Cessation
- 1983-02-04 CS CS83784A patent/CS241138B2/cs unknown
- 1983-02-04 NZ NZ203192A patent/NZ203192A/en unknown
- 1983-02-04 IL IL67836A patent/IL67836A/xx unknown
- 1983-02-04 CA CA000420920A patent/CA1189507A/en not_active Expired
- 1983-02-04 DK DK48983A patent/DK48983A/da not_active Application Discontinuation
- 1983-02-04 GR GR70419A patent/GR78060B/el unknown
- 1983-02-04 KR KR1019830000430A patent/KR900005278B1/ko not_active Expired
- 1983-02-04 GB GB08303102A patent/GB2115411B/en not_active Expired
- 1983-02-04 PL PL1983240437A patent/PL138523B1/pl unknown
- 1983-02-04 SU SU833550248A patent/SU1301314A3/ru active
- 1983-02-04 DD DD83247724A patent/DD207200A1/xx not_active IP Right Cessation
- 1983-10-25 ES ES526729A patent/ES526729A0/es active Granted
- 1983-10-25 ES ES526728A patent/ES8501389A1/es not_active Expired
- 1983-10-25 ES ES526727A patent/ES8501388A1/es not_active Expired
- 1983-10-25 ES ES526726A patent/ES8501387A1/es not_active Expired
-
1989
- 1989-11-16 HK HK901/89A patent/HK90189A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |