ES8403126A1 - Procedimiento de separacion de los enantiomeros del hexahidro-2,3,3a,4,5,6-1h-indol(3,2,1-de) (naftiridina-1,5) - Google Patents

Procedimiento de separacion de los enantiomeros del hexahidro-2,3,3a,4,5,6-1h-indol(3,2,1-de) (naftiridina-1,5)

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Publication number
ES8403126A1
ES8403126A1 ES522478A ES522478A ES8403126A1 ES 8403126 A1 ES8403126 A1 ES 8403126A1 ES 522478 A ES522478 A ES 522478A ES 522478 A ES522478 A ES 522478A ES 8403126 A1 ES8403126 A1 ES 8403126A1
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Prior art keywords
enantiomers
indolo
naphthyridine
hexahydro
enantiomer
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Expired
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ES522478A
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ES522478A0 (es
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Synthelabo SA
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Synthelabo SA
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Publication of ES522478A0 publication Critical patent/ES522478A0/es
Publication of ES8403126A1 publication Critical patent/ES8403126A1/es
Expired legal-status Critical Current

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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
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    • C10M2227/00—Organic non-macromolecular compounds containing atoms of elements not provided for in groups C10M2203/00, C10M2207/00, C10M2211/00, C10M2215/00, C10M2219/00 or C10M2223/00 as ingredients in lubricant compositions
    • C10M2227/06—Organic compounds derived from inorganic acids or metal salts
    • C10M2227/063—Complexes of boron halides
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2227/00—Organic non-macromolecular compounds containing atoms of elements not provided for in groups C10M2203/00, C10M2207/00, C10M2211/00, C10M2215/00, C10M2219/00 or C10M2223/00 as ingredients in lubricant compositions
    • C10M2227/06—Organic compounds derived from inorganic acids or metal salts
    • C10M2227/065—Organic compounds derived from inorganic acids or metal salts derived from Ti or Zr
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2227/00—Organic non-macromolecular compounds containing atoms of elements not provided for in groups C10M2203/00, C10M2207/00, C10M2211/00, C10M2215/00, C10M2219/00 or C10M2223/00 as ingredients in lubricant compositions
    • C10M2227/06—Organic compounds derived from inorganic acids or metal salts
    • C10M2227/066—Organic compounds derived from inorganic acids or metal salts derived from Mo or W
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2010/00—Metal present as such or in compounds
    • C10N2010/04—Groups 2 or 12
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B1/00—Engines characterised by fuel-air mixture compression
    • F02B1/02—Engines characterised by fuel-air mixture compression with positive ignition
    • F02B1/04—Engines characterised by fuel-air mixture compression with positive ignition with fuel-air mixture admission into cylinder
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02F—CYLINDERS, PISTONS OR CASINGS, FOR COMBUSTION ENGINES; ARRANGEMENTS OF SEALINGS IN COMBUSTION ENGINES
    • F02F7/00—Casings, e.g. crankcases
    • F02F7/006—Camshaft or pushrod housings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA SEPARACION DE LOS ENANTIOMEROS DEL HEXAHIDRO-2,3,3A,4,5,6-AH-INDOL3,2,1-DE NAFTIRIDINA-1,5.CONSISTE EN HACER REACCIONAR UNA MEZCLA DE ENANTIOMEROS, DE FORMULA (I) EN FORMA DE UNA BASE, CON UNO DE LOS ENANTIOMEROS DE UN ACIDO QUIRAL. SE SEPARA UNA DE LAS DOS SALES DIASTEREOISOMERAS ASI OBTENIDAS, POR CRISTALIZACION FRACCIONADA Y SE VUELVE A PONER EN FORMA DE BASE Y, SI SE DESEA, SE TRANSFORMA ESTA ULTIMA EN UNA SAL DE ADICION CON UN ACIDO FARMACEUTICO ACEPTABLE.DE APLICACION EN TERAPEUTICA.
ES522478A 1982-05-18 1983-05-17 Procedimiento de separacion de los enantiomeros del hexahidro-2,3,3a,4,5,6-1h-indol(3,2,1-de) (naftiridina-1,5) Expired ES8403126A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8208632A FR2527210A1 (fr) 1982-05-18 1982-05-18 Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de) (naphtyridine-1,5), leur procede de separation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES522478A0 ES522478A0 (es) 1984-03-01
ES8403126A1 true ES8403126A1 (es) 1984-03-01

Family

ID=9274131

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522478A Expired ES8403126A1 (es) 1982-05-18 1983-05-17 Procedimiento de separacion de los enantiomeros del hexahidro-2,3,3a,4,5,6-1h-indol(3,2,1-de) (naftiridina-1,5)

Country Status (19)

Country Link
JP (1) JPS58210083A (es)
AU (1) AU1461683A (es)
BE (1) BE896764A (es)
CH (1) CH654579B (es)
DE (1) DE3317961A1 (es)
DK (1) DK219183A (es)
ES (1) ES8403126A1 (es)
FR (1) FR2527210A1 (es)
GB (1) GB2120250A (es)
GR (1) GR78568B (es)
HU (1) HU189660B (es)
IL (1) IL68721A0 (es)
IT (1) IT1194244B (es)
LU (1) LU84808A1 (es)
NL (1) NL8301739A (es)
NO (1) NO831737L (es)
PT (1) PT76716B (es)
SE (1) SE8302747L (es)
ZA (1) ZA833539B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU84664A1 (fr) * 1983-02-25 1984-11-08 Onmichem S A Alkyl-4-indolonaphtyridines et leur application therapeutique
US5231181A (en) * 1991-03-21 1993-07-27 Syntex (U.S.A.) Inc. Process for the preparation of (8as,12as,13as)-decahydroisoquino ((2,1-g) (1,6)-naphthyridin-8-one derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES503557A0 (es) * 1980-07-03 1982-04-01 Omnichem Sa Procedimiento de preparacion de alquil-3 tetrahidro-1,2,3, 3a-4h-indolo(3,2,1-de)-1,5-naftiridinas.
FR2494693A1 (fr) * 1980-11-21 1982-05-28 Synthelabo Derives de l'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de)(naphtyridine-1,5), leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
PT76716B (fr) 1986-03-27
NL8301739A (nl) 1983-12-16
BE896764A (fr) 1983-11-17
PT76716A (fr) 1983-06-01
LU84808A1 (fr) 1985-03-21
ES522478A0 (es) 1984-03-01
DK219183D0 (da) 1983-05-17
JPS58210083A (ja) 1983-12-07
CH654579B (es) 1986-02-28
GR78568B (es) 1984-09-27
ZA833539B (en) 1984-02-29
DE3317961A1 (de) 1983-11-24
SE8302747L (sv) 1983-11-19
GB2120250A (en) 1983-11-30
FR2527210B1 (es) 1985-04-12
AU1461683A (en) 1983-11-24
IL68721A0 (en) 1983-09-30
HU189660B (en) 1986-07-28
SE8302747D0 (sv) 1983-05-16
IT8321143A0 (it) 1983-05-17
IT1194244B (it) 1988-09-14
NO831737L (no) 1983-11-21
FR2527210A1 (fr) 1983-11-25
GB8313625D0 (en) 1983-06-22
DK219183A (da) 1983-11-19

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