ES8404363A1 - Procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas. - Google Patents

Procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas.

Info

Publication number
ES8404363A1
ES8404363A1 ES520642A ES520642A ES8404363A1 ES 8404363 A1 ES8404363 A1 ES 8404363A1 ES 520642 A ES520642 A ES 520642A ES 520642 A ES520642 A ES 520642A ES 8404363 A1 ES8404363 A1 ES 8404363A1
Authority
ES
Spain
Prior art keywords
preparation
formula
alcohyl
halogen
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520642A
Other languages
English (en)
Other versions
ES520642A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES520642A0 publication Critical patent/ES520642A0/es
Publication of ES8404363A1 publication Critical patent/ES8404363A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE TIAZOLO3,2-APIRIMIDINAS SUSTITUIDAS, DE FORMULA GENERAL (I), EN LA QUE A COMPLETA UN ENLACE; R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, HALOGENO, TIENILO, PIRIDILO, UN GRUPO FENILO O UN GRUPO FENILO SUSTITUIDO; R3 REPRESENTA UN ATOMO DE HIDROGENO, HALOGENO O ALCOHILO C1-C4; Y R4 REPRESENTA UN GRUPO PIRIDILO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE R1, R2 Y R3 TIENEN LOS SIGNIFICADOS YA MENCIONADOS; Q ES ARILO O ALCOHILO C1-C6; E Y(-) REPRESENTA UNANION ACIDO, CON UN ALDEHIDO DE FORMULA: R4-CHO, EN LA QUE R4 TIENE EL SIGNIFICADO YA MENCIONADO.DE APLICACION EN TERAPIA, POR EJEMPLO EN LA PREVENCION Y TRATAMIENTO DE ULCERAS PEPTICAS.
ES520642A 1981-07-15 1983-03-16 Procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas. Expired ES8404363A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8121979 1981-07-15
GB8201621 1982-01-20
GB8212430 1982-04-29

Publications (2)

Publication Number Publication Date
ES520642A0 ES520642A0 (es) 1984-05-01
ES8404363A1 true ES8404363A1 (es) 1984-05-01

Family

ID=27261230

Family Applications (2)

Application Number Title Priority Date Filing Date
ES513808A Expired ES8307827A1 (es) 1981-07-15 1982-07-08 "procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas".
ES520642A Expired ES8404363A1 (es) 1981-07-15 1983-03-16 Procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES513808A Expired ES8307827A1 (es) 1981-07-15 1982-07-08 "procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas".

Country Status (25)

Country Link
US (2) US4444773A (es)
KR (1) KR880002301B1 (es)
AT (1) AT384614B (es)
AU (1) AU551718B2 (es)
CA (1) CA1208635A (es)
CH (1) CH653036A5 (es)
DE (1) DE3226516A1 (es)
DK (1) DK156222C (es)
ES (2) ES8307827A1 (es)
FI (1) FI71940C (es)
FR (1) FR2509734B1 (es)
GB (1) GB2103608B (es)
GR (1) GR76208B (es)
HU (1) HU186951B (es)
IE (1) IE53426B1 (es)
IL (1) IL66316A (es)
IT (1) IT1190914B (es)
LU (1) LU84262A1 (es)
NL (1) NL8202706A (es)
NO (1) NO822441L (es)
NZ (1) NZ201194A (es)
PT (1) PT75240B (es)
SE (2) SE453295B (es)
SU (1) SU1358786A3 (es)
YU (1) YU151582A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202706A (nl) * 1981-07-15 1983-02-01 Erba Farmitalia Gesubstitueerde thiazolo3,2-apyrimidinen en werkwijzen ter bereiding ervan.
US4537962A (en) * 1982-02-04 1985-08-27 Farmitalia Carlo Erba, S.P.A. Substituted 1,3,4-thiadiazolo[3,2-A]pyrimidines and compositions containing them
US4546101A (en) * 1982-09-10 1985-10-08 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
DE10112197A1 (de) * 2001-03-14 2002-09-19 Gruenenthal Gmbh Substituierte Pyrazolo- und Thiazolopyrimidine
GEP20125574B (en) * 2008-01-11 2012-07-10 Glenmark Pharmaceuticals Sa Fused pyrimidine derivatives as trpv3 modulators
US8119647B2 (en) * 2008-04-23 2012-02-21 Glenmark Pharmaceuticals S.A. Fused pyrimidineone compounds as TRPV3 modulators
EP2247601B1 (en) * 2008-07-02 2013-04-10 Avexa Limited Thiazopyrimidinones and uses thereof
CN106916168B (zh) * 2017-03-13 2019-08-27 牡丹江医学院 一种治疗重症胰腺炎的化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594378A (en) * 1969-10-24 1971-07-20 Ayerst Mckenna & Harrison Thiazolopyrimidine derivatives and preparation thereof
US3888983A (en) * 1970-08-14 1975-06-10 Seperic Derivatives of thiazolino-pyrimidin-6-ones, in inducing analgesia
GB2084568A (en) * 1980-08-16 1982-04-15 Beecham Group Ltd Imidazothiazole derivatives
NL8202706A (nl) * 1981-07-15 1983-02-01 Erba Farmitalia Gesubstitueerde thiazolo3,2-apyrimidinen en werkwijzen ter bereiding ervan.

Also Published As

Publication number Publication date
ES520642A0 (es) 1984-05-01
SE8204292L (sv) 1983-03-14
DE3226516A1 (de) 1983-02-03
PT75240B (en) 1984-07-23
YU151582A (en) 1985-04-30
SE8204292D0 (sv) 1982-07-12
IT8222353A1 (it) 1984-01-12
DK314682A (da) 1983-01-16
ATA266182A (de) 1987-05-15
FI822468A0 (fi) 1982-07-12
IE53426B1 (en) 1988-11-09
AU551718B2 (en) 1986-05-08
ES513808A0 (es) 1983-08-01
US4444773A (en) 1984-04-24
FR2509734B1 (fr) 1985-07-19
US4551457A (en) 1985-11-05
FI822468L (fi) 1983-01-16
IT1190914B (it) 1988-02-24
IE821692L (en) 1983-01-15
AU8564882A (en) 1983-01-20
NL8202706A (nl) 1983-02-01
DK156222B (da) 1989-07-10
CH653036A5 (de) 1985-12-13
CA1208635A (en) 1986-07-29
NO822441L (no) 1983-01-17
KR880002301B1 (ko) 1988-10-22
ES8307827A1 (es) 1983-08-01
GR76208B (es) 1984-08-03
GB2103608A (en) 1983-02-23
SU1358786A3 (ru) 1987-12-07
SE453295B (sv) 1988-01-25
IL66316A (en) 1986-04-29
FI71940C (fi) 1987-03-09
HU186951B (en) 1985-10-28
DK156222C (da) 1989-12-04
AT384614B (de) 1987-12-10
IT8222353A0 (it) 1982-07-12
NZ201194A (en) 1985-02-28
LU84262A1 (fr) 1983-02-07
GB2103608B (en) 1985-01-30
FI71940B (fi) 1986-11-28
KR840000569A (ko) 1984-02-25
PT75240A (en) 1982-08-01
FR2509734A1 (fr) 1983-01-21
IL66316A0 (en) 1982-11-30

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