ES8405403A1 - Procedimiento para la obtencion de 1,4-dihidropiridinas - Google Patents

Procedimiento para la obtencion de 1,4-dihidropiridinas

Info

Publication number
ES8405403A1
ES8405403A1 ES525842A ES525842A ES8405403A1 ES 8405403 A1 ES8405403 A1 ES 8405403A1 ES 525842 A ES525842 A ES 525842A ES 525842 A ES525842 A ES 525842A ES 8405403 A1 ES8405403 A1 ES 8405403A1
Authority
ES
Spain
Prior art keywords
dihydropyridines
condensed
preparation
application
pharmaceutical products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525842A
Other languages
English (en)
Other versions
ES525842A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES525842A0 publication Critical patent/ES525842A0/es
Publication of ES8405403A1 publication Critical patent/ES8405403A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTOS PARA LA OBTENCION DE 1,4-DIHIDROPIRIDINAS. CONSISTE EN: A) CICLIZAR LAS 1,4-DIHIDROPIRIDINAS DE FORMULA (II); B) HACER REACCIONAR ILIDEN-B-CETOESTERES DE FORMULA (III) CON COMPUESTOS DE ENAMINO DE FORMULA (IV); C) HACER REACCIONAR ILIDEN-B-CETOESTERES DE FORMULA (III) CON AMINAS DE FORMULA (V) Y COMPUESTOS CETO DE FORMULA (VI), B Y C SE REALIZAN EN PRESENCIA DE DISOLVENTES ORGANICOS INERTES Y A TEMPERATURAS ENTRE 20JC Y 150JC, PARA OBTENER 1,4-DIHIDROPIRIDINAS DE FORMULA (I), DONDE A SIGNIFICA ARILO, TIENILO, FURILO Y OTROS; Y SIGNIFICA UNO O DOS SUSTITUYENTES IGUALES O DIFERENTESDEL GRUPO ALQUILO, ALQUENILO Y OTROS. X ES UNA CADENA ALQUILO, RECTA O RAMIFICADA CON C 1 A 20; Z ES GRUPO -COOR, UN GRUPO -SO2-R Y OTROS; R, R Y R SON HIDROGENO, RESTOS ALQUILO Y OTROS; R ES UN HIDROCARBURO DE CADENA RECTA, RAMIFICADA O CICLICA; R ES UN RESTO HIDROCARBURO ALIFATICO; Y R ES UN RESTO ALQUILO, ARILO O ARALQUILO.TIENE APLICACIONES FARMACOLOGICAS POR SU INFLUENCIA EN LA CIRCULACION SANGUINEA.
ES525842A 1982-09-23 1983-09-22 Procedimiento para la obtencion de 1,4-dihidropiridinas Expired ES8405403A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823235221 DE3235221A1 (de) 1982-09-23 1982-09-23 Ringverbrueckte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES525842A0 ES525842A0 (es) 1984-06-01
ES8405403A1 true ES8405403A1 (es) 1984-06-01

Family

ID=6173954

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525842A Expired ES8405403A1 (es) 1982-09-23 1983-09-22 Procedimiento para la obtencion de 1,4-dihidropiridinas

Country Status (6)

Country Link
US (1) US4558055A (es)
EP (1) EP0104550A3 (es)
JP (1) JPS5978191A (es)
CA (1) CA1249586A (es)
DE (1) DE3235221A1 (es)
ES (1) ES8405403A1 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4300094A (en) * 1978-04-27 1981-11-10 Micro Sensors, Inc. Finish measuring method and apparatus
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
US4478834A (en) * 1983-02-11 1984-10-23 Usv Pharmaceutical Corporation Dihydropyridines and their use in the treatment of asthma

Also Published As

Publication number Publication date
EP0104550A3 (de) 1986-11-26
CA1249586A (en) 1989-01-31
EP0104550A2 (de) 1984-04-04
US4558055A (en) 1985-12-10
DE3235221A1 (de) 1984-03-29
ES525842A0 (es) 1984-06-01
JPS5978191A (ja) 1984-05-04

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