ES8407478A1 - Un procedimiento para la preparacion de nuevos derivados de tetrahidroquinolina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de tetrahidroquinolina.Info
- Publication number
- ES8407478A1 ES8407478A1 ES519850A ES519850A ES8407478A1 ES 8407478 A1 ES8407478 A1 ES 8407478A1 ES 519850 A ES519850 A ES 519850A ES 519850 A ES519850 A ES 519850A ES 8407478 A1 ES8407478 A1 ES 8407478A1
- Authority
- ES
- Spain
- Prior art keywords
- acyl
- amino
- tetrahydroquinoline compounds
- compounds
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000543 intermediate Substances 0.000 abstract 2
- 150000003530 tetrahydroquinolines Chemical class 0.000 abstract 2
- 230000002425 cardiocirculatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TETRAHIDROQUINOLINA, DE SUS FORMAS INACTIVAS Y OPTICAMENTE ACTIVAS Y DE SUS SALES DE ADICION DE ACIDO DE FORMULA (I), EN LA QUE R2-R7 PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA CON HIDROGENO, EN UN DISOLVENTE ORGANICO, EN PRESENCIA DE UN CATALIZADOR TAL COMO PT, PD, RH O NI RANEY, A UNA TEMPERATURA ENTRE LA AMBIENTE Y 150JC Y A UNA PRESION ENTRE4 Y 150 BARES.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO CARDIOTONICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8123213A IT1226045B (it) | 1981-07-29 | 1981-07-29 | Derivati tetraidrochinolici |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8407478A1 true ES8407478A1 (es) | 1984-10-01 |
| ES519850A0 ES519850A0 (es) | 1984-10-01 |
Family
ID=11204942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515712A Granted ES515712A0 (es) | 1981-07-29 | 1982-07-28 | "un procedimiento para la preparacion de nuevos derivados de tetrahidroquinolina". |
| ES519850A Granted ES519850A0 (es) | 1981-07-29 | 1983-02-16 | Un procedimiento para la preparacion de nuevos derivados de tetrahidroquinolina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515712A Granted ES515712A0 (es) | 1981-07-29 | 1982-07-28 | "un procedimiento para la preparacion de nuevos derivados de tetrahidroquinolina". |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4507307A (es) |
| EP (1) | EP0072070B1 (es) |
| JP (1) | JPS5849367A (es) |
| AT (1) | ATE25845T1 (es) |
| AU (1) | AU560656B2 (es) |
| CA (1) | CA1195331A (es) |
| DE (1) | DE3275645D1 (es) |
| DK (1) | DK337082A (es) |
| ES (2) | ES515712A0 (es) |
| GR (1) | GR77230B (es) |
| IE (1) | IE53401B1 (es) |
| IT (1) | IT1226045B (es) |
| PT (1) | PT75339B (es) |
| ZA (1) | ZA825427B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4801605A (en) * | 1986-08-29 | 1989-01-31 | Ciba-Geigy Corporation | 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans |
| US4992465A (en) * | 1988-09-27 | 1991-02-12 | Ciba-Geigy Corporation | 3-amino-dihydro-(1)-benzopyrans |
| US6180632B1 (en) | 1997-05-28 | 2001-01-30 | Aventis Pharmaceuticals Products Inc. | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2554737A (en) * | 1949-07-22 | 1951-05-29 | Geigy Ag J R | Basically substituted tetrahydroquinoline derivatives |
| US2942024A (en) * | 1957-09-16 | 1960-06-21 | Du Pont | Resolution of lysine |
| GB1111617A (en) * | 1964-07-14 | 1968-05-01 | Glaxo Lab Ltd | Amides of optically active carboxylic acids and (í‚)-2-dehydroemetine or (í¬)-2-dehydroemetine |
| US3452026A (en) * | 1966-03-15 | 1969-06-24 | Bristol Myers Co | Substituted 1,2,3,4-tetrahydroquinolines |
| US3389140A (en) * | 1966-05-16 | 1968-06-18 | Bristol Myers Co | 1-beta-arylaminoethyl-2-methyl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinolines |
| US3389141A (en) * | 1966-05-16 | 1968-06-18 | Bristol Myers Co | 1-beta-aryloxyethyltetrahydro-isoquinolines |
| NO133758C (es) * | 1970-04-04 | 1976-06-23 | Takeda Chemical Industries Ltd | |
| NL188407C (nl) * | 1977-10-18 | 1992-06-16 | Kessels Gerard | Werkwijze voor de bereiding van d(-)-alfa-fenylglycine. |
-
1981
- 1981-07-29 IT IT8123213A patent/IT1226045B/it active
-
1982
- 1982-07-26 IE IE1794/82A patent/IE53401B1/en unknown
- 1982-07-27 EP EP82200959A patent/EP0072070B1/en not_active Expired
- 1982-07-27 DE DE8282200959T patent/DE3275645D1/de not_active Expired
- 1982-07-27 AT AT82200959T patent/ATE25845T1/de not_active IP Right Cessation
- 1982-07-27 CA CA000408115A patent/CA1195331A/en not_active Expired
- 1982-07-28 GR GR68894A patent/GR77230B/el unknown
- 1982-07-28 AU AU86481/82A patent/AU560656B2/en not_active Ceased
- 1982-07-28 ES ES515712A patent/ES515712A0/es active Granted
- 1982-07-28 PT PT75339A patent/PT75339B/pt unknown
- 1982-07-28 DK DK337082A patent/DK337082A/da not_active Application Discontinuation
- 1982-07-28 ZA ZA825427A patent/ZA825427B/xx unknown
- 1982-07-28 US US06/402,551 patent/US4507307A/en not_active Expired - Fee Related
- 1982-07-29 JP JP57131321A patent/JPS5849367A/ja active Pending
-
1983
- 1983-02-16 ES ES519850A patent/ES519850A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU560656B2 (en) | 1987-04-16 |
| IT8123213A0 (it) | 1981-07-29 |
| PT75339A (en) | 1982-08-01 |
| GR77230B (es) | 1984-09-11 |
| ATE25845T1 (de) | 1987-03-15 |
| EP0072070A2 (en) | 1983-02-16 |
| IE821794L (en) | 1983-01-29 |
| IE53401B1 (en) | 1988-11-09 |
| ZA825427B (en) | 1983-08-31 |
| CA1195331A (en) | 1985-10-15 |
| EP0072070A3 (en) | 1983-05-11 |
| JPS5849367A (ja) | 1983-03-23 |
| ES8403458A1 (es) | 1984-04-01 |
| DK337082A (da) | 1983-01-30 |
| PT75339B (en) | 1985-01-04 |
| US4507307A (en) | 1985-03-26 |
| EP0072070B1 (en) | 1987-03-11 |
| DE3275645D1 (de) | 1987-04-16 |
| AU8648182A (en) | 1983-02-03 |
| ES515712A0 (es) | 1984-04-01 |
| IT1226045B (it) | 1990-12-10 |
| ES519850A0 (es) | 1984-10-01 |
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