ES8501400A1 - Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo-(4, 3-b) piridazinas - Google Patents

Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo-(4, 3-b) piridazinas

Info

Publication number
ES8501400A1
ES8501400A1 ES530640A ES530640A ES8501400A1 ES 8501400 A1 ES8501400 A1 ES 8501400A1 ES 530640 A ES530640 A ES 530640A ES 530640 A ES530640 A ES 530640A ES 8501400 A1 ES8501400 A1 ES 8501400A1
Authority
ES
Spain
Prior art keywords
pyridazines
triazolo
aryl
amino
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530640A
Other languages
English (en)
Other versions
ES530640A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES530640A0 publication Critical patent/ES530640A0/es
Publication of ES8501400A1 publication Critical patent/ES8501400A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 3-AMINO-6-ARIL-1,2,4-TRIAZOLO 4,3-B PIRIDAZINAS.CONSISTE EN CICLIZAR UN COMPUESTO DE FORMULA (V) EN DONDE AR, R Y R TIENEN LOS SIGNIFICADOS INDICADOS PARA LA FORMULA I Y Z REPRESENTA O, S O NH, MEDIANTE CALENTAMIENTO CON ADICION DE UN AGENTE CONDENSANTE, PARA DAR UN COMPUESTO DE FORMULA (I) EN DONDE R Y R REPRESENTAN HIDROGENO, GRUPOS ALCOHILO CON C 1 A 6, FENILO O CLORO, Y AR REPRESENTA RADICALES AROMATICOS TALES COMO FENILO, FENOXIFENILO, FENILSULFINILFENILO, 1- O 2-NAFTILO. EL COMPUESTO ASI OBTENIDO SE TRANSFORMA, CON UN ACIDO FISIOLOGICAMENTE TOLERABLE, EN LA SAL.
ES530640A 1982-05-08 1984-03-15 Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo-(4, 3-b) piridazinas Expired ES8501400A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823217325 DE3217325A1 (de) 1982-05-08 1982-05-08 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
ES530640A0 ES530640A0 (es) 1984-11-16
ES8501400A1 true ES8501400A1 (es) 1984-11-16

Family

ID=6163075

Family Applications (4)

Application Number Title Priority Date Filing Date
ES522144A Expired ES8405800A1 (es) 1982-05-08 1983-05-06 Procedimiento para la preparacion de 3-amino-6-aril-1,2,4-triazolo(4,3-b)piridazinas.
ES530638A Expired ES8501398A1 (es) 1982-05-08 1984-03-15 Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinas
ES530640A Expired ES8501400A1 (es) 1982-05-08 1984-03-15 Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo-(4, 3-b) piridazinas
ES530639A Granted ES530639A0 (es) 1982-05-08 1984-03-15 Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES522144A Expired ES8405800A1 (es) 1982-05-08 1983-05-06 Procedimiento para la preparacion de 3-amino-6-aril-1,2,4-triazolo(4,3-b)piridazinas.
ES530638A Expired ES8501398A1 (es) 1982-05-08 1984-03-15 Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES530639A Granted ES530639A0 (es) 1982-05-08 1984-03-15 Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinas

Country Status (19)

Country Link
EP (1) EP0094038B1 (es)
JP (1) JPS58203992A (es)
KR (1) KR840004753A (es)
AT (1) ATE24728T1 (es)
AU (1) AU1434383A (es)
CA (1) CA1201122A (es)
DE (2) DE3217325A1 (es)
DK (1) DK204783A (es)
ES (4) ES8405800A1 (es)
FI (1) FI831548L (es)
GR (1) GR79281B (es)
HU (1) HU189277B (es)
IE (1) IE55096B1 (es)
IL (1) IL68611A0 (es)
MA (1) MA19791A1 (es)
NO (1) NO831614L (es)
NZ (1) NZ204153A (es)
PT (1) PT76654B (es)
ZA (1) ZA833239B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3311753A1 (de) * 1983-03-31 1984-10-04 Hoechst Ag, 6230 Frankfurt Substituierte 6-aryl-1,2,4-triazolo(4,3-b)pyridazine - ihre herstellung und verwendung -
FR2562071B1 (fr) * 1984-03-30 1986-12-19 Sanofi Sa Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
JP2008518955A (ja) 2004-11-02 2008-06-05 ノースウェスタン ユニバーシティ ピリダジン化合物および方法
CA2589106C (en) 2004-11-02 2015-07-21 Northwestern University Pyridazine compounds, compositions and methods and their use in treating inflammatory diseases
AU2007243280A1 (en) 2006-04-28 2007-11-08 Northwestern University Formulations containing pyridazine compounds for treating neuroinflammatory diseases
US8158627B2 (en) 2006-04-28 2012-04-17 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
AU2008223066A1 (en) * 2007-03-02 2008-09-12 Northwestern University Compositions comprising derivatives of 3 -phenylpyridazine for treating seizure-related disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128809C (es) * 1966-06-18
US3708484A (en) * 1970-10-16 1973-01-02 Sandoz Ag Amino and substituted amino-s-triazolo-(4,3-b)-pyridazines
DE2113438A1 (de) * 1971-03-19 1972-09-21 Boehringer Mannheim Gmbh Nitrofuryl-triazolo[4,3-b]pyridazinderivate
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
US4260756A (en) * 1979-11-15 1981-04-07 American Cyanamid Company 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines

Also Published As

Publication number Publication date
ES522144A0 (es) 1984-06-16
EP0094038A1 (de) 1983-11-16
PT76654B (de) 1986-01-28
DK204783D0 (da) 1983-05-06
DE3217325A1 (de) 1983-11-10
AU1434383A (en) 1983-11-10
ES8501399A1 (es) 1984-11-16
FI831548A7 (fi) 1983-11-09
HU189277B (en) 1986-06-30
ES8405800A1 (es) 1984-06-16
ES530638A0 (es) 1984-11-16
CA1201122A (en) 1986-02-25
FI831548L (fi) 1983-11-09
ES8501398A1 (es) 1984-11-16
FI831548A0 (fi) 1983-05-05
IE55096B1 (en) 1990-05-23
DK204783A (da) 1983-11-09
NO831614L (no) 1983-11-09
JPS58203992A (ja) 1983-11-28
ES530639A0 (es) 1984-11-16
GR79281B (es) 1984-10-22
KR840004753A (ko) 1984-10-24
ES530640A0 (es) 1984-11-16
DE3368931D1 (en) 1987-02-12
ATE24728T1 (de) 1987-01-15
EP0094038B1 (de) 1987-01-07
IE831043L (en) 1983-11-08
PT76654A (de) 1983-06-01
NZ204153A (en) 1985-04-30
MA19791A1 (fr) 1983-12-31
IL68611A0 (en) 1983-09-30
ZA833239B (en) 1984-01-25

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