ES8501438A1 - Un procedimiento para preparar un derivado del complejo activador de plasminogeno humano-estreptoquinasa. - Google Patents

Un procedimiento para preparar un derivado del complejo activador de plasminogeno humano-estreptoquinasa.

Info

Publication number
ES8501438A1
ES8501438A1 ES521278A ES521278A ES8501438A1 ES 8501438 A1 ES8501438 A1 ES 8501438A1 ES 521278 A ES521278 A ES 521278A ES 521278 A ES521278 A ES 521278A ES 8501438 A1 ES8501438 A1 ES 8501438A1
Authority
ES
Spain
Prior art keywords
preparing
pharmaceutical compositions
compositions containing
5sec
enzyme derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521278A
Other languages
English (en)
Other versions
ES521278A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES521278A0 publication Critical patent/ES521278A0/es
Publication of ES8501438A1 publication Critical patent/ES8501438A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN DERIVADO DEL COMPLEJO ACTIVADOR DE PLASMINOGENO HUMANO-ESTREPTOQUINASA, EN EL QUE EL SITIO CATALITICO ACTIVO ESENCIAL PARA LA ACTIVIDAD FIBRINOLITICA ESTA SUSTITUIDO OPCIONALMENTE EN EL ANILLO AROMATICO CON UN RADICAL DADOR DE ELECTRONES.CONSISTE EN SOMETER A REACCION EL COMPLEJO, ACTIVADOR DE PLASMINOGENO ESTREPTOQUINASA CON UN AGENTE BLOQUEANTE, DE FORMULA: AB, EN LA QUE A ES UN GRUPO LOCALIZANTE QUE LOCALIZA EL AGENTE EN EL SITIO CATALITICO, Y B ES UN GRUPO 2- O 4-AMINOBENZOILO OPCIONALMENTE SUSTITUIDO EN EL ANILLO AROMATICO CON UN RADICAL DADOR DE ELECTRONES.DE APLICACION EN EL TRATAMIENTO DE LA TROMBOSIS VENOSA.
ES521278A 1982-04-07 1983-04-06 Un procedimiento para preparar un derivado del complejo activador de plasminogeno humano-estreptoquinasa. Expired ES8501438A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8210262 1982-04-07

Publications (2)

Publication Number Publication Date
ES521278A0 ES521278A0 (es) 1984-12-01
ES8501438A1 true ES8501438A1 (es) 1984-12-01

Family

ID=10529573

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521278A Expired ES8501438A1 (es) 1982-04-07 1983-04-06 Un procedimiento para preparar un derivado del complejo activador de plasminogeno humano-estreptoquinasa.

Country Status (8)

Country Link
US (1) US4507283A (es)
EP (1) EP0091240B1 (es)
JP (1) JPS58185526A (es)
AU (1) AU1315283A (es)
CA (1) CA1192514A (es)
DE (1) DE3361610D1 (es)
ES (1) ES8501438A1 (es)
ZA (1) ZA832396B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8319538D0 (en) * 1983-07-20 1983-08-24 Beecham Group Plc Compounds
JPS6089577A (ja) * 1983-10-19 1985-05-20 Denki Kagaku Kogyo Kk 透明ａｂｓ樹脂
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
JPH0635499B2 (ja) * 1984-02-09 1994-05-11 電気化学工業株式会社 Ａｂｓ系樹脂メッキ製品
GB8430253D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
EP0297882B1 (en) * 1987-07-01 1993-08-25 Beecham Group Plc Hybrid plasminogen activators
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
US8252228B1 (en) * 2008-10-13 2012-08-28 Abbott Cardiovascular Systems Inc. Methods for sterilizing carriers for treatment of a kidney
US9257481B2 (en) 2012-11-26 2016-02-09 Epistar Corporation LED arrray including light-guiding structure

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
DE3065190D1 (en) * 1979-11-05 1983-11-10 Beecham Group Plc Enzyme derivatives, and their preparation

Also Published As

Publication number Publication date
US4507283A (en) 1985-03-26
EP0091240A3 (en) 1984-04-18
EP0091240A2 (en) 1983-10-12
CA1192514A (en) 1985-08-27
EP0091240B1 (en) 1985-12-27
ES521278A0 (es) 1984-12-01
JPS58185526A (ja) 1983-10-29
ZA832396B (en) 1984-01-25
AU1315283A (en) 1983-10-13
DE3361610D1 (en) 1986-02-06

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